Honey in modern wound care: A systematic review

Vandamme, Lynn; Heyneman, Alexander; Hoeksema, Henk; Verbelen, Jozef; Monstrey, Stan

doi:10.1016/j.burns.2013.06.014

Cited by 174 publications

(143 citation statements)

References 62 publications

(139 reference statements)

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“…17 The antibacterial and anti-inflammatory effects of honey have been reported in several studies. [18][19][20][21][22][23] In addition, honey contains vitamin C concentration three times more than plasma, 24 which could accelerate tissue regeneration. 25 A recent clinical trial showed the effectiveness of honey as a dressing for dry socket.…”

Section: 5005/jp-journals-10024-2210mentioning

confidence: 99%

“…27,28 In a recent review, it was demonstrated that honey could prevent cancerogenesis through alteration of cell cycle molecular processes 19 and some studies reviewed the effectiveness of honey for wound healing. 18,29,30 Although several studies demonstrated the soft tissue wound healing effect of honey, 18,23,29,30 its effect on bone defects has not been evaluated. Hence, the aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model.…”

Section: 5005/jp-journals-10024-2210mentioning

confidence: 99%

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Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Hajizadeh

Derakhshan

Peimani

et al. 2018

The Journal of Contemporary Dental Practice

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Aim: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancerogenic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. Materials and methods:This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05).Results: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). Effect of Topical Honey on Mandibular Bone Conclusion:The results showed that honey could accentuate bone healing of mandibular small defects in rats.Clinical significance: Honey might have potential in repair of human alveolar bone defects.

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Section: 5005/jp-journals-10024-2210mentioning

confidence: 99%

Section: 5005/jp-journals-10024-2210mentioning

confidence: 99%

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Hajizadeh

Derakhshan

Peimani

et al. 2018

The Journal of Contemporary Dental Practice

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“…2 O uso do mel é relatado desde a antiguidade em diversas partes do mundo e ainda hoje tem grande prestígio devido ao seu alto valor calórico e terapêutico. 3,4 Pode ser usado em substituição ao açúcar refinado, isoladamente ou associado a outros alimentos. 5 O Brasil encontra-se entre os grandes produtores e exportadores mundiais do mel, sendo este o principal produto da atividade apícola no país.…”

Section: Introductionunclassified

“…3 Além disso, são conhecidas as suas propriedades antioxidantes, inclusive seu uso como conservante natural dos alimentos: contra a oxidação lipídica de carnes 8,9 e na inibição do escurecimento enzimático de frutas, vegetais e sucos. 10 Possui também ação terapêutica antimicrobiana, antiúlcera, 3,4 antitumoral, 11 anti-inflamatória 12 e antiviral. 13 Vale ressaltar que as atividades do mel estão relacionadas a diversos fatores, entre eles seu alto teor de água e açúcares, baixo valor de pH, presença de peróxido de hidrogênio e diversos compostos provenientes do metabolismo secundário vegetal, entre eles os flavonides e os derivados fenólicos.…”

Section: Introductionunclassified

Evaluation of the Quality of Honey Commercialized in Western Pará, Brazil

Gomes¹,

Dourado²,

Dourado³

et al. 2017

Rev. Virtual Quim.

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Honey is a natural product of high nutritional and therapeutic value. Western of Pará State is a very promising beekeeping region, but the number of dealers who adulterate at least one of the produ t's ph si o he i al hara teristi s i reases as the eekeeping activity grows. Accordingly, the aim of the present study is to assess the quality of 09 samples of Jandaíra (Melipona compressipes manaoensis and Melipona seminigra) honey and 22 samples of Apis mellifera available for sale in west Pará, Brazil. It was observed that only 01 sample of honey from Jandaíra and 11 of Apis mellifera had all the assessed physicochemical parameters in compliance with the Brazilian legislation. With regard to the antioxidant activity against the DPPH radical, most of the samples had maximum inhibition values above 50% and such activity was greater in the darker staining samples. Finally, it was noteworthy that the adulterated honey or the honey outside the standard specifications lost their beneficial properties and shelf life longevity. Thus, its close monitoring in free and local markets is demanding.Keywords: Antioxidant activity; Moisture; Reducing sugars; Ashes; Color. ResumoO mel é um produto natural de alto valor nutricional e terapêutico, sendo a região oeste do Pará muito promissora na atividade apícola. Uma vez que esta atividade vem crescendo, aumenta também o número de comerciantes que adulteram o produto em pelo menos uma de suas características físico-químicas. Neste contexto, no presente trabalho foi avaliada a qualidade de 09 amostras de mel de Jandaíra (Melipona compressipes manaosensis e Melipona seminigra) e 22 amostras de mel de Apis mellifera comercializados na região oeste do Pará, Brasil. Dentre os parâmetros físico-químicos avaliados (cor, pH, teor de umidade, cinzas e açúcares redutores) observou-se que apenas 01 amostra de mel de Jandaíra e 11 de Apis mellifera apresentaram todos os parâmetros físico-químicos avaliados em acordo com a legislação brasileira. Em relação à atividade antioxidante frente ao radical DPPH, a maioria das amostras apresentou valores de inibição máximos acima de 50%, sendo esta atividade maior para as amostras de coloração mais escuras. Por fim, vale ressaltar que méis adulterados ou fora dos padrões implicam na perda de suas propriedades benéficas e diminuição de sua vida de prateleira, logo é necessária uma fiscalização maior do comércio deste produto em feiras e mercados locais.

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“…Due to modern bacterial rising of antibiotic resistance, an essential argument for honey use in wound therapy is the remarkable anti-infectious activity, without development of bacterial resistance or emergence of mutants resistant to honey [3][4][5][6].…”

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confidence: 99%

Honey, Food and Medicine: Scientific Rationale and Practical Efficiency in External Administration of Medicinal Honey for Wound Healing

Zbuchea¹

2017

JAST-B

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Except for its benefits as food and medicine, honey has been used since ancient times as an external remedy in wound care, and has been the subject of numerous studies and research, that reveal its complex favorable action for wound healing. Based on scientific research and clinical studies published in literature, this work presents these various properties and therapeutic activities of honey dressings. Next, actions and clinical effects of L-Mesitran range of dressings, based on medicinal honey and authorized European Union (EU) and Food and Drug Administration (FDA), have been highlighted in a case series of patients in the Department of Plastic Surgery, Emergency District Hospital of Ploiesti, Romania, by monitoring the clinical local evolution of burns and other wounds. L-Mesitran range of products is based on the combination of medicinal honey and other ingredients, such as hypoallergenic medicinal lanolin, vitamins C and E. These sterilized preparations were applied for various skin lesions after wound cleansing, and exerted a favorable action on healing of burns and other wounds, sometimes in combination with surgical treatment, being applied in these cases before or after surgery. Further clinical studies are needed to establish the best indications, methods and forms of administration for each type of wounds, as well as the selection over other types of dressings.

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Honey in modern wound care: A systematic review

Cited by 174 publications

References 62 publications

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Evaluation of the Quality of Honey Commercialized in Western Pará, Brazil

Honey, Food and Medicine: Scientific Rationale and Practical Efficiency in External Administration of Medicinal Honey for Wound Healing

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