Hormone Receptors and Breast Cancer: Correlations with Clinical and Histologic Features

Montesco, Maria Cristina; Pluchinotta, Alfonso M.; Piffanelli, A; Pelizzola, D; Giovannini, Gloria; Pagnini, Carla Arslan

doi:10.1177/030089168407000510

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…Several studies have reported similar association [ 15 , 18 , 27 ]. Finally, our results do not confirm earlier studies in which the expression of ER was associated with the nature of the presence of lymphocytes in the vicinity of the tumour [ 57 , 58 ]. We chose to examine the nature of the presence of tumour lymphocytes as one of the tumour characteristics that we examined in this study, since such a characteristic could provide an insight into the immunological status of the tumour.…”

Section: Discussioncontrasting

confidence: 99%

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Saleh¹,

Abdeen²

2007

Journal of Carcinogenesis

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BackgroundBreast cancer accounts for 30.3% of all cancer types in Kuwaiti women. Death occurs in approximately 43% of these patients. Our goal was to conduct a comprehensive analysis of the pathobiological characteristics of the tumours in an attempt to determine any particular trend that could be present.MethodsOne hundred and sixty-six cases were included in this study. All the pathology reports and paraffin blocks pertaining to these cases were collected. Four micrometer sections were taken from each block, and immunostaining against Her-2, ER, and PgR was performed. Both the proportion and intensity of immunostaining were scored according to the Allred's method, and typing of the tumour was done according the WHO criteria regarding tumour classification. Grading of invasive carcinomas was done according to the modified Bloom-Richardson-Elston's method, and tumour stage was determined according to the criteria set by the American Joint Committee on Cancer.ResultsThe mean age of the patients below 55 years was 40, as compared to 68 for those above 55 (p < 0.0001). More than half of the cases were in the right breast, and were surgically treated by total mastectomy with axillary clearance. The majority of the tumours had irregular (stellate) margins, was invasive, and had a surrounding breast tissue of adenosis or fibrocystic type. Their mitotic index was 10–20 or >20 with a marked to moderate nuclear pleomorphism. They were mostly grade II or III, sized 2–5 or > 5 cm, had absent or scanty tumour lymphocytes, and were stage II or III. The in situ tumours were mainly ductal carcinoma (DCIS) of which comedo and cribriform were the major histological subtypes. The major histological subtypes of the invasive tumours were ductal-not otherwise specified, lobular, and tubular/cribriform. In this study, we also found a significant (p < 0.05) association between over expression of Her-2, lack of expression of ER and some of the characteristics mentioned above.ConclusionBreast cancer in Kuwait seems to be more aggressive than what is currently seen in Europe, North America, Australia, and parts of Asia. Further investigations regarding the features observed in this study need to be performed.

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Section: Discussioncontrasting

confidence: 99%

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Saleh¹,

Abdeen²

2007

Journal of Carcinogenesis

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“…Prior analyses of the effect of age and menopausal status on the expression of prognostic or predictive markers in breast carcinomas have been limited in the factors assessed; however, studies have demonstrated that breast carcinomas in younger or premenopausal women are more likely to exhibit biologic and prognostic features that are known to be associated with a high histologic grade, such as an absence of steroid hormone receptors, 31,42 , a high rate of proliferation 43 and abnormalities in p53 protein. 8,24 -26 It has been hypothesized that this adverse pattern of prognostic indicators and the poorer clinical outcome of younger, premenopausal patients were secondary to the greater proportion of higher grade carcinomas found in these women.…”

Section: Discussionmentioning

confidence: 99%

Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre‐ and postmenopausal women

Talley

Grizzle

Waterbor

et al. 2001

Intl Journal of Cancer

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Breast cancers in younger, premenopausal women are more likely to exhibit an adverse prognostic profile (including negative steroid hormone receptors and a high rate of cellular proliferation) and poor outcome than breast cancers in postmenopausal women. It has been hypothesized that this adverse prognostic profile is a result of the higher histologic grade of breast cancers in pre-compared with post-menopausal women. To assess the association of expression of steroid hormone receptors and indicators of proliferation while controlling for histologic grade, we identified 100 infiltrating ductal carcinomas from premenopausal women 45 years of age or younger and 100 from postmenopausal women 65 years of age or older. The carcinomas were selected so that the histologic grades (low versus high) were distributed equally between the 2 groups. Estrogen receptors (ER), progesterone receptors (PR), p27 Kip1 and Ki-67 (to measure rate of proliferation) were assessed by immunohistochemistry and compared between groups. Clinical information and survival data were also analyzed. ER content was lower and proliferation was higher in carcinomas in premenopausal women (p ‫؍‬ 0.048 and p ‫؍‬ 0.005, respectively). By univariate analysis, p27 Kip1 and PR were not different between the groups; however, in multivariate analysis, p27 Kip1 was higher in postmenopausal women, but only in a subgroup with highly proliferative carcinomas. Overall survival was similar in the pre-and postmenopausal women. Furthermore, low p27 Kip1 and African-American ethnicity predicted a poorer overall survival in the premenopausal, but not in the postmenopausal, women in our study. After controlling for histologic grade, a lower expression of ER and a higher proliferative index were detected in breast carcinomas in premenopausal women. Therefore, some prognostic indicators, such as ER and proliferative rate, may be more closely associated with menopausal status than histologic grade. Our data also suggest that some prognostic factors are not equally effective as predictors of survival in pre-and postmenopausal women. Prognosis in women with breast cancer has been reported to differ according to age and menopausal status. Studies examining this issue have varied in design, age categorization and outcome measures. A few large population-based studies and more limited analyses 1-5 have indicated that women under the ages of 30 -40 years have a worse prognosis. Some retrospective studies have attempted to explain the less favorable outcome in younger women and have reported that breast cancers in younger women exhibit more adverse characteristics, including a high clinical stage at diagnosis, high histologic grade, lack of steroid hormone receptors and increased proliferation. 6 -9 Multivariate analyses to assess associations of age and menopausal status with other clinical and pathologic characteristics have not consistently retained either variable as an independent adverse prognosticator, 8 although several multivariate analyses have indicated that young ag...

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“…Γπάρχουν βέβαια και οι ερευνητές εκείνοι, που• υποστηρίζουν ότι δεν υ πάρχει 1 καμμ,ία συσχέτιση μεταξύ του ιστολογικού• τύπου και-των υποδοχέων ' (Terenius, et al, 1974, Miïïis, 1980, Fisher, et al, 1981, Nishimura, et al, 1981, Tulusan, et al, 1982, Montesco, et al, 1984, ή καταλήγουν σε μία σχετική έλλειψη συσχέτισης μεταξύ των δύο παραμέ τρων ÇMcCarty, et al, 1980).…”

Section: ιστολογικός τύπος του όγκου και υποδοχείς οιστρογόνωνunclassified

“…Ελάχιστοι μόνο μελετητές δεν έχουν βρει καμμία συσχέτιση, μεταξύ των δύο παραμέτρων , Howat, et al, 1983, Νέκρωση και υποδοχείς οιστρογόνων Η έκταση της νέκρωσης του όγκου εμφανίζει επίσης μία αντιστρόφως ανάλογη συσχέτιση με τη συγκέντρωση• των υποδοχέων. Όγκοι, στους οποίους δεν ανευρίσκονται νεκρώσεις ή όπου αναγνωρίζονται μόνο περιορισμένες εστίες νέκρωσης, είναι πιο συχνά θετικοί για υποδοχείς οιστρογόνων (Fisher, et al, 1980, Montesco, et al 1984.…”

Section: λεμφοκυτταρική διήθηση του στρώματος και υποδοχείς οιστρογόνωνunclassified

“…Σε μελέτες που έχουν γίνει στην ομάδα των πρσεμμηνοπαυσιακών ασθ'ε-* νών, έχει αναφερθεί μία θετική συσχέτιση του περιεχομένου των υποδοχέων με την ομαλότητα των εμμήνων (Montesco, et al, 1984) . Ακόμη οι υψηλό τερες τιμές υποδοχέων και ως προς την επίπτωση και ως προς τη συγκέντρω ση έχουν βρεθεί κατά την αρχόμενη παραγωγική φάση.…”

Section: υποδοχεις οιστρογονων και κλινικα χαρακτηριστικα του ογκουunclassified

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Ανοσοιστοχημικη Ανιχνευση Υποδοχεων Οιστρογονων Σε Καρκινο Του Μαστου. Συγκριτικη Μελετη

Kaloutsi¹,

Καλούτση²

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Ώαϋολογοανατομικού Εργαστηρίου Ιωαννίνων κ. Σ. Στεφανάκη -Νίκου για τις συμβουλές της και τη συμμετοχή της στην εκτίμηση των ιστολογι κών τύπων των περιπτώσεων. Τέλος ευχαριστώ τους παρασκευαστές Α. Χριστοδούλου, Μ. Αλεξίου και Α. Θέμου για την τεχνική βοήυεια, καϋ•ώς και τη φίλη μου Σ. Βουτνράκη για τη δακτυλογράφηση κοα την επιμέλεια του κειμένου.

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Hormone Receptors and Breast Cancer: Correlations with Clinical and Histologic Features

Cited by 9 publications

References 21 publications

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Pathobiological features of breast tumours in the State of Kuwait: a comprehensive analysis

Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre‐ and postmenopausal women

Ανοσοιστοχημικη Ανιχνευση Υποδοχεων Οιστρογονων Σε Καρκινο Του Μαστου. Συγκριτικη Μελετη

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