Hormonal regulation of interleukin-6 production in human adipocytes

Vicennati, Valentina; Vottero, Alessandra; Friedman, Constance L.; Papanicolaou, DA

doi:10.1038/sj.ijo.0802035

Cited by 107 publications

(72 citation statements)

References 33 publications

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“…In accordance with these findings, IL-6 protein secretion was increased in human adipocytes in vitro and in vivo in volunteers after treatment with the β-adrenoceptor agonist isoprenaline [47,48,49]. Furthermore, insulin stimulates and glucocorticoids suppress IL-6 mRNA and protein expression in 3T3-L1 and human adipocytes (Table 1) [46,48,49,50]. In accordance with these in vitro results, diminished exercise-induced IL-6 plasma concentrations have been found after treatment with hydrocortisone or dexamethasone in vivo [51].…”

Section: Interleukin-6supporting

confidence: 54%

“…β-adrenergic activation stimulates IL-6 mRNA expression in 3T3-L1 adipocytes and this effect is mediated via a classic G S -protein-coupled pathway (Table 1) [46]. In accordance with these findings, IL-6 protein secretion was increased in human adipocytes in vitro and in vivo in volunteers after treatment with the β-adrenoceptor agonist isoprenaline [47,48,49]. Furthermore, insulin stimulates and glucocorticoids suppress IL-6 mRNA and protein expression in 3T3-L1 and human adipocytes (Table 1) [46,48,49,50].…”

Section: Interleukin-6mentioning

confidence: 72%

“…Furthermore, β-adrenergic activation rapidly decreases leptin expression and secretion in primary adipocytes in vitro and mice in vivo (Table 1) [117,118]. Insulin is a potent activator of leptin mRNA expression and protein secretion [49] and it is plausible that insulin is the major mediator of increased post-prandial leptin concentrations (Table 1) [119,120,121]. Furthermore, glucocorticoids stimulate leptin expression and secretion in vivo and in vitro (Table 1) [49,118,122].…”

Section: Leptinmentioning

confidence: 99%

“…Insulin is a potent activator of leptin mRNA expression and protein secretion [49] and it is plausible that insulin is the major mediator of increased post-prandial leptin concentrations (Table 1) [119,120,121]. Furthermore, glucocorticoids stimulate leptin expression and secretion in vivo and in vitro (Table 1) [49,118,122]. Of interest, this increase in leptin synthesis can be reversed by TZD treatment in humans [123].…”

Section: Leptinmentioning

confidence: 99%

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Regulation of adipocytokines and insulin resistance

2003

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It has long been known that obesity and insulin resistance are linked. Recently, it has been shown that adipocytes secrete several proteins including tumour necrosis factor-α, interleukin-6, resistin, and adiponectin. Since several of these so-called adipocytokines influence insulin sensitivity and glucose metabolism profoundly, they might provide a molecular link between increased adiposity and impaired insulin sensitivity. Thiazolidinediones which decrease insulin resistance and are used in the treatment of Type 2 diabetes seem to mediate part of their insulin-sensitising effects via modulation of adipocytokine expression.Furthermore, hormones such as β-adrenergic agonists, insulin, glucocorticoids, and growth hormone might impair insulin sensitivity at least in part via up-regulation or down-regulation of adipocytokine synthesis. We summarise the current knowledge on how major adipocyte-secreted proteins are regulated by hormones and drugs influencing insulin sensitivity and discuss its implications for insulin resistance and obesity. [Diabetologia (2003[Diabetologia ( ) 46:1594[Diabetologia ( -1603

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Section: Interleukin-6supporting

confidence: 54%

Section: Interleukin-6mentioning

confidence: 72%

Section: Leptinmentioning

confidence: 99%

Section: Leptinmentioning

confidence: 99%

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Regulation of adipocytokines and insulin resistance

2003

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“…In addition, the sympathetic nervous system may be an important regulator of the synthesis and release of IL-6 from adipocytes. 8 IL-6 release from cultured human adipocytes can be inhibited by glucocorticoids and induced by insulin, 9 and a short-term b-adrenergic stimulation elevates IL-6 concentrations by increased release from fat depots and muscle. 10 The influence of diet and its fatty acid composition on adipose tissue development and distribution is well known, 11,12 as is the close relation between nutrition-and adipose tissue-associated diseases.…”

Section: Introductionmentioning

confidence: 99%

Nutritional regulation of interleukin-6 release from adipocytes

et al. 2010

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Background and aims: As interleukin-6 (IL-6) has an important role in general metabolism with high circulating levels in obesity and other associated diseases, the factors regulating its synthesis and release have been considered possible therapeutic targets and have recently been studied. We examined the influence of three different diets, each having a different fatty acid compositionFsaturated, monounsaturated or polyunsaturated (coconut oil, olive oil and sunflower oil diets), on IL-6 release from rat adipocytes, and the interaction between diet and other regulatory factors of IL-6 release, such as epinephrine. Methods: A group of rats was assigned to one of the three different diets, each with a significantly different concentration of saturated, monounsaturated and polyunsaturated fatty acids. Samples were taken from the omental adipose tissue for measurement of the triacylglycerol fatty acid composition of the tissues and for adipocyte isolation. IL-6 release from adipocytes was measured in vitro, under nonstimulated conditions and also with two concentrations of epinephrine in the medium. Results: Animals fed with the olive oil diet showed lower values of IL-6 release with and without epinephrine stimulation. IL-6 release from adipocytes varied according to the diet, but not according to epinephrine dose. However, a significant interaction was found between the epinephrine dose and the diet in IL-6 release regulation. Conclusions: IL-6 release from adipocytes was markedly regulated by the dietary fatty acid composition, even under epinephrine stimulation, with lower values of IL-6 release in the olive oil diet. The study also showed that epinephrine regulation of IL-6 release was related to the diet.

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Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans

Hagman

Kuzma

et al. 2018

Comprehensive Physiology

276

241

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The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift towards more pro-inflammatory subtypes of leukocytes. The infiltration of pro-inflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C-C motif chemokine ligand 2, pro-inflammatory cytokines including tumor necrosis factor α and interleukins 1β and 6, as well as reduced expression of the key insulin sensitizing adipokine, adiponectin. In both rodent models and humans, adipose tissue inflammation is consistently associated with excess fat mass and insulin resistance. In humans, associations with insulin resistance are stronger and more consistent for inflammation in visceral as opposed to subcutaneous fat. Further, genetic alterations in mouse models of obesity that reduce adipose tissue inflammation are – almost without exception - associated with improved insulin sensitivity. However, a dissociation between adipose tissue inflammation and insulin resistance can be observed in very few rodent models of obesity as well as in humans following bariatric surgery- or low-calorie diet-induced weight loss, illustrating that the etiology of insulin resistance is multifactorial. Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues.

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Hormonal regulation of interleukin-6 production in human adipocytes

Cited by 107 publications

References 33 publications

Regulation of adipocytokines and insulin resistance

Regulation of adipocytokines and insulin resistance

Nutritional regulation of interleukin-6 release from adipocytes

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

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