Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress

Chen, Ying‐Ju; Wu, Chien Lin; Liu, Ju-Fang; Fong, Yi Chin; Hsu, Sheng Feng; Li, Te Mao; Su, Yi; Liu, Shing‐Hwa; Tang, Chih Hsin

doi:10.1016/j.canlet.2009.08.032

Cited by 55 publications

(43 citation statements)

References 42 publications

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“…In this study, we found that asterosaponin 1 significantly increased the expression of GRP78 in a dose and time-dependent manner, but with no effects on the expression of GRP94. It was reported that honokiol increased the expression of GRP78 but not GRP94 in human chondrosarcoma cells (29), which is similar to our finding in A549 cells, but another experiment in human gastric cancer cells indicated that honokiol induced GRP94 but not GRP78 cleavage (30). Transfection with targeting GRP78 siRNA resulted in up-regulation of GRP94 in HeLa cells, suggesting the compensational feature of GRP94 in the absence of GRP78 (31).…”

Section: Discussionsupporting

confidence: 90%

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Zhao

Zhu²,

Li³

et al. 2011

Oncol Rep

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Abstract. Asterosaponin 1, a new cytostatic agent from starfish, possesses several bioactivities including an antitumor effect. The aim of this study was to investigate the potential anti-proliferative and pro-apoptotic activity of asterosaponin 1 in A549 human lung cancer cells, as well as the potential mechanisms. The results showed that asterosaponin 1 inhibited the proliferation of A549 cells in a dose-dependent manner, and the cytostatic activity resulted from the induction of apoptotic cell death. Asterosaponin 1 increased ER dilation and cytosolic Ca 2+ concentration, and enhanced the expression of the ER molecular chaperones GRP78 and GRP94 in a doseand time-dependent manner. In addition, asterosaponin 1 treated A549 cells exerted increased expression and activity of CHOP, caspase-4 and JNK, three essential ER-associated apoptotic molecules. In summary, these results demonstrated that asterosaponin 1 inhibits the proliferation of A549 cells through induction of ER stress-associated apoptosis, making asterosaponin 1 a candidate new anticancer drug for lung cancer therapy.

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Section: Discussionsupporting

confidence: 90%

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Zhao

Zhu²,

Li³

et al. 2011

Oncol Rep

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“…Apart from that, inhibition of proteasomes prevents the activation of the transcription factor NF-κB, which makes cancer cells sensitive to cell death inducers [109, 110]. The effect of honokiol is similar to that of curcumin: it was also shown to promote mPTP opening and ROS accumulation [111]; although honokiol inhibits rather than induces MAPK/ERK signaling [112, 113] (Figure 2). Similar to IGF1R, curcumin and honokiol activities are suppressed by Alix/AIP1 overexpression, inhibitors of transcription/translation, antioxidants, and inhibitors of the JNK/SAPK and (for curcumin) MAPK/ERK pathways [94, 103, 114].…”

Section: Vacuolization and Known Cell Death Pathwaysmentioning

confidence: 99%

Cytoplasmic vacuolization in cell death and survival

et al. 2016

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Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mechanisms of the vacuole formation and structure have become available. In addition, numerous examples of the association between vacuolization and previously unknown cell death types have been reported. Here, we review these data to make a deeper insight into the role of cytoplasmic vacuolization in cell death and survival.

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“…anti-arrhythmic, anti-inflammatory, anti-thrombotic, anxiolytic, antimicrobial and other activities (Arora et al, 2012). Interestingly, honokiol inhibited growth of xenograft transplants derived from various tumor types in nude mice (Chen et al, 2004(Chen et al, , 2010Singh et al, 2013).…”

Section: Introductionmentioning

confidence: 97%

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking

et al. 2014

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Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress

Cited by 55 publications

References 42 publications

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells

Cytoplasmic vacuolization in cell death and survival

Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and molecular docking

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