Hormone replacement therapy, cardiovascular and cerebrovascular disease

Teede, Helena

doi:10.1016/s1521-690x(02)00083-0

Cited by 16 publications

(20 citation statements)

References 58 publications

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“…Most osteoprotective medicines have some adverse effects. For instance, increased risk of cancer (Krieger et al ., ) and cardiovascular diseases (Teede, ) were reported to be associated with hormone replacement therapy. It has also been reported that anti‐resorptive bisphosphonate might result in upper gastrointestinal tract complications (Marshall, ) as well as long‐range effects on the skeleton, especially in regard to bone turnover and strength (Arum, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells

Liu

Yang

2014

J Tissue Eng Regen Med

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Human amniotic fluid-derived stem cells (hAFSCs) are a novel cell source for generating osteogenic cells to treat bone diseases. Effective induction of osteogenic differentiation from hAFSCs is critical to fulfil their therapeutic potential. In this study, naringin, the main active compound of Rhizoma drynariae (a Chinese herbal medicine), was used to stimulate the proliferation and osteogenic differentiation of hAFSCs. The results showed that naringin enhanced the proliferation and alkaline phosphatase activity (ALP) of hAFSCs in a dose-dependent manner in the range 1-100 µg/ml, while an inhibition effect was observed at 200 µg/ml. Consistently, the calcium content also increased with naringin concentration up to 100 µg/ml. The enhanced osteogenic differentiation of hAFSCs by naringin was further confirmed by the dose-dependent upregulation of marker genes, including osteopontin (OPN) and Collagen I from RT-PCR analysis. The increased osteoprotegerin (OPG) expression and minimal expression of receptor activator of nuclear factor-κB ligand (RANKL) suggested that naringin also inhibited osteoclastogenesis of hAFSCs. In addition, the gene expressions of bone morphogenetic protein 4 (BMP4), runt-related transcription factor 2 (RUNX2), β-catenin and Cyclin D1 also increased significantly, indicating that naringin promotes the osteogenesis of hAFSCs via the BMP and Wnt-β-catenin signalling pathways. These results suggested that naringin can be used to upregulate the osteogenic differentiation of hAFSCs, which could provide an attractive and promising treatment for bone disorders. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells

Liu

Yang

2014

J Tissue Eng Regen Med

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“…For example, estrogen replacement therapy is associated with increased risk of cancer [18] and cardiovascular diseases [19]. Anti-resorptive bisphosphonate therapy may lead to complications on upper gastrointestinal tract [20] and long-term effects on the skeleton, particular with respect to bone turnover and strength are unclear [21].…”

Section: Discussionmentioning

confidence: 99%

Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats

Siu

Lau

et al. 2010

Chin Med

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BackgroundFructus Ligustri Lucidi (FLL) is a commonly used herb for treating bone disorders in Chinese medicine. The present study investigates the anti-osteoporotic activity of FLL aqueous extract in the model of postmenopausal bone loss in aged ovariectomized (OVX) female rats.MethodsAfter eight weeks of treatment of FLL or water, the lumbar spine was scanned by peripheral quantitative computed tomography (pQCT). Effects of FLL water extract on osteogenic and adipogenic differentiations in rat mesenchymal stem cells (MSCs) were assessed by biochemical methods and staining.ResultsFLL aqueous extract significantly inhibited bone mineral density (BMD) loss in total, trabecular and cortical bones without affecting body weight and uterus wet weight. FLL extract significantly promoted osteogenesis and suppressed adipogenesis in MSCs as indicated by the elevated alkaline phosphatase activity, calcium deposition levels and decreased adipocyte number in a dose-dependent manner without cytotoxic effects. Real-time PCR analysis revealed significant increase of osteoprotegerin (OPG)-to-receptor activator for nuclear factor-κB ligand (RANKL) mRNA, indicating a decrease in osteoclastogenesis.ConclusionThe present study demonstrates the osteoprotective effects of FLL aqueous extract on aged OVX rats, stimulation of osteogenesis, inhibition of adipogenesis and osteoclastogenesis in MSCs.

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“….) [3][4][5][6][7][8][9][10][11][12]. The Women's Health Initiative (WHI) safety committee decided to interrupt one arm of a study after a mean of 5.2 years follow-up, because women on the combined estrogen-progestin therapy had an increased risk for cardiovascular events and breast cancer, though with a lesser risk of osteoporotic fractures and colon cancer [13].…”

Section: Rationale For Red Clover Products For Hormone Replacement Thmentioning

confidence: 99%

Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy?

Beck¹,

Rohr²,

Jungbauer³

2005

The Journal of Steroid Biochemistry and Molecular Biology

213

131

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Hormone replacement therapy, cardiovascular and cerebrovascular disease

Cited by 16 publications

References 58 publications

Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells

Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells

Osteoprotective effects of Fructus Ligustri Lucidi aqueous extract in aged ovariectomized rats

Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy?

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