Hormone replacement therapy (HRT) reduces expression of cell adhesion molecules in healthy postmenopausal women

Effect of hormone replacement therapy on inflammation‐sensitive proteins in post‐menopausal women with Type 2 diabetes

“…Post hoc calculation shows that our study had sufficient statistical power to detect a change in plasma ICAM‐1 levels of approximately 58 µg/l at 80% power and a 5% confidence level. This change is less than the 75 µg/l decrease in plasma ICAM‐1 levels during HRT in 52 healthy women reported previously [ 30 ]. Whether the composition of the HRT and particularly the type of progestin used, or the presence of diabetes contributed to the absence of a clear decrease in plasma levels of cell adhesion molecules in the present study is unclear.…”

“…Short‐term HRT (12 weeks) with oestradiol alone or oestradiol plus trimegestone decreases plasma levels of VCAM‐1 and ICAM‐1, while levels remain unchanged during therapy with oestradiol plus dydrogesterone in healthy post‐menopausal women [29 ]. In addition, a recent study has reported a decrease in plasma ICAM‐1 levels in healthy post‐menopausal women during 6 months oral HRT with oestradiol plus norethisterone acetate [ 30 ]. In the present study, HRT did not influence plasma ICAM‐1 levels and its effect on plasma VCAM‐1 levels was equivocal.…”