Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer

Rashad, U M; Al-Gezawy, Samy; Elgezawy, Ebtesam; Azzaz, A N

doi:10.1017/s0022215108002478

Cited by 113 publications

(101 citation statements)

References 14 publications

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“…Biswall et al 9 were the first to use topical honey to successfully manage mucositis due to radiation. Rashad et al 12 reported that prophylactic natural honey is effective in reducing mucositis resulting from radiochemotherapy in patients with head and neck cancer. Our study demonstrated that RJ50 protects against hematological indices.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis is clinical and based on the use of known stomatotoxic therapy along with the timing and location of oral lesions. 6,[8][9][10][11][12][13][14] For several decades, there have been publications which have pointed to the potential of antioxidants to reduce mucosa damage induced by ionizing radiation. Some naturally occurring antioxidants have the advantage of offering an extended window of protection against low-dose and low-dose rate irradiation, including therapeutic potential when administered after irradiation.…”

Section: Introductionmentioning

confidence: 99%

“…Some naturally occurring antioxidants have the advantage of offering an extended window of protection against low-dose and low-dose rate irradiation, including therapeutic potential when administered after irradiation. 9,12,13 In addition, further studies are required to determine the potential value of specific antioxidant nutrients during radiotherapy for cancer. The use of antioxidants, such as vitamin E, and zinc sulfate, for the prevention of oral mucositis in RT or chemoradiation is promising but more research is needed.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Cihan¹

2014

UHOD

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The purpose of this study was to investigate the effects of royal jelly against radiation-induced oral mucositis in rats. This study was comprised of 48 adult male Sprague-Dawley rats, each between eight and 12 weeks old and weighing 275±35 g. These were divided randomly into six groups; Group C (control), Group IR (irradiation), Group IR+RJ50 (irradiation plus 50 mg/kg royal jelly), Group IR+RJ100 (irradiation plus 100 mg/kg royal jelly), Group RJ50 (50 mg/kg royal jelly), and Group RJ100 (100 mg/kg royal jelly). The degree of mucositis, the animal's body mass, and food intake were evaluated. Biochemical and histopathological methods were utilized for the evaluation of mucositis, and a hemogram, oxidative stress markers, and biochemical parameters were analyzed. Tongue samples were also processed for histopathological examination. Irradiation significantly increased oral mucositis, decreased the thrombocyte and neutrophil counts, and resulted in a reduction of food intake accompanied by weight loss. In addition, a significant increase in malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and catalase (CAT) activities were found (p< 0.001). Irradiation plus 50 mg/kg royal jelly caused normalization in the quantitative, biochemical, and histopathological parameters compared with the group that underwent irradiation alone.Irradiation plus 100 mg/kg royal jelly did not provide superior radioprotection against radiation-induced toxicities. Royal jelly was administered orally to reduce oral mucositis as it may be more suitably applied. International Journal of Hematology and Oncology INTRODUCTION Radiotherapy (RT) is an essential therapeutic modality in the management of head and neck cancers. Despite advances in RT technology, oral mucositis has not been ameliorated in head and neck cancer patients treated with radiotherapy. The current head and neck radiotherapy protocols have a mucositis incidence of 85-100%. The severity of mucositis depends on many variables, such as anti-cancer treatment protocol, age, diagnosis of the patient, level of oral hygiene during therapy, and genetic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Cihan¹

2014

UHOD

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“…Several studies were used topically applied honey for treatment of oral mucositis like Biswal et al [15], Motallebnejad et al [10], Rashad et al [16], Khanal et al [17], Abdulrhman et al [18] and Sedighi et al [19]. They showed that topically applied honey produced faster healing in patients with oral mucositis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

Refai¹

2014

J Cytol Histol

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“…Rashad's study demonstrated that topical application of honey on the oral mucosa 15 minutes before, 15 minutes after, and 6 hours after radiation would cause a significant reduction in radiation induced mucositis. Although there are few reports on the preventive effects of honey in mucositis, most of them have investigated patients who have received radiation therapy for head and neck cancer (1,(18)(19)(20)(21)(22)(23)(24)(25). This study added new information about other high risk patients who undergo induction chemotherapy for leukemia.…”

Section: Control No (%)mentioning

confidence: 99%

Antimicrobial Activity of Natural Honey: Topical Application of Pure Natural Honey in Prevention of Chemotherapy Induced Oral Mucositis

et al. 2013

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Background: Oral mucositis is a frequent problem after high-dose chemotherapy which could impair patient's quality of life, higher rates of infections, and delay in subsequent chemotherapy. Objectives: The present study was performed to assess the effect of topical application of pure natural honey in prevention of chemotherapy induced mucositis in patients with cancer. Patients and Methods:In this randomized clinical trial 48 patients with acute leukemia requiring chemotherapy were assigned to three equal groups. During induction or reinduction period of chemotherapy, first group received honey plus normal saline; the second one received just normal saline and third, (in control group) did not receive any prophylaxis. Patients were evaluated weekly for progression of mucositis according to the WHO mucositis scale. Data were analyzed with the Pearson Chi-Square and Fisher Exact test, by fifteen edition of SPSS software. Results: In group of 'honey plus normal saline' no patients developed mucositis, while in normal saline group 4 patients and in control group 12 patients developed mucositis. The rate of mucositis was significantly lower in both intervention groups compared to control (P < 0.001). Conclusions: This study demonstrates that using either honey or normal saline can reduce the rate and severity of chemotherapy induced mucositis.

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Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer

Abstract: This study shows that prophylactic use of pure natural honey was effective in reducing mucositis resulting from radiochemotherapy in patients with head and neck cancer.

Cited by 113 publications

References 14 publications

The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

The Effects of Royal Jelly Against Radiation-Induced Acute Oral Mucositis.

Effects of Kurdistan Honey on the Tongue of Chemotherapy Treated Albino Rats (Immunohistochemical Study)

Antimicrobial Activity of Natural Honey: Topical Application of Pure Natural Honey in Prevention of Chemotherapy Induced Oral Mucositis

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