Hormone profiles and their relation with menstrual cycles in patients undergoing hemodialysis

Abstract

Objective: To investigate the etiology of menstrual disorders among patients undergoing hemodialysis due to chronic renal failure by assessing menstrual history, serum hormone levels and other biochemical factors. Material and methods: Thirty patients undergoing hemodialysis and 30 healthy women at reproductive age were enrolled in our study. Demographic characteristics, hormonal and biochemical data, sonographically measured endometrial thickness values of the subjects were compared. In addition, the present and the pre-hemodialysis menstrual pattern of the patients undergoing hemodialysis were recorded. The hormonal, hematological and biochemical data of the patients were compared according to their menstrual patterns. Results: No statistical significance was seen between age, BMI, gravida, parity, abortion and curettage among groups (p>0.05). Hemoglobin and hematocrit levels were significantly lower in the hemodialysis group than in the control (p<0.05). Although serum FSH levels were higher and estradiol levels were lower in the hemodialysis group, these differences were not statistically significant (p>0.05). Mean serum LH and prolactin levels were significantly higher in the hemodialysis group compared to the control (p<0.05). No statistically significant difference was noted for endometrial thickness between the groups (p>0.05). Serum LH and prolactin levels were higher and serum FSH, estradiol and TSH levels were lower in patients who developed amenorrhea after hemodialysis treatment when compared to non-amenorrheic subjects. However, these differences were not statistically significant (p>0.05). Discussion: The most important factor in the etiology of menstrual disorders seen in chronic renal failure patients was high serum LH and prolactin levels. Hemodialysis is a successful treatment that extends life expectancy and ameliorates the hypothalamo-pituitary-ovarian axis in chronic renal failure patients.

Modificações corporais vivenciadas por pacientes com doença renal crônica em hemodiálise

“…Estudio identificó que la presencia de la fístula genera sentimientos de conformismo en los pacientes que realizan hemodiálisis, sin embargo, esta provoca cambios en la autoimagen del paciente, disminución en la autoestima, sentimientos negativos y desorganiza las relaciones sociales, al sentirse en inferioridad (23) . Para los pacientes, la necesidad de creación de la fístula es una de las primeras marcas corporales derivadas de la DRC.…”

Electron ionization (EI) mass spectra of some 3,4-disubstituted-1,2,4-oxadiazin-5-ones and -thiones and 3,5-disubstituted 1,2,4-oxadiazin-6-ones

“…antibacterial against some micro-organisms and yeast cultures. 5 Only some low resolution EI data are available for a few 1,2,4-oxadiazin-5-ones 6,7 and two 1,2,4-oxadiazin-5-thiones. 6 No published mass spectrometric data was found for 1,2,4-oxadiazin-6-ones.…”

“…The syntheses of the studied compounds have been published earlier. 5,8 The low resolution EI mass spectra of some 3,4-disubstituted-1,2,4-oxadiazin-5-ones (cf. Figure 1: 11−13) and -5-thiones (cf.…”

“…The title compounds possess a diversity of pharmacological activities, [1][2][3][4][5] e.g. antibacterial against some micro-organisms and yeast cultures.…”

Synthesis, spectral behavior and biological activity of some novel 1,3,4-oxadiazine cyanine dyes

“…On the other side, oxadiazine compounds have been demonstrated to be important heterocyclic scaffold platform with bioactive diversity, which present wide activities such as cardiovascular, antitumor, antibacterial, acricidal, insecticidal, plant-growth regulating, chitin biosynthesis inhibitors and monoamine oxidase inhibition [13][14][15][16][17][18][19][20][21][22][23].…”