Aquaporins, a highly conserved group of membrane proteins, are involved in the bidirectional transfer of water and small solutes across cell membranes taking part in many biological functions all over the human body. In view of the wide range of cancer malignancies in which aquaporin-5 (AQP5) has been detected, an increasing interest in its implication in carcinogenesis has emerged. Recent publications suggest that this isoform may enhance cancer cell proliferation, migration and survival in a variety of malignancies, with strong evidences pointing to AQP5 as a promising drug target and as a novel biomarker for cancer aggressiveness with high translational potential for therapeutics and diagnostics. This review addresses the structural and functional features of AQP5, detailing its tissue distribution and functions in human body, its expression pattern in a variety of tumors, and highlighting the underlying mechanisms involved in carcinogenesis. Finally, the actual progress of AQP5 research, implications in cancer biology and potential for cancer detection and prognosis are discussed.
When attending and participating in Higher Education, students face a multitude of personal, social, and work-related challenges, which may increase the risk of developing psychopathological symptomatology. To date, there is no instrument that grasps the non-technical skills that may help prepare students to respond to these challenges. This paper presents the development and psychometric properties of the Soft Skills Inventory (SSI). The inventory was developed based on theoretical and empirical findings on the skills associated with academic and professional success, and on students’ perception. The SSI was tested with 2030 Portuguese students (of which 77.1% were female) using a two-stage approach: item calibration and model generation (n = 1033), followed by model validation (n = 997). Item calibration analyses led to retaining 49 items that were organized into six-factors: self-determination, resilience, empathy, assertiveness, social support, and teamwork. This measurement model was further validated and proved to be an invariant, and thus credible, tool to compare male and female students on those relevant skills. All measures attained good internal consistency, with alphas ranging from .76 to .88. Female students scored significantly higher than males on self-determination, empathy, social support and teamwork. On the other hand, male students scored significantly higher on resilience. No significant differences were found between men and women for assertiveness. Psychometric analysis showed that the SSI is a reliable and valid instrument to evaluate students intra and interpersonal skills. The SSI may help identify gaps in soft skills and guide targeted interventions to support a more positive student experience in Higher Education.
Context-based learning (CBL) approaches have been recommended and expanded in science education to make science more relevant to students by connecting science content with students' daily life. Subsequently, in order to implement CBL at school, a group of scenarios has been produced by several stakeholders. However, there is a lack of resources to measure effectively what makes a good scenario. Thus, this study aims to develop and validate a scenario evaluation instrument to examine students' perspectives on science career-related scenarios through the lens of relevance and interest. For this purpose, 25 science career-related scenarios and a measurement tool, Scenario Evaluation with Relevance and Interest (SERI), were developed by a team of researchers for the EU funded MultiCO project. Then, lower secondary school students from three different countries, Estonia, Finland, and the UK, were asked to respond to the newly developed instrument after reading the scenarios, and their responses were analyzed by factor analyses and multivariate analysis of variance. According to the result, this instrument has good construct validity and reliability. However, it indicates one issue of discriminant validity between two factors, individual dimension and societal dimension. Also, significant gender differences were found in the Estonian sample regarding students' perspectives on the scenarios. Possible interpretations of the results and implications of the suggested measurement tool are discussed.
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