Hookah smoking is strongly associated with diabetes mellitus, metabolic syndrome and obesity: a population-based study

Soflaei, Sara Saffar; Darroudi, Susan; Tayefi, Maryam; Tirkani, Abolfazl Nosrati; Moohebati, Mohsen; Ebrahimi, Mahmoud; Esmaily, Habibollah; Parizadeh, Seyed Mohammad Reza; Heidari‐Bakavoli, Alireza; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1186/s13098-018-0335-4

Cited by 18 publications

(59 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to common misconception, serious health effects are related to WP use. Epidemiological studies have shown that WP smoking is associated with increased risks of cardiovascular diseases,6 cancer (lung, oesophageal, head and neck, and gastric),7–10 metabolic syndrome11 and chronic obstructive pulmonary disease (COPD) 12. An additional health risk that is of particular concern for young adults is nicotine dependence, and similar to any other tobacco product is represented in WP smokers by substance addiction behaviours 13–19.…”

Section: Introductionmentioning

confidence: 99%

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

et al. 2019

View full text Add to dashboard Cite

ObjectiveWe investigated the effects of chronic waterpipe (WP) smoke on pulmonary function and immune response in a murine model using a research-grade WP and the effects of acute exposure on the regulation of immediate-early genes (IEGs).MethodsWP smoke was generated using three WP smoke puffing regimens based on the Beirut regimen. WP smoke samples generated under these puffing regimens were quantified for nicotine concentration. Mice were chronically exposed for 6 months followed by assessment of pulmonary function and airway inflammation. Transcriptomic analysis using RNAseq was conducted after acute exposure to characterise the IEG response. These biomarkers were then compared with those generated after exposure to dry smoke (without water added to the WP bowl).ResultsWe determined that nicotine composition in WP smoke ranged from 0.4 to 2.5 mg per puffing session. The lung immune response was sensitive to the incremental severity of chronic exposure, with modest decreases in airway inflammatory cells and chemokine levels compared with air-exposed controls. Pulmonary function was unmodified by chronic WP exposure. Acute WP exposure was found to activate the immune response and identified known and novel IEG as potential biomarkers of WP exposure.ConclusionChronic exposure to WP smoke leads to immune suppression without significant changes to pulmonary function. Transcriptomic analysis of the lung after acute exposure to WP smoke showed activation of the immune response and revealed IEGs that are common to WP and dry smoke, as well as pools of IEGs unique to each exposure, identifying potential biomarkers specific to WP exposure.

show abstract

Section: Introductionmentioning

confidence: 99%

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In 2018, a different group investigated the effects of cigarette smoking and water‐pipe smoking on biochemical properties such as RDW in a representative population sample obtained from a cohort study. Interestingly, after multivariate analysis, RDW was significantly higher in smokers compared to nonsmokers and among water‐pipe smokers compared to cigarette smokers (Saffar Soflaei et al, ). A review of the impact of physical activity on endothelium and ED revealed that endothelial damage was closely associated with ED and was also associated with cardiovascular disease (CVD).…”

Section: Discussionmentioning

confidence: 99%

The predictive value of red cell distribution width on erectile dysfunction

et al. 2019

View full text Add to dashboard Cite

Red cell distribution width (RDW), one of the biomarkers used to measure vascular ageing, is known to correspond with cardiovascular diseases. As coronary artery disease and erectile dysfunction (ED) are both caused by the same shared pathophysiology, in this study, we compared the RDW values of men diagnosed with ED and those of healthy controls. Ninety‐nine patients who were diagnosed with ED were included in the study. The control group consists of 100 men who presented to our outpatient clinic. Patients' fasting blood glucose, triglyceride, total cholesterol and LDL cholesterol levels were significantly higher in men diagnosed with ED. While the mean RDW value was 13.49 ± 1.52 in men with ED, it was 12.91 ± 1.13 in the control group. When RDW values were compared between the two groups, the RDW values of men with ED were found to be statistically significantly higher. Multivariate analyses showed that only the patients' body mass index, fasting blood sugar, triglyceride (TG), low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol levels (HDL‐C), TG/HDL‐C ratio and RDW levels' relationship with ED was statistically significant. Although some studies have shown that RDW may be related to some diseases such as cardiovascular diseases and cancer, this appears to be the first study demonstrating a relationship between RDW and ED. RDW can be utilised as a predictor for the determination of the presence and monitoring of the severity of ED.

show abstract

“…No difference was observed between waterpipe smokers and non-smokers regarding body mass index (BMI) in our metaanalysis. However, two population-based cross-sectional studies observed a significant association between obesity and each of regular waterpipe smokers (OR = 1.44; 95% CI: 1.26 to 1.65; P < 0.001) (Saffar Soflaei et al, 2018) and daily waterpipe smokers (OR = 2.87; 95% CI: 1.06 to 7.76; P = 0.038) (Ward et al, 2015), but no significant correlation was observed in a hospital based cross-sectional study (Selim et al, 2013b).…”

Section: Body Mass Indexmentioning

confidence: 95%

“…In one study, Nitric oxide (NO) metabolites were measured in waterpipe smokers (Ghasemi et al, 2010) demonstrating higher levels than in non-smokers (34.3 vs. 22.5 micromol/l; P < 0.01). No difference was observed regarding C-reactive protein (CRP) in three studies (Diab et al, 2015;Khan et al, 2020;Saffar Soflaei et al, 2018).…”

Section: Oxidative Status Inflammation and Vascular Function 342mentioning

confidence: 99%

Cardiovascular effects of waterpipe smoking: a systematic review and meta-analysis

Ali¹,

Vukadinović²,

Maziak³

et al. 2020

Reviews in Cardiovascular Medicine

View full text Add to dashboard Cite

Waterpipe smoking has developed into a major and rapidly growing global tobacco epidemic affecting more than 100 million people worldwide. This study identifies and analyzes comprehensively all available data on the cardiovascular effects of waterpipe smoking. Databases PubMed, EMBASE, Web of Science, and the Cochrane Library were searched for studies published until December 2019 assessing cardiovascular effects of waterpipe smoking. We included experimental, cohort, cross-sectional and case-control studies and excluded systematic reviews, case reports/series and qualitative studies. Studies not conducted in humans or not distinguishing waterpipe smoking from other forms of smoking were also excluded. A total of 42 studies with 46 cardiovascular parameters were eligible for analysis. The meta-analysis included 31 studies with 38,037 individuals. Results showed that one waterpipe smoking session leads to immediate increases in heart rate and blood pressure (P < 0.001). Compared to non-smokers, waterpipe smokers had significantly lower high-density lipoprotein levels (P < 0.001), higher levels of low-density lipoprotein (P = 0.04), triglyceride (P < 0.001) and fasting blood glucose (P = 0.03) and higher heart rate (P = 0.04) with a tendency to have higher blood pressure. Mean heart rate, blood pressure and lipids levels did not differ between waterpipe and cigarette smokers, except for total cholesterol, being higher among waterpipe smokers (P < 0.001). Current level of evidence suggests that waterpipe smoking is associated with substantial adverse effects on cardiovascular system, which seem to be similar to those of cigarette smoking. Longitudinal studies are required to scrutinize the magnitude of these effects.

show abstract

Hookah smoking is strongly associated with diabetes mellitus, metabolic syndrome and obesity: a population-based study

Cited by 18 publications

References 11 publications

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

Immune modulation by chronic exposure to waterpipe smoke and immediate-early gene regulation in murine lungs

The predictive value of red cell distribution width on erectile dysfunction

Cardiovascular effects of waterpipe smoking: a systematic review and meta-analysis

Contact Info

Product

Resources

About