HOR7, a Multicopy Suppressor of the Ca2+-induced Growth Defect in Sphingolipid Mannosyltransferase-deficient Yeast

Lisman, Quirine; Urli-Stam, Dorothy; Holthuis, Joost C. M.

doi:10.1074/jbc.m406197200

Cited by 9 publications

(5 citation statements)

References 43 publications

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“…Another would be the direct interaction of Ca ++ with IPC or its role as a signaling molecule in a yet undiscovered pathway. The overexpression of HOR7 was able to counteract the calcium sensitivity of IPC accumulating cells by depolarizing the plasma membrane (88). IPCs have also been implicated as regulators of cell cycle.…”

Section: Downstream Of Dihydroceramides: Complex Sphingolipidsmentioning

confidence: 98%

Sphingolipid signaling in yeast potential implications for understanding disease

Epstein

Riezman²

2013

Front Biosci

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Sphingolipids are essential components of membranes and important for cellular integrity. The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway are highly conserved among fungal, plant and the animal kingdoms. The yeast model is a valuable system for the understanding of pathways and development of tools that will help to better understand and intervene into the molecular mechanisms controlling health and disease. Different classes of sphingolipids have been shown to act in different pathways. Sphingoid bases were shown to be involved in protection against a series of stresses such as heat shock, osmotic stress and low pH. Ceramides have been shown to be involved in G1 arrest, heat shock response and more recently as a target of the TORC 2. Complex sphingolipids are essential for cell wall integrity and proper localization of GPI anchored proteins.

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Section: Downstream Of Dihydroceramides: Complex Sphingolipidsmentioning

confidence: 98%

Sphingolipid signaling in yeast potential implications for understanding disease

Epstein

Riezman²

2013

Front Biosci

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“…1) are sensitive to 100 mM calcium and this phenotype has played a key role in identifying genes in sphingolipid metabolism. 33, 34, 62, 63 Why mutants defective in CSG1 or CSG2 are sensitive to calcium is unclear, but it indicates a connection of some type between sphingolipids and calcium metabolism or signal transduction and these potential connections are presented below in the section on Signal Transduction Pathways.…”

Section: Membrane-associated Functions and Processesmentioning

confidence: 99%

Roles for Sphingolipids in Saccharomyces cerevisiae

Dickson

2010

Advances in Experimental Medicine and Biology

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Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.

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“…Among the 16 genes induced an hour after the dissolved oxygen impulse (cluster 3), several were related to stress response, such as HOR7 – whose overexpression increases yeast resistance to high salt concentration (Lisman et al ., ) – and TSL1 , involved in trehalose biosynthesis (Bell et al ., ). Trehalose accumulates in yeast under stress conditions (Li et al ., ).…”

Section: Resultsmentioning

confidence: 99%

Metabolic and transcriptomic response of the wine yeastSaccharomyces cerevisiaestrain EC1118 after an oxygen impulse under carbon-sufficient, nitrogen-limited fermentative conditions

et al. 2014

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During alcoholic fermentation, Saccharomyces cerevisiae is exposed to continuously changing environmental conditions, such as decreasing sugar and increasing ethanol concentrations. Oxygen, a critical nutrient to avoid stuck and sluggish fermentations, is only discretely available throughout the process after pump-over operation. In this work, we studied the physiological response of the wine yeast S. cerevisiae strain EC1118 to a sudden increase in dissolved oxygen, simulating pump-over operation. With this aim, an impulse of dissolved oxygen was added to carbon-sufficient, nitrogen-limited anaerobic continuous cultures. Results showed that genes related to mitochondrial respiration, ergosterol biosynthesis, and oxidative stress, among other metabolic pathways, were induced after the oxygen impulse. On the other hand, mannoprotein coding genes were repressed. The changes in the expression of these genes are coordinated responses that share common elements at the level of transcriptional regulation. Beneficial and detrimental effects of these physiological processes on wine quality highlight the dual role of oxygen in 'making or breaking wines'. These findings will facilitate the development of oxygen addition strategies to optimize yeast performance in industrial fermentations.

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HOR7, a Multicopy Suppressor of the Ca2+-induced Growth Defect in Sphingolipid Mannosyltransferase-deficient Yeast

Cited by 9 publications

References 43 publications

Sphingolipid signaling in yeast potential implications for understanding disease

Sphingolipid signaling in yeast potential implications for understanding disease

Roles for Sphingolipids in Saccharomyces cerevisiae

Metabolic and transcriptomic response of the wine yeastSaccharomyces cerevisiaestrain EC1118 after an oxygen impulse under carbon-sufficient, nitrogen-limited fermentative conditions

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