Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass

Bahl, Aileen; Pöllänen, Eija; Ismail, Khadeeja; Sipilä, Sarianna; Mikkola, Tuija M.; Berglund, Eva; Lindqvist, Carl Mårten; Syvänen, Ann‐Christine; Rantanen, Taina; Kaprio, Jaakko; Kovanen, Vuokko; Ollikainen, Miina

doi:10.1017/thg.2015.82

Cited by 17 publications

(19 citation statements)

References 64 publications

(88 reference statements)

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“…The circulating miRs showing differential expression due to use of HRT were associated with apoptosis, inflammation and body metabolic pathways (Kangas et al, 2014;Kangas, Morsiani et al, 2017). These results are in line with our previous results indicating that the use of HRT affects muscle signaling at transcriptome (Ronkainen et al, 2010) and proteome (Laakkonen et al, 2017) levels, as well as white blood cell signaling at methylome and transcriptome levels (Bahl et al, 2015).…”

Section: Estrogen and Sarcopenia: A Co-twin Study With Hrt Discordantsupporting

confidence: 90%

The Older Finnish Twin Cohort — 45 Years of Follow-up

et al. 2019

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The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in 1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments was done in three parts, with a questionnaire study of twins born during 1945–1957 in 2011–2012, while older twins were interviewed and screened for dementia in two time periods, between 1999 and 2007 for twins born before 1938 and between 2013 and 2017 for twins born in 1938–1944. The content of these wave 4 assessments is described and some initial results are described. In addition, we have invited twin-pairs, based on response to the cohortwide surveys, to participate in detailed in-person studies; these are described briefly together with key results. We also review other projects based on the older FTC and provide information on the biobanking of biosamples and related phenotypes.

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Section: Estrogen and Sarcopenia: A Co-twin Study With Hrt Discordantsupporting

confidence: 90%

The Older Finnish Twin Cohort — 45 Years of Follow-up

et al. 2019

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“…Even though no direct effect of E 2 has been stated in the mentioned studies, it has been well demonstrated that estrogen has a role as a neuro-, osteo- and vascular protector 28 29 30 31 . Our earlier studies have also shown beneficial effects of postmenopausal HRT on body composition measures, including fat, muscle and bone properties 32 33 34 35 36 . The connection between lipoproteins, vascular inflammation and exosomes has also been recognized by others 37 .…”

Section: Discussionmentioning

confidence: 77%

Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy

Kangas

Törmäkangas

Fey

et al. 2017

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Exosomes participate in intercellular messaging by transporting bioactive lipid-, protein- and RNA-molecules and -complexes. The contents of the exosomes reflect the physiological status of an individual making exosomes promising targets for biomarker analyses. In the present study we extracted exosome microRNAs (exomiRs) from serum samples of premenopausal women (n = 8) and monozygotic postmenopausal twins (n = 10 female pairs), discordant for the use of estrogenic hormone replacement therapy (HRT), in order to see whether the age or/and the use of HRT associates with exomiR content. A total of 241 exomiRs were detected by next generation sequencing, 10 showing age, 14 HRT and 10 age +HRT -related differences. When comparing the groups, differentially expressed miRs were predicted to affect cell proliferation processes showing inactivation with younger age and HRT usage. MiR-106-5p, -148a-3p, -27-3p, -126-5p, -28-3p and -30a-5p were significantly associated with serum 17β-estradiol. MiRs formed two hierarchical clusters being indicative of positive or negative health outcomes involving associations with body composition, serum 17β-estradiol, fat-, glucose- and inflammatory markers. Circulating exomiR clusters, obtained by NGS, could be used as indicators of metabolic and inflammatory status affected by hormonal changes at menopause. Furthermore, the individual effects of HRT-usage could be evaluated based on the serum exomiR signature.

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“…HRT was found to affect the body composition in healthy elders, but at least part of the known beneficial HRT effects on body composition and bone mass may be regulated by DNA methylation associated alterations in gene expression in circulating white blood cells16. The effect of HRT on the body composition in patients with TS remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Body composition and bone mineral status in patients with Turner syndrome

Shi

Liu

et al. 2016

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Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body composition and decreased bone mineral status parameters in patients with TS. This study included 24 girls with TS, in which 13 girls exhibited X0 karyotype and 11 had mosaicism. Quantitative ultrasound (QUS) assessed the bone mineral status of the calcaneus, including bone mineral density (BMD), amplitude-dependent speed of sound (AD-SOS), broadband ultrasound attenuation (BUA) and InBody 770 assessed body composition. Pearson’s test was performed to correlate measured parameters with patient age. The body composition and bone mineral status parameters were not significantly influenced by patient karyotype. There was a correlation between patient age and AD-SOS (r = −0.61, P = 0.002) and BUA (r = 0.50, P = 0.013) but not BMD (r = −0.19, P = 0.379). In conclusion, there was no effect of karyotype on body composition or body mineral status. Bone mineral status, as evidenced by changes in AD-SOS and BUA, alters with age regardless of karyotype. The developmental trajectory demonstrated in the current study warrants further validation in a longitudinal study.

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Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass

Cited by 17 publications

References 64 publications

The Older Finnish Twin Cohort — 45 Years of Follow-up

The Older Finnish Twin Cohort — 45 Years of Follow-up

Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy

Body composition and bone mineral status in patients with Turner syndrome

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