BackgroundCoronavirus disease 2019 (COVID-19) is a serious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The primary manifestation is respiratory insu iciency that can also be related to di use pulmonary microthrombosis in people with COVID-19. This disease also causes thromboembolic events, such as pulmonary embolism, deep venous thrombosis, arterial thrombosis, catheter thrombosis, and disseminated intravascular coagulopathy. Recent studies have indicated a worse prognosis for people with COVID-19 who developed thromboembolism.Anticoagulants are medications used in the prevention and treatment of venous or arterial thromboembolic events. Several drugs are used in the prophylaxis and treatment of thromboembolic events, such as heparinoids (heparins or pentasaccharides), vitamin K antagonists and direct anticoagulants. Besides their anticoagulant properties, heparinoids have an additional anti-inflammatory potential, that may a ect the clinical evolution of people with COVID-19. Some practical guidelines address the use of anticoagulants for thromboprophylaxis in people with COVID-19, however, the benefit of anticoagulants for people with COVID-19 is still under debate. ObjectivesTo assess the e ects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and the need for respiratory support in people hospitalised with COVID-19. Search methodsWe searched CENTRAL, MEDLINE, Embase, LILACS and IBECS databases, the Cochrane COVID-19 Study Register and medRxiv preprint database from their inception to 20 June 2020. We also checked reference lists of any relevant systematic reviews identified and contacted specialists in the field for additional references to trials. Selection criteriaRandomised controlled trials (RCTs), quasi-RCTs, cluster-RCTs and cohort studies that compared prophylactic anticoagulants (heparin, vitamin K antagonists, direct anticoagulants, and pentasaccharides) versus active comparator, placebo or no intervention for the management of people hospitalised with COVID-19. We excluded studies without a comparator group. Primary outcomes were all-cause Prophylactic anticoagulants for people hospitalised with COVID-19 (Review)

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RESUMO: Objetivou identificar as complicações em pacientes renais crônicos submetidos à hemodiálise e correlacioná-las aos fatores sociodemográficos e clínicos. Estudo transversal, com 200 pacientes em uma clínica de nefrologia no Nordeste do Brasil. Utilizou-se um formulário para a coleta de dados, que ocorreu durante março e abril de 2015. Na análise inferencial, foram aplicados testes de Qui-Quadrado e Exato de Fisher, e U de Mann-Whitney, na associação entre variáveis nominais e numéricas. As associações estatísticas foram: hipotensão com idade, sexo e ganho de peso interdialítico; calafrios com sexo e ganho de peso interdialítico; vômito com sexo, sítio de diálise e KT/V; cefaleia com sexo e idade; tontura com anos de estudo, religião e ganho de peso interdialítico; arritmia e idade; diarreia e tempo de hemodiálise; dor abdominal e ganho de peso interdialítico; sudorese e idade. Conclui-se que complicações durante a hemodiálise podem sofrer influência de fatores sociodemográficos e clínicos. DESCRITORES: Enfermagem; Diálise renal; Complicações; Insuficiência renal; Perfil de saúde. COMPLICAÇÕES EM PACIENTES RENAIS CRÔNICOS SUBMETIDOS COMPLICATIONS IN PATIENTS WITH CHRONIC RENAL FAILURE UNDERGOING HEMODIALYSIS*ABSTRACT: The present study aimed to identify complications in patients with chronic renal failure undergoing hemodialysis and correlate them to socio-demographic and clinical factors. Cross-sectional study with 200 patients conducted in a nephrology clinic in the Northeast of Brazil. Data was collected in March and April 2015 through a structure questionnaire completed by the participants. Chi-square and Fisher's Exact tests were performed in inferential analysis, and Mann-Whitney U test was used to assess the relationship between categorical (nominal) and numerical variables. The statistically significant associations were hypotension with age, gender and interdialytic weight gain; chills with gender and interdialytic weight gain; vomiting with gender, dialysis site and Kt/V; headache with gender and age; dizziness with years of schooling, religious belief and interdialytic weight gain; arrhythmia and age; diarrhea and length of time on dialysis treatment; abdominal pain and interdialytic weight gain; sweating and age. It is concluded that complications during hemodialysis can be affected by socio-demographic and clinical factors.

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This study analyzed the accuracy of clinical indicators of ineffective health management in hemodialysis patients. A diagnostic accuracy study was performed in 200 chronic kidney disease patients undergoing hemodialysis during the first half of 2015. Measures of sensitivity and specificity were calculated using latent class analysis. Ineffective health management was present in 66.28% of patients. Accurate clinical indicators included expressed nonadherence to treatment, daily life choices ineffective to achieve health goals, expression of difficulty with prescribed regimens, inappropriate use of medicines, lack of expression of willingness to control the disease, irregular attendance of dialysis sessions, and infection. Hemodialysis may trigger a set of clinical indicators that predict the presence of ineffective health management. This knowledge provides evidence to clinical practices for hemodialysis patients and contributes to the best clinical performance of nurse practitioners.

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Objectives To analyze the concept of virtual clinical simulation in nursing education. Methods The Walker and Avant concept analysis model guided the study process and the data collection followed the integrative literature review method. Databases searched were: CINAHL, PubMed, Education Resources Information Center, and Scopus. Search terms and Boolean operators were: e-simulation OR virtual clinical simulation OR computer-simulation OR computer simulation OR virtual gaming OR virtual reality AND nursing education OR nursing. The sample comprised 45 studies. Results Virtual clinical simulation in nursing education was defined as the innovative teaching and learning technological strategy that provides immersive self-regulated training of nursing practice, reproducing real-life experiences and feedback in a virtual environment that is safe, interactive, dynamic and enjoyable. Conclusions Clarification of this concept contributes to the development of a standardized terminology to include in the nursing nomenclature system and its dissemination for the construction of nursing science.