Proc Natl Acad Sci USA volume 115, issue 39, PE9211-E9219 2018 DOI: 10.1073/pnas.1810229115 View Full Text
|
|
Share
Lauren C. Aguado, Tristan X. Jordan, Emily Hsieh, Daniel Blanco-Melo, John Heard, Maryline Panis, Marco Vignuzzi, Benjamin R. tenOever

Abstract: RNA interference (RNAi) is the major antiviral defense mechanism of plants and invertebrates, rendering the capacity to evade it a defining factor in shaping the viral landscape. Here we sought to determine whether different virus replication strategies provided any inherent capacity to evade RNAi in the absence of an antagonist. Through the exploitation of host microRNAs, we recreated an RNAi-like environment in vertebrates and directly compared the capacity of positive- and negative-stranded RNA viruses to c…

expand abstract
Filters

Filter received citations by the textual context, citing paper title, authors, etc.

Citation Types

0
8
0

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship beta

0
0