Homogeneous Electrochemiluminescence in the Sensors Game: What Have We Learned from Past Experiments?

Nasrollahpour, Hassan; Khalilzadeh, Balal; Naseri, Alireza; Chia, Chin Hua

doi:10.1021/acs.analchem.1c03909

Cited by 42 publications

(15 citation statements)

References 148 publications

(220 reference statements)

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“…Biosensors are diagnostic tools developed in response to challenges with conventional methods that have some vital gaps and shortages to use in point-of-care settings. 97 Depending on the utilized transducing strategy, various biosensors have been developed over the past decades, including fluorescence, 98,99 chemiluminescence, 100,101 ECL, 102,103 plasmonic, 104,105 scattering, 106,107 and EC assays. 108,109 All these biosensor formats are classified into four major classes regarding the bioreceptor agents and biomarker molecules: (i) immunosensors;…”

Section: Biosensing Strategiesmentioning

confidence: 99%

Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers

Nasrollahpour

Khalilzadeh

Hasanzadeh

et al. 2022

Medicinal Research Reviews

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Breast cancer is categorized as the most widespread cancer type among women globally. On-time diagnosis can decrease the mortality rate by making the right decision in the therapy procedure. These features lead to a reduction in medication time and socioeconomic burden. The current review article provides a comprehensive assessment for breast cancer diagnosis using nanomaterials and related technologies. Growing use of the nano/biotechnology domain in terms of electrochemical nanobiosensor designing was discussed in detail. In this regard, recent advances in nanomaterial applied for amplified biosensing methodologies were assessed for breast cancer diagnosis by focusing on the advantages and disadvantages of these approaches. We also monitored designing methods, advantages, and the necessity of suitable (nano) materials from a statistical standpoint.The main objective of this review is to classify the applicable biosensors based on breast cancer biomarkers.With numerous nano-sized platforms published for breast cancer diagnosis, this review tried to collect the most suitable methodologies for detecting biomarkers and certain breast cancer cell types.

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Section: Biosensing Strategiesmentioning

confidence: 99%

Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers

Nasrollahpour

Khalilzadeh

Hasanzadeh

et al. 2022

Medicinal Research Reviews

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“…Electrochemiluminescence (ECL), a light-emitting process triggered by the redox reaction of an excited luminophore, − has gotten tremendous attention in potential applications of biological and environmental sensing owing to its merits of simple instrumentation, high sensitivity, and wide dynamic detection range. − In classical luminol ECL systems, luminol is used as an ideal luminophore due to its high emission efficiency, low oxidation potential, and nontoxicity . In practical ECL applications, to enhance the performance of the relevant ECL systems, a coreactant is usually required, and then dissolved O 2 (DO) is often selected due to its excellent stability and ecofriendly characteristics .…”

Section: Introductionmentioning

confidence: 99%

Integration of High-Entropy Oxide with Nitrogen-Doped Graphene for the Ultrasensitive Electrochemiluminescence Detection of Trolox and Dopamine

Bushira

Wang

Hussain

et al. 2023

ACS Appl. Nano Mater.

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Developing luminol-dissolved O2 (luminol-DO) electrochemiluminescence (ECL) systems with high performance as well as excellent stability to enhance the low ECL efficiency of DO is highly desired for real applications. Here, we prepared a composite of high-entropy oxide (HEO) and nitrogen-doped graphene (HEO/N-G), with well-defined abundant oxygen vacancies, and used it for performance-enhanced luminol-DO ECL sensing applications. Benefiting from its unique electronic structure, reactive oxygen species could be efficiently produced, followed by reaction with electrochemically generated luminol anion radicals to generate a much-enhanced signal of the resulting ECL system. The developed HEO/N-G-based luminol-DO ECL system was further successfully exploited for the ultrasensitive detection of Trolox and dopamine in the linear ranges of 1 nM to 25 μM and 100 pM to 10 nM, with detection limits of 1.0 and 0.00093 nM, respectively. The underlying ECL mechanism of the HEO/N-G luminol-DO ECL system was also discussed.

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“…There are numerous reviews and features for ECL biosensors in recent years on ECL mechanisms, 6,7 ECL nanomaterials, [8][9][10][11] biosensing strategies, [12][13][14][15][16][17] and ECL analytical applications. 18,19 This Feature Article provides a didactic examination of the concepts and approaches related to new biological recognition elements, new ECL reagents and materials, and emerging construction of biointerfacial strategies in ECL biosensors for biomarkers, mainly contributed by our group and partly done by other groups recently, as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Recent advances and challenges in developing electrochemiluminescence biosensors for health analysis

Wei

Zhang

2023

Chem. Commun.

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Homogeneous Electrochemiluminescence in the Sensors Game: What Have We Learned from Past Experiments?

Cited by 42 publications

References 148 publications

Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers

Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers

Integration of High-Entropy Oxide with Nitrogen-Doped Graphene for the Ultrasensitive Electrochemiluminescence Detection of Trolox and Dopamine

Recent advances and challenges in developing electrochemiluminescence biosensors for health analysis

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