1987
DOI: 10.1016/0003-9861(87)90129-9
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Hormonal regulation of dipeptidyl-aminopeptidase I activity in cultured human fibroblasts

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Cited by 2 publications
(2 citation statements)
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“…That this enzyme, which had a digitonin solubilization profile comparable to that of the lysosomal marker enzyme, is inactivated by cysteine peptidase inhibitors and by diprotin B, appears not to cleave Boc-Ala-Ala-pNA or Ala-pNA supports the hypothesis that cleavage of Ala-Ala-pNA is due to a cysteine-type dipeptidyl aminopeptidase. Dipeptidyl aminopeptidases have been detected and characterized in other organisms (Davis, 1987;Hui, 1988), although, to our knowledge, this is the first evidence for the occurrence of such an enzyme in a trypanosomatid. Cleavage of Boc-Ala-Ala-pNA, on the other hand, has characteristics of a cytosolic serine peptidase.…”
Section: Discussionmentioning
confidence: 74%
“…That this enzyme, which had a digitonin solubilization profile comparable to that of the lysosomal marker enzyme, is inactivated by cysteine peptidase inhibitors and by diprotin B, appears not to cleave Boc-Ala-Ala-pNA or Ala-pNA supports the hypothesis that cleavage of Ala-Ala-pNA is due to a cysteine-type dipeptidyl aminopeptidase. Dipeptidyl aminopeptidases have been detected and characterized in other organisms (Davis, 1987;Hui, 1988), although, to our knowledge, this is the first evidence for the occurrence of such an enzyme in a trypanosomatid. Cleavage of Boc-Ala-Ala-pNA, on the other hand, has characteristics of a cytosolic serine peptidase.…”
Section: Discussionmentioning
confidence: 74%
“…The induction of brush border enzymes such as aminopeptidase N (EC 3.4.11.2) in the small intestine of developing animals by corticosteroids is well known [21]. Corticosteroids increase also the activities of such as angiotensin converting enzyme (ACE) in rabbit macrophages in cultures [22] and cathepsin C in cultured human fibroblasts [23]. In addition, physiological levels of cortisol (30 nM to 3 µM) increased aminopeptidase N, P-LAP and APA activities in placental tissue culture [24].…”
Section: Relationship Among Sex Steroids Aps and Fetal Peptide Hormomentioning
confidence: 99%