Honey and obesity-related dysfunctions: a summary on health benefits

Terzo, Simona; Mulè, Flavia; Amato, Antonella

doi:10.1016/j.jnutbio.2020.108401

Cited by 46 publications

(37 citation statements)

References 101 publications

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“…However, despite the many hypotheses on the mechanisms for the numerous beneficial effects, honey's full potential has started to be unlocked only recently, with more comprehensive characterisations of its physicochemical composition (as described in Section 2 of this paper), and the further investigation of the medical activity of natural bioactive compounds also found in honey [6][7][8][9][10][11][12][13][14][15]. Honey has been shown to possess beneficial properties with diverse applications in otorhinolaryngology [16,17], respiratory tract diseases [18,19], cardiovascular diseases [20][21][22], metabolic disorders [23][24][25][26], oncology [27,28]. However, the focus of this review is on the use of honey in the management and treatment of skin disease and in particular wounds of various natures, exploring the possible mechanisms by which honey may enhance skin regeneration.…”

Section: Introductionmentioning

confidence: 99%

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

2021

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Honey is a honey-bee product obtained mainly by the enzymatic processing of nectar from a variety of plants, which leads to the wide range of colours and flavours available on the market. These organoleptic and nutritional features are influenced by the chemical composition, which in turn depends on the botanical origin. Bioactive compounds account for honey beneficial activity in medical applications, which explains the extensive use of honey in ethno-pharmacology since antiquity, from cough remedies to dermatological treatments. Wound healing is one of the main therapeutic uses of honey, and various design options in pharmaceutical technology such as smart delivery systems and advanced dressings are currently being developed to potentiate honey’s valuable properties for better performance and improved final outcome. In this review, we will focus on the latest research that discloses crucial factors in determining what properties are most beneficial when considering honey as a medicinal product. We will present the most recent updates on the possible mechanisms responsible for the exceptional effects of this ageless therapeutical remedy on skin repair. Furthermore, the state-of-the-art in application techniques (incorporation into scaffolds as an alternative to direct administration) used to enhance honey-mediated wound-healing properties are explored.

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Section: Introductionmentioning

confidence: 99%

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

2021

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“…Proteins include enzymes such as invertase, diastase, glucose oxidase, catalase, peroxidase and acid phosphatase, and their content varies from 0.1% to 3.3% depending on the type of honey. It contains essential and non-essential amino acids, but the most common amino acid in honey is proline, which accounts for 1% of honey components [2]. Honey contains tocopherol (E), anti-hemorrhagic vitamin (K), ascorbic acid (C), thiamine (B 1 ), riboflavin (B 2 ), niacin (B 3 ), pantothenic acid (B 5 ) and a small amount of vitamin pyridoxine (B 6 ).…”

Section: Physical and Chemical Properties Of Honeymentioning

confidence: 99%

“…Acids contribute to the aroma and antimicrobial activity of honey. The predominant acid in honey is gluconic acid, it is followed by aspartic citric, acetic, formic, fumaric, galacturonic, malonic, formic, acetoglutaric, glutamic, butyric, glutaric, propionic, pyruvic, glioxia, 2-hydroxybutyric, a-hydroxiglutaric, isocyric, lactic, malic, methylmalonic, kynic, succinic, tartaric, oxalic acid [2]. The mineral content in honey ranges from 0.04% in light honey and 0.2% in dark honey.…”

Section: Physical and Chemical Properties Of Honeymentioning

confidence: 99%

“…However, the composition of honey largely depends on a number of factors, such as flower source, geographical region, climatic conditions, harvesting season, processing and storage conditions. There are studies that report that honey, administered alone or in combination with traditional therapy, may be useful in the treatment of chronic diseases that are commonly associated with oxidative stress and the state of inflammation [2]. Honey is classified according to various criteria.…”

Section: Introductionmentioning

confidence: 99%

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Honey Production Process

Dümen¹,

Tarakçı²,

Ekici³

2022

A Glance at Food Processing Applications

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Honey has been considered as a very important and superior nutrient in human nutrition since ancient times due to its ability to be consumed by humans without processing, easy digestibility, nutritional properties and biological benefits. Although honey contains many desired bioactive and antibacterial substances, which may be sufficient for antimicrobial activity, it cannot be produced in sufficient quantities due to low water activity under normal conditions. This causes various food and bee-borne spores/non-spores pathogens going viral. Hence, it may cause the risk of parasitological and fungal agents to be found. In honey production, “Hazard Analysis Critical Control Point (HACCP)” must be applied meticulously and completely. Current technologies in honey production will be explained in this section.

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“…Flavonoids present in honey, such as quercetin and kaempferol, show promising results in the treatment of cardiovascular diseases [ 112 ]. A study by Sanchez and colleagues reported that treatment with 10 mg/kg of quercetin for 13 weeks lowered blood pressure and heart rate in spontaneously hypertensive rats.…”

Section: The Mechanisms Of Honey In Reversing Metabolic Changesmentioning

confidence: 99%

The Mechanism of Honey in Reversing Metabolic Syndrome

2021

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Metabolic syndrome is a constellation of five risk factors comprising central obesity, hyperglycaemia, dyslipidaemia, and hypertension, which predispose a person to cardiometabolic diseases. Many studies reported the beneficial effects of honey in reversing metabolic syndrome through its antiobesity, hypoglycaemic, hypolipidaemic, and hypotensive actions. This review aims to provide an overview of the mechanism of honey in reversing metabolic syndrome. The therapeutic effects of honey largely depend on the antioxidant and anti-inflammatory properties of its polyphenol and flavonoid contents. Polyphenols, such as caffeic acid, p-coumaric acid, and gallic acid, are some of the phenolic acids known to have antiobesity and antihyperlipidaemic properties. They could inhibit the gene expression of sterol regulatory element-binding transcription factor 1 and its target lipogenic enzyme, fatty acid synthase (FAS). Meanwhile, caffeic acid and quercetin in honey are also known to reduce body weight and fat mass. In addition, fructooligosaccharides in honey are also known to alter lipid metabolism by reducing FAS activity. The fructose and phenolic acids might contribute to the hypoglycaemic properties of honey through the phosphatidylinositol 3-kinase/protein kinase B insulin signalling pathway. Honey can increase the expression of Akt and decrease the expression of nuclear factor-kappa B. Quercetin, a component of honey, can improve vasodilation by enhancing nitric oxide production via endothelial nitric oxide synthase and stimulate calcium-activated potassium channels. In conclusion, honey can be used as a functional food or adjuvant therapy to prevent and manage metabolic syndrome.

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Honey and obesity-related dysfunctions: a summary on health benefits

Cited by 46 publications

References 101 publications

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

Honey Production Process

The Mechanism of Honey in Reversing Metabolic Syndrome

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