Homonymous Hemianopia and Vision Restoration Therapy

Frolov, Alexander A.; Feuerstein, Jeanne; Subramanian, Prem S.

doi:10.1016/j.ncl.2016.08.010

Cited by 23 publications

(28 citation statements)

References 38 publications

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“…The time course of functional changes suggests that they are produced by some neural plasticity with similar time course, such as synaptic short-term potentiation (STP) and subsequent synaptic long-term potentiation (LTP) of neural circuits (31,32). Although many studies have shown positive effects of rehabilitation for cortical blindness (3)(4)(5), training is expensive and takes a long time. Furthermore, it may be ineffective for some patients.…”

Section: Discussionmentioning

confidence: 99%

“…Visual information mediated via the primary visual cortex (V1) is required for conscious sight (1,2). When the V1 is damaged, the visual fields opposite to the damaged V1 are impaired, a condition known as cortical blindness (3)(4)(5). However, patients with cortical blindness have unconscious visual functions called blindsight (6,7), possibly through visual information obtained from the superior colliculus (SC), which in turn projects to the amygdala (8)(9)(10) and the higher visual cortex (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction

Shibuki

Wakui²,

Fujimura³

et al. 2020

Front. Neurol.

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When the primary visual cortex (V1) is damaged, cortical blindness results. However, visual information obtained from the superior colliculus (SC) or direct thalamic afferents to higher visual cortices produces unconscious visual functions called blindsight. Alarming visual stimuli suggesting the approach of a predator are known to trigger escape behaviors via visual information mediated by the SC and amygdala in small animals, and salient and dynamic visual stimuli also produce some conscious visual experience even in patients with blindsight. Fresh cortical blindness sometimes recovers spontaneously in patients with fresh cerebral damages, and recovery can be accelerated by early rehabilitation. However, the mechanisms underlying recovery are not well-known. We analyzed a patient with cortical blindness caused by an old cerebral infarction. After repeated presentation of alarming visual stimuli, the ability to detect visual stimuli in the impaired visual field showed behavioral short-term improvement (STI) within a few minutes. Repeated behavioral STI induction was followed by behavioral long-term improvement (LTI) lasting more than several days. After behavioral LTI, the patient partially recovered the ability to read letters presented in the impaired visual field. The behavioral STI experiment, which can be performed within 10 min, may serve as a clinical screening test for anticipating recovery from cortical blindness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction

Shibuki

Wakui²,

Fujimura³

et al. 2020

Front. Neurol.

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“…In NAION or RAO, spontaneous improvement of visual acuity is not unusual during the first weeks following the event, although significant improvement in the visual field seems to occur less commonly than improvement in acuity [28]. Moreover, approximately 60% of patients diagnosed with hemianopia can experience spontaneous improvement in the visual field, usually in the first 10 days after brain injury and decreasing progressively with every successive month, with less than 10% of patients recovering their full field [29]. Therefore, the recovery is variable, depending on the degree of neuronal death and the removal of the initial effects of the acute injury [13,30].…”

Section: Discussionmentioning

confidence: 99%

The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina

et al. 2020

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Nutritional supplementation with antioxidants and vitamins is widely recommended in the treatment of vascular disorders affecting the retina, although there is insufficient evidence on its effectiveness. The vitamin-like compound coenzyme Q10 (CoQ10) is a nutritional supplement of current interest to treat neurodegenerative diseases. Here, we report a retrospective clinical case series study of 48 patients diagnosed with retinal vascular diseases, including non-arteritic ischemic optic neuropathy (NAION), retinal artery occlusion (RAO), and homonymous hemianopia or quadrantanopia following stroke, treated with oral supplementation with CoQ10 (100 mg per day) and vitamins. Patient follow-up was performed using the Humphrey field analyzer and 30-2 testing algorithm to determine the visual field index (VFI) and progression rates. All treated patients showed positive VFI progression rates per year: +11.5 ± 15% for NAION patients (n = 18), +22 ± 17% for RAO patients (n = 7), +9.3 ± 10.5% for hemianopia/quadrantanopia patients (n = 10), and +11 ± 21% for patients with other conditions (n = 13). The interruption of CoQ10 supplementation in one patient resulted in a pronounced decrease of the VFI, which was partially recovered when treatment was restored. This study supports the role of CoQ10 as a nutritional therapeutic agent for vascular diseases affecting the retina. Owing to decreased VFI after interruption of CoQ10, its beneficial effects may be reversible.

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“…According with visual field impairment there are several lesions that can result in specific changes of visual field assessed by perimetry: unilateral defects as are centro-cecal scotoma that can result from retinal ganglion cells lesions (papillo-macular bundle area), or amblyopia that can result from interruption of the neural connections between the eye and the visual pathways from various causes including intraorbitar and prechiasmatic segment of the optic nerve (14,15). Hemianoptic, quadrianoptic and altitudinal defects that result from chiasmatic and post chismatic lesions of the visual pathways including occipital cortex (16). Visual integration disorders, associated with stroke, consist in failure of the visual cortical areas to process the visual information and can be classified as follow: alexia without agraphia associated with lesions of the corpus callosum (splenium) that connects the right occipital lobe and angular gyrus (patients in this situation are not able to read and failure to resolve their deficit by spectacle prescription) (17) ; visual agnosia that can be perceptive visual agnosia (the objects are not recognized and are associated with bilateral parieto-occipital lesions) and associative visual agnosia (where the visual perception of the objects can' t be associated with any visual experience or object memory) (18) ; Gertsmann syndrome represented by finger agnosia associated with rightleft disorientation, agraphia and acalculia that occur dominance hemisphere lesions (inferior parietal lobe -angular gyrus) (19) ; colour agnosia associated with temporal associative cortex lesions (20).…”

Section: Neurophysiologic Basis Of Vision and Associated Deficitsmentioning

confidence: 99%

Post-stroke visual rehabilitation - the impact on life quality of the stroke survival patients - a brief review

Bulboacă¹,

Bulboacă²,

Stănescu³

et al. 2019

Balneo

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Visual rehabilitation therapy (VRT) is one of the most important and difficult post stroke rehabilitation component that can considerably improve the quality of patient's life. There are also evidences that VRT contribute to a better motor recuperation, by offering a support for spatial and temporal orientation due to process of motor activity recuperation. Visual rehabilitation methods can be classified into the following groups: Visual Substitution Therapy, Visual Scanning Training (VST), Audio-Visual Scanning Training (AViST) and Vision Restoration Training (VRT). Even the evaluation of the results of training methods have an important subjective component, being assessed by various questionnaires, there are continues improving of these methods designed to achieve better results in post stroke rehabilitation therapy. Understanding the anatomical support and psysiological background of the visual process in brain networks, and also, the pathophysiology of visual function impairment after stroke, could be a good support for an personalized rehabilitation therapy adapted to each patient. This paper is aimed to emphasise the main methods of vision rehabilitation therapy in order to offer to the post stroke rehabilitation team an instrument for their day by day activities designed to improve the quality of life for stroke surviving patients.

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Homonymous Hemianopia and Vision Restoration Therapy

Cited by 23 publications

References 38 publications

Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction

Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction

The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina

Post-stroke visual rehabilitation - the impact on life quality of the stroke survival patients - a brief review

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