Honey stimulates inflammatory cytokine production from monocytes

Tonks, Amanda Jayne; Cooper, Rose; Jones, Ken; Blair, Shona E.; Parton, Joan; Tonks, Alex

doi:10.1016/s1043-4666(03)00092-9

Cited by 384 publications

(313 citation statements)

References 30 publications

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“…24 It has well-established antioxidant and antimicrobial effects that have been suggested as the mechanism for honey' s efficacy in wound healing and may help to explain its superior results in this study. [16][17][18][19][20][21] The antioxidants present in honey come from a variety of sources, such as vitamin C, monophenolics, flavonoids, and polyphenolics. Although there is a wide spectrum of antioxidant types, monophenolics suchas 4-hydroxybenzoic and 4-hydroxycinnamic acids predominate in many honeys.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study

et al. 2012

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OBJECTIVES: To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs). METHODS: A survey was administered to parents on 2 consecutive days, first on the day of presentation, when no medication had been given the previous evening, and the following day, when the study preparation was given before bedtime, based on a double-blind randomization plan. Participants included 300 children aged 1 to 5 years with URIs, nocturnal cough, and illness duration of ≤7 days from 6 general pediatric community clinics. Eligible children received a single dose of 10 g of eucalyptus honey, citrus honey, labiatae honey, or placebo administered 30 minutes before bedtime. Main outcome measures were cough frequency, cough severity, bothersome nature of cough, and child and parent sleep quality. RESULTS: In all 3 honey products and the placebo group, there was a significant improvement from the night before treatment to the night of treatment. However, the improvement was greater in the honey groups for all the main outcome measures. CONCLUSIONS: Parents rated the honey products higher than the silan date extract for symptomatic relief of their children’s nocturnal cough and sleep difficulty due to URI. Honey may be a preferable treatment for cough and sleep difficulty associated with childhood URI.

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Section: Discussionmentioning

confidence: 99%

“…14 Honey has antioxidant properties and increases cytokine release, which may explain its antimicrobial effects. [16][17][18][19][20][21] The objective of this trial was to compare the effects on nocturnal cough and the sleep difficulty associated with URIs of a single nocturnal dose of 3 honey products compared with placebo.…”

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confidence: 99%

Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study

et al. 2012

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“…There have been many case reports and clinical trials proving their effectiveness against such bacteria, including the opportunistic human pathogen P. aeruginosa (Cooper et al, 2002;French et al, 2005;Molan, 2006). The honey antibacterial effects were mainly attributed to a combination of high osmolarity and bacteriocidal/ static activities, including hydrogen peroxide, phenolic compounds and antioxidants (Taormina et al, 2001;Cooper et al, 2002) as well as cytokine induction (Tonks et al, 2003;Simuth et al, 2004;Majtan et al, 2006). In parallel, there are searches for modern anti-bacterial adhesion strategies aimed at abrogating microbial (including P. aeruginosa) adhesion to host cells, preceding infection establishment (Gilboa-Garber, 1996;Sharon, 2006).…”

Section: Introductionmentioning

confidence: 99%

Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion

et al. 2007

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Pseudomonas aeruginosa antibiotic resistance has led to the search of natural compounds, which would competitively block its fucose4fructose/mannose-binding lectin (PA-IIL) that mediates its biofilm formation and adhesion to animal cells. Such compounds were found in human milk (HM) and avian egg whites. The present research has revealed that honey and royal jelly (RJ), which are assigned to protect beehive progeny and are applied for human infection therapy, match HM in PA-IIL blocking. The function of their fructose (higher in honey) and mannosylated glycoproteins (higher in RJ) as powerful decoys in PA-IIL neutralization is of ecological/biological importance and implementability for the antibacterial adhesion therapeutic strategy.

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“…the antimicrobial properties of honey are attributed to many factors, including acidity, hydrogen peroxide content, osmolarity and phytochemical components (MOOre et al, 2001). honey also reduces pain, as the pain in wounds results from the nerve endings being sensitized by prostaglandins produced in the process of inflammation, as well from pressure on the tissues resulting from edema (MOLaN, 2002;tONkS et al, 2001;tONkS et al, 2003).…”

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confidence: 99%

Observational study of the effect of L-Mesitran® medical honey on wound healing in cats

2018

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________________________________________________________________________________________Lukanc, B., T. PoTokar, V. ErjaVEc: Observational study of the effect of L-Mesitran ® medical honey on wound healing in cats. Vet. arhiv 88, 59-74, 2018.aBSTracT the aim of the study was to prove the healing effect of medical honey on contaminated nonsurgical wounds in cats. Ten cats with a total of fifteen contaminated nonsurgical wounds were included in the study. The wounds were treated with L-Mesitran ® Soft medical honey wound gel and left to heal by second intention. all wounds smaller than 10 cm 2 healed in 7 to 56 days (mean 30.8 ± 16.0 days), wounds larger than 10 cm 2 healed in 28 to 105 days (mean 64.4 ± 31.12 days). Wounds with skin and subcutis involvement (type 1) healed in 14 to 49 days (mean 29.17 ± 10.48 days), wounds where skin, subcutis and muscles, tendon and/or bones were involved (type 2) healed in 7 to 105 days (mean 50.6 ± 30.74 days). the scab and necrotic tissue gradually cleared from all wounds. Odour and exudate in all wounds vanished by day 7, while ph lowered from 7.6 to 7.0 in 3 days. The mean time of the first appearance of granulation tissue in wounds Type 1 was 3.66 ± 1.63 days and for wounds type 2 5.25 ± 2.55 days. the mean time to coverage of the bottom of the wound with granulation tissue was 3 to 18 days (mean 9.73 ± 5.11) days. Using the Mann-Whitney test, no statistically significant differences were found in healing of wounds between groups according to wound size and between groups according to the tissues involved on any of selected days (P<0.05). treatment of wounds with medical honey had a positive impact on wound healing, because the function of the affected part of the body was not impaired, the wounds healed without complications and the cosmetic appearance was minimally altered due to a minimal amount of scar tissue formation, and regrowth of the hair.

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Honey stimulates inflammatory cytokine production from monocytes

Cited by 384 publications

References 30 publications

Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study

Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study

Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion

Observational study of the effect of L-Mesitran® medical honey on wound healing in cats

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