Homonymous hemi-macular atrophy of the ganglion cell-inner plexiform layer with preserved visual function

Lukewich, Mark K.; Schlenker, Matthew B.

doi:10.1016/j.jns.2020.117072

Cited by 8 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have described several cases of homonymous hemi‐atrophy of the GCIPL in non‐ON eyes associated with posterior visual pathway inflammatory injuries involving OR, lateral geniculate nucleus or visual cortex. 33 , 34 , 35 , 36 This relationship was observed not only in pwMS with homonymous hemianopia, but also in those with at least a certain degree of visual symptomatology. To further investigate this relationship and determine whether posterior visual pathway lesions showed good localizing features on retina atrophy, we also evaluated the correlation between homonymous hemi‐macular GCIPL thinning and OR lesions.…”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis

Lin,

Chien,

Kuchling

et al. 2023

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveRetrograde trans‐synaptic neuroaxonal degeneration is considered a key pathological factor of subclinical retinal neuroaxonal damage in multiple sclerosis (MS). We aim to evaluate the longitudinal association of optic radiation (OR) lesion activity with retinal neuroaxonal damage and its role in correlations between retinal and brain atrophy in people with clinically isolated syndrome and early MS (pweMS).MethodsEighty‐five pweMS were retrospectively screened from a prospective cohort (Berlin CIS cohort). Participants underwent 3T magnetic resonance imaging (MRI) for OR lesion volume and brain atrophy measurements and optical coherence tomography (OCT) for retinal layer thickness measurements. All pweMS were followed with serial OCT and MRI over a median follow‐up of 2.9 (interquartile range: 2.6–3.4) years. Eyes with a history of optic neuritis prior to study enrollment were excluded. Linear mixed models were used to analyze the association of retinal layer thinning with changes in OR lesion volume and brain atrophy.ResultsMacular ganglion cell‐inner plexiform layer (GCIPL) thinning was more pronounced in pweMS with OR lesion volume increase during follow‐up compared to those without (Difference: −0.82 μm [95% CI:‐1.49 to −0.15], p = 0.018). Furthermore, GCIPL thinning correlated with both OR lesion volume increase (β [95% CI] = −0.27 [−0.50 to −0.03], p = 0.028) and brain atrophy (β [95% CI] = 0.47 [0.25 to 0.70], p < 0.001). Correlations of GCIPL changes with brain atrophy did not differ between pweMS with or without OR lesion increase ( = 5.92e−7, p = 0.762).InterpretationFaster GCIPL thinning rate is associated with increased OR lesion load. Our results support the value of GCIPL as a sensitive biomarker reflecting both posterior visual pathway pathology and global brain neurodegeneration.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 82%

Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis

Lin,

Chien,

Kuchling

et al. 2023

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…The importance of OCT in localizing retrochiasmal visual field defects has been previously reported as the 24-2 visual field may be normal in both eyes. Lukewich et al [7] described 7 patients with homonymous OCT GCIPL hemi-macular atrophy related to demyelination or traumatic brain injury. Other pathologies may also produce such a change.…”

Section: Discussionmentioning

confidence: 99%

Monocular Visual Field Defect on Humphrey 24-2 SITA-Fast Testing Later Identified as a Highly Incongruous Homonymous Defect on Humphrey 30-2 SITA-Fast Testing

Micieli

2021

Case Rep Ophthalmol

Self Cite

View full text Add to dashboard Cite

Monocular visual field defects generally localize at or anterior to the optic chiasm, while homonymous hemianopias localize to the retrochiasmal visual pathway. Highly incongruous visual field defects may be difficult to identify on 24-2 Humphrey visual field testing, and this case demonstrates the value of optical coherence tomography (OCT) ganglion cell-inner plexiform layer (GCIPL) in rapidly localizing the lesion. A 54-year-old woman was found on routine examination to have an isolated superonasal quadrant visual field defect respecting the vertical meridian in the left eye only on Humphrey 24-2 SITA-Fast testing. She had a remote history of significant head trauma. Visual acuity, anterior segment, and fundus examination were normal. OCT revealed a bow-tie atrophy of the retinal nerve fiber layer in the right eye (OD), and binocular homonymous hemi-macular atrophy of OCT GCIPL, confirming the localization was the left retrochiasmal visual pathway. A repeat Humphrey 30-2 SITA-Fast visual field demonstrated that the visual field defect was also present in the OD in a highly incongruous manner. Magnetic resonance imaging of the brain with contrast showed mild atrophy of the left optic tract. This case demonstrates that highly incongruous visual field defects may be difficult to identify on Humphrey 24-2 SITA-Fast visual fields, and OCT GCIPL serves as a rapid way to localize the lesion. More detailed visual field testing including 30-2 programs should be considered in these cases.

show abstract

“…In retrochiasmal lesions, homonymous hemiatrophy seen in the mGCIPL may be apparent before visual field deficits are detected 34 and may assist in the early detection of these lesions 38 . mGCIPL thinning may also persist after the visual field deficits have resolved, such as in cases of remote traumatic brain injuries 39 …”

Section: Advances In Oct For Neuro‐ophthalmologymentioning

confidence: 99%

Recent advances in the use of optical coherence tomography in neuro‐ophthalmology: A review

Ge,

Teo,

Loo

2024

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Optical coherence tomography (OCT) is an in vivo imaging modality that provides non‐invasive, high resolution and fast cross‐sectional images of the optic nerve head, retina and choroid. OCT angiography (OCTA) is an emerging tool. It is a non‐invasive, dye‐free imaging approach of visualising the microvasculature of the retina and choroid by employing motion contrast imaging for blood flow detection and is gradually receiving attention for its potential roles in various neuro‐ophthalmic and retinal conditions. We will review the clinical utility of the OCT in the management of various common neuro‐ophthalmic and neurological disorders. We also review some of the OCTA research findings in these conditions. Finally, we will discuss the limitations of OCT as well as introduce other emerging technologies.

show abstract

Homonymous hemi-macular atrophy of the ganglion cell-inner plexiform layer with preserved visual function

Cited by 8 publications

References 17 publications

Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis

Interactions of optic radiation lesions with retinal and brain atrophy in early multiple sclerosis

Monocular Visual Field Defect on Humphrey 24-2 SITA-Fast Testing Later Identified as a Highly Incongruous Homonymous Defect on Humphrey 30-2 SITA-Fast Testing

Recent advances in the use of optical coherence tomography in neuro‐ophthalmology: A review

Contact Info

Product

Resources

About