Honey Versus Diphenhydramine for Post- Tonsillectomy Pain Relief in Pediatric Cases: A Randomized Clinical Trial

Amani, Soroush; Kheiri, Soleiman; Ahmadi, Ali

doi:10.7860/jcdr/2015/9784.5635

Cited by 7 publications

(31 citation statements)

References 9 publications

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“…They reported a higher reduction of postoperative pain in the honey group compared with other study groups, which is consistent with our observa-tions. A point of difference is that, in addition to considering pain during resting and swallowing in the present study, the follow-up period was one week in which 85% of patients in the honey group had no pain or considerably slight pain on the seventh day postoperatively (17). Likewise, Mohebi et al compared the impact of honey on re- duced pain in children after tonsillectomy in honey and control groups and showed that honey was effective in reducing postoperative pain, which is in line with this study; in the former, however, patients received oral honey while in the latter, normal saline mixed with honey was gargled for further contact of honey with the throat mucus (20).…”

Section: Discussionmentioning

confidence: 91%

“…Sample size was estimated based on a similar study (17). Samples were divided into three groups using block randomization and six blocks were assigned to three groups 2 Iran Red Crescent Med J.…”

Section: Discussionmentioning

confidence: 99%

“…The questionnaire included demographic and specific surgical related variables such as sex, age, weight, duration of surgery, intraoperative bleeding, type of surgery (tonsillectomy or adenotonsillectomy), sleep status, parents' satisfaction with intervention, the amount of opioid drug received on the first and second days, and the severity of pain at the recovery period and 6, 12, 18, 24, 36, 48 hours, and 7 days after surgery during rest and swallow. The pain was assessed using Wong-Baker FACES Pain Rating Scale (WBS) with confirmed validity in previous Iranian and international studies, and a reliability of 0.93 measured with Cronbach's alpha (16)(17)(18). The WBS consists of two numerical and facial elements ranging from zero for children with a smiling "no-pain" face to 5 for those with a crying face, reflecting "no hurt" and "worst hurt," respectively.…”

Section: Methodsmentioning

confidence: 99%

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The Effect of Gargling Cold Normal Saline in Comparison to Normal Saline Mixed with Honey on Postoperative Pain Relief in Tonsillectomy or Adenotonsillectomy: A Randomized Clinical Trial

Raoufian¹,

Nasiri²,

Ghafari³

et al. 2020

Iran Red Crescent Med J

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Objectives: The present study was conducted to compare the effect of gargling normal saline mixed with honey and cold normal saline on postoperative pain relief in children undergoing tonsillectomy or adenotonsillectomy during 2018. Methods: This clinical trial was performed on 105 children aged 5-14 years. The participants were randomly allocated to three 35-member groups, viz. normal saline mixed with honey, cold normal saline, and the control. The patients underwent general anesthesia and then were operated by a single surgeon. Gargle was administered in the first and second groups every six hours up to 48 hours following the surgery. There was no intervention in the control group. The pain was recorded by the Wong-Baker FACES Pain Rating Scale (WBS) at the recovery time and 6, 12, 18, 24, 36, 48 hours and 7 days after the surgery. Data were analyzed using repeated measures ANOVA. Results: Among the participants, 47 subjects (44.8%) were males and the rest were females, with a mean age of 8.6 ± 2.5 years. The three groups were similar in terms of sex, weight, duration of surgery, and bleeding during surgery. The pain at the site of surgery during both resting and swallowing was different at 6, 12, 18, 24, 36, 48 hours, and 7 days following the surgery (P < 0.001). Conclusions: Gargling cold normal saline and normal saline mixed with honey led to reduced pain after tonsillectomy or adenotonsillectomy; however, the latter had a higher effect on the postoperative pain relief.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Effect of Gargling Cold Normal Saline in Comparison to Normal Saline Mixed with Honey on Postoperative Pain Relief in Tonsillectomy or Adenotonsillectomy: A Randomized Clinical Trial

Raoufian¹,

Nasiri²,

Ghafari³

et al. 2020

Iran Red Crescent Med J

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“…Honey has been used in wound care for thousands of years and has recently been shown to have antibacterial activity and wound‐healing capabilities . A recent Cochrane review identified two high‐quality trials that found honey dressings heal partial‐thickness burns 5 days faster than conventional dressings .…”

Section: Methodsmentioning

confidence: 99%

Treating pediatric post‐tonsillectomy pain and nausea with complementary and alternative medicine

2018

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At this time, stronger conclusions cannot be made about the therapies investigated because there are many methodology limitations of the studies analyzed. However, our results suggest merit for these treatments as adjuvant therapies that can enhance analgesia and decrease requirements of controversial medications. Honey and acupuncture have the greatest amount of evidence for postoperative pain and nausea; however, all interventions examined were cost-effective and safe. We recommend against hydrogen peroxide rinses and chewing gum. Laryngoscope, 2625-2634, 2018.

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“…Given cold climate, high altitude,high prevalence of sinusitis in Chaharmahal and Bakhtiari Province, lack of studies on patients referring hospitals in this topic in this province (Amani, Kheiri, & Ahmadi, 2015), and the availability of azithromycin and co-amoxiclav as two drugs of choice, this study was conducted to determine and compare the efficacy and side effects of azithromycin and co-amoxiclav.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Efficacy and Side Effects of Azithromycin and Co-Amoxiclav in the Treatment of Acute Sinusitis in Adults: A Randomized Clinical Trial

Amani¹,

Mohammadi-Najafabadi²,

Ahmadi³

2016

GJHS

Self Cite

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Background: Regarding high prevalence of common cold and sinusitis in Chaharmahal and Bakhtiari Province and the lack of studies on patients referring hospitals in this province, this study was conducted to determine and compare the efficacy and side effects of azithromycin and co-amoxiclav. Methods:This study was a double-blinded randomized clinical trial. The study population of this clinical trial was consisted of 90 patients with acute sinusitis aged 12-65 years. At least two major criteria or one major criterion and two minor criteria with duration of at least 7 days and at most 28 days, were some of the sinusitis diagnostic criteria for inclusion of the patients into the study. The patients were examined for symptoms prior to and twice after the treatment. The treatment was administration with 500 mg azithromycin tablet per day for three days in group 1 (G1) and 625 mg co-amoxiclav tablet every 8 h for 10 days in group 2 (G2). The data were analyzed by repeated measures analysis of variance, independent t-test, and chi-square in Stata software and P < 0.05 was considered significant. Results:Mean±Standard deviation age of all patients was 32.14±9.91 years. Out of 90 participants in the study, 50 (55.56%) were male and the rest were female. The patients' symptoms were quantitatively similar in the two groups (22.3±2 and 22.2±1.9 in G1 and G2, respectively) prior to the intervention. The score at second examination decreased to 3.7±2.1 in G1 and to 9.4±2.7 in G2, significantly different from that prior to intervention and between the two groups (P<0.001). Although the score decreased in the two groups at third examination, it was not significant in the two groups (P=0.652). The cure rate in azithromycin group was derived 87.5% and 88%, and in co-amoxiclav group 32.4% and 83.3% at the days 5 and 10 of treatment, respectively. The most prevalent side effects in the two groups were diarrhea and nausea. The prevalence of diarrhea was obtained 21% and 33% in G1 and G2, respectively. Conclusion:No significant difference in side effects was seen between the two groups. Although the cure was faster in the patients treated with azithromycin than those treated with co-amoxiclav, co-amoxiclav is still considered as adequately working against acute sinusitis bacterial pathogens. In view of this efficacy, co-amoxiclav seems to lead to no drug resistance and could be used to treat the patients.

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Honey Versus Diphenhydramine for Post- Tonsillectomy Pain Relief in Pediatric Cases: A Randomized Clinical Trial

Cited by 7 publications

References 9 publications

The Effect of Gargling Cold Normal Saline in Comparison to Normal Saline Mixed with Honey on Postoperative Pain Relief in Tonsillectomy or Adenotonsillectomy: A Randomized Clinical Trial

The Effect of Gargling Cold Normal Saline in Comparison to Normal Saline Mixed with Honey on Postoperative Pain Relief in Tonsillectomy or Adenotonsillectomy: A Randomized Clinical Trial

Treating pediatric post‐tonsillectomy pain and nausea with complementary and alternative medicine

Comparison of Efficacy and Side Effects of Azithromycin and Co-Amoxiclav in the Treatment of Acute Sinusitis in Adults: A Randomized Clinical Trial

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