Honey Bee Pharmacology

Davidson, Gigi

doi:10.1002/9781119583417.ch10

Cited by 3 publications

(36 citation statements)

References 47 publications

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“…34,118,136 The cuticle of the bee has a surface composed of hydrocarbons that can be crossed by many lipophilic compounds. 34 The wings are intensely vascularized and account for about a third of the surface area of the bee; thus, they are a potential route of exposure and absorption, particularly to volatilized pesticides. 100 Respiratory exposure and absorption are also likely when foragers are exposed to volatilized pesticides.…”

Section: Exposure and Absorptionmentioning

confidence: 99%

“…Metabolism of xenobiotics in insects, similar to vertebrates, utilizes phase I-III enzyme systems. 34,55 Metabolic enzymes in bees are located in the cuticle, fat body, Malpighian tubules of the excretory system, midgut, nervous system, and within mitochondria. 34,51,135 The fat body, in particular, serves a detoxification role similar to the liver.…”

Section: Metabolism and Elimination Pathwaysmentioning

confidence: 99%

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The role of the veterinary diagnostic toxicologist in apiary health

Bischoff,

Moiseff

2023

J VET Diagn Invest

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Susceptibility of individuals and groups to toxicants depends on complex interactions involving the host, environment, and other exposures. Apiary diagnostic investigation and honey bee health are truly population medicine: the colony is the patient. Here we provide basic information on the application of toxicology to the testing of domestic honey bees, and, in light of recent research, expand on some of the challenges of interpreting analytical chemistry findings as they pertain to hive health. The hive is an efficiently organized system of wax cells used to store brood, honey, and bee bread, and is protected by the bee-procured antimicrobial compound propolis. Toxicants can affect individual workers outside or inside the hive, with disease processes that range from acute to chronic and subclinical to lethal. Toxicants can impact brood and contaminate honey, bee bread, and structural wax. We provide an overview of important natural and synthetic toxicants to which honey bees are exposed; behavioral, husbandry, and external environmental factors influencing exposure; short- and long-term impacts of toxicant exposure on individual bee and colony health; and the convergent impacts of stress, nutrition, infectious disease, and toxicant exposures on colony health. Current and potential future toxicology testing options are included. Common contaminants in apiary products consumed or used by humans (honey, wax, pollen), their sources, and the potential need for product testing are also noted.

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Section: Exposure and Absorptionmentioning

confidence: 99%

Section: Metabolism and Elimination Pathwaysmentioning

confidence: 99%

The role of the veterinary diagnostic toxicologist in apiary health

Bischoff,

Moiseff

2023

J VET Diagn Invest

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“…Two factors are implicated in the occurrence of hazards related to acaricidal residues in bee products. Firstly, substances that facilitate dissolution of a drug or chemical greatly enhance the likelihood of absorption [ 18 ] and residue occurrence in propolis. Secondly, it has been estimated that, in propolis, pesticides resulting from beekeeping procedures are usually present at higher concentrations than those of environmental origin [ 30 ].…”

Section: Vmps Residues In Propolismentioning

confidence: 99%

“…Organic acids are non-volatile and water soluble. Thymol is volatile, water soluble, and moderately lipophilic [ 18 ]. Both are natural plant constituents, and in low concentrations they are present in honey.…”

Section: Vmps Residues In Propolismentioning

confidence: 99%

“…However, despite potential natural exposure to a broad diversity of phytochemicals, their genome is characterized by a paucity of genes associated with detoxification [ 17 ]. As they lack liver, kidneys, spleen, and lungs the role of excretion is taken over by the fat body, the Malphigian tubules, the hindgut, and the cuticle [ 18 ]. The negative effects of acaricides on honey bees may be discussed, with direct post-application effects corelated with such factors as the age of the bees, stress levels, temperature, physiological differences (queen/worker), mobility, and acaricide dose.…”

Section: Introductionmentioning

confidence: 99%

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Propolis Contra Pharmacological Interventions in Bees

Wojtacka

2022

Molecules

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In addition to wax, propolis is a mixture of resins, terpenes, and etheric and aromatic oils. This composition supports its very strong biochemical activity that affects bee health. Bee colonies are externally exposed to the activity of other different pharmacologically active substances and toxic agents used in beekeeping procedures, veterinary interventions, and the environment. Even if free form common diseases, they may suffer from parasites or toxins. In any such case the abundance and variety of honeyflow, besides proper therapy, is crucial for the maintenance of bee health. Propolis itself cannot be considered as food but can be considered as micro-nutrients for bees. This is due to the fact that some of its compounds may penetrate different bee products, and this way be consumed by bees and their larvae, while stored in the hive. This perspective shows propolis as natural agent reducing the toxicity of pyrethroid acaricides, stimulating production of detoxification enzymes, enhancing the action of antibiotics, and increasing expression of genes that encode proteins responsible for detoxication. The aim of this review is to summarize current data on the possible impact on veterinary public health of the introduction into propolis of residues of pharmacological agents approved in the EU for use in the treatment of bee colonies and their environment.

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Reminiscences on the honeybee genome project and the rise of epigenetic concepts in insect science

Maleszka

2024

Insect Molecular Biology

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The sequencing of the honeybee genome in 2006 was an important technological and logistic achievement experience. But what benefits have flown from the honeybee genome project? What does the annotated genomic assembly mean for the study of behavioural complexity and organismal function in honeybees? Here, I discuss several lines of research that have arisen from this project and highlight the rapidly expanding studies on insect epigenomics, emergent properties of royal jelly, the mechanism of nutritional control of development and the contribution of epigenomic regulation to the evolution of sociality. I also argue that the term ‘insect epigenetics’ needs to be carefully redefined to reflect the diversity of epigenomic toolkits in insects and the impact of lineage‐specific innovations on organismal outcomes. The honeybee genome project helped pioneer advances in social insect molecular biology, and fuelled breakthrough research into the role of flexible epigenomic control systems in linking genotype to phenotype.

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Honey Bee Pharmacology

Cited by 3 publications

References 47 publications

The role of the veterinary diagnostic toxicologist in apiary health

The role of the veterinary diagnostic toxicologist in apiary health

Propolis Contra Pharmacological Interventions in Bees

Reminiscences on the honeybee genome project and the rise of epigenetic concepts in insect science

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