Hormone

Druckrey,

doi:10.1007/bf01620345

Cited by 2 publications

(2 citation statements)

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“…1AR6-1-RT7 has a shorter (3 weeks) average latent period than IAR6-I (9 weeks). Both lines give rise to pulmonary metastases [19-211. Animals BD-IV (H-ld) and BD-IX (H-ld) [22] rats were bred in our animal facility by brothersister mating. Pedigree stock of BD-IX rats were obtained from Dr. Mayo, Frederick Cancer Research Center.…”

Section: Cell Linesmentioning

confidence: 99%

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Introduction of metastatic heterogeneity by short‐term in vivo passage of a cloned transformed cell line

et al. 1979

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An experimental system for the study of metastasis has been developed using an epithelioid cell line of hepatic origin which had previously been chemically transformed in vitro. These metastatic cells were studied in the syngeneic rat strain. The cloned parent cell line metastasizes only to the lungs following intravenous, subcutaneous, or intraperitoneal injection. The metastatic phenotype is stable during in vitro passage, and subclones from the parent clone have a metastatic capacity statistically similar to that of the parent clone. Following ascites passage of the parent cell line, the cell population obtained exhibits the same metastatic ability as the parent clone. However, subclones obtained from the ascites-passaged population exhibit metastatic heterogeneity. This heterogeneity is introduced by the host passage and not by in vitro culture or subcloning. In the case of the two metastatic variants examined, the difference in the metastatic phenotype is found not to be due to differences in arrest or trapping of the cells but appears to be related to long-term survival and proliferation of the tumor cells following their arrest in the lungs. Morphologically the variants are very similar, and growth of the metastatic foci provokes a vigorous inflammatory response by the host.

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Section: Cell Linesmentioning

confidence: 99%

“…Animals 6-12 weeks of age were used for these studies. The BD-IV and BD-IX strains are not syngeneic but do have the same major histocompatability loci, and each permanently accepts skin grafts from the other strain [22].…”

Section: Cell Linesmentioning

confidence: 99%

Introduction of metastatic heterogeneity by short‐term in vivo passage of a cloned transformed cell line

et al. 1979

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Ichthyosis in a Nigerian Dwarf Goat

2014

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Abstract:A 4-year-old Nigerian Dwarf goat presented with a long history of nonpruritic, scaly skin noticed since it was acquired at 3 weeks of age. Dermatologic examination revealed widespread large, white, nonadherent scales covering the entire skin. Histopathologic findings were characterized by noninflammatory compact diffuse orthokeratotic hyperkeratosis. Oral vitamin A therapy resulted in an approximate 85% reduction of the scaling with no reports of adverse effects. This is the first reported case of ichthyosis in the goat. Oral vitamin A may be beneficial for the management of caprine ichthyosis.

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Hormone

Cited by 2 publications

References 0 publications

Introduction of metastatic heterogeneity by short‐term in vivo passage of a cloned transformed cell line

Introduction of metastatic heterogeneity by short‐term in vivo passage of a cloned transformed cell line

Ichthyosis in a Nigerian Dwarf Goat

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