Homocysteine level is positively and independently associated with serum creatinine and urea nitrogen levels in old male patients with hypertension

Qian-hong, Yang; Lu, Yaobin; Deng, Yuxiang; Xu, Jiayi; Zhang, Xi

doi:10.1038/s41598-020-75073-x

Cited by 15 publications

(7 citation statements)

References 43 publications

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“…Analysis of the effect of clinicopathological and laboratory parameters on the change in homocysteine level revealed the previously known relationships that hyperhomocysteinemia is associated with elevated serum lipids [27,47], white blood cell [30,48] and platelet counts [49,50], liver enzymes [51,52], reduced renal function [29,53,54], cardiovascular diseases [55], type 2 diabetes mellitus [56,57], and male sex [14]. To our knowledge, the observations that serum homocysteine level is higher in the right-sided colorectal tumors and the normalization of serum total protein level entails a constant homocysteine level, were never described previously.…”

Section: Discussionmentioning

confidence: 94%

Longitudinal Analysis of 1α,25-dihidroxyvitamin D3 and Homocysteine Changes in Colorectal Cancer

Mühl

Herold

et al. 2022

Cancers

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Background: 1α,25-dihydroxycholecalciferol (1,25(OH)2D3) and homocysteine are known to play a role in the pathophysiology of colorectal cancer (CRC). In health, the two changes are inversely proportional to each other, but little is known about their combined effect in CRC. Methods: The serum 1,25(OH)2D3 and the homocysteine levels of eighty-six CRC patients were measured, who were enrolled into four cohorts based on the presence of metastases (Adj vs. Met) and vitamin D3 supplementation (ND vs. D). Results: 1,25(OH)2D3 was constant (Adj-ND), increased significantly (Adj-D, p = 0.0261), decreased (Met-ND), or returned close to the baseline after an initial increase (Met-D). The longitudinal increase in 1,25(OH)2D3 (HR: 0.9130, p = 0.0111) positively affected the overall survival in non-metastatic CRC, however, this effect was cancelled out in those with metastasis (p = 0.0107). The increase in homocysteine negatively affected both the overall (HR: 1.0940, p = 0.0067) and the progression-free survival (HR: 1.0845, p = 0.0073). Lower 1,25(OH)2D3 and/or higher homocysteine level was characteristic for patients with higher serum lipids, albumin, total protein, white blood cell and platelet count, male sex, and right-sided tumors. No statistically justifiable connection was found between the target variables. Conclusions: A measurement-based titration of vitamin D3 supplementation and better management of comorbidities are recommended for CRC.

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Section: Discussionmentioning

confidence: 94%

Longitudinal Analysis of 1α,25-dihidroxyvitamin D3 and Homocysteine Changes in Colorectal Cancer

Mühl

Herold

et al. 2022

Cancers

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“…In the present study, we found that Cr was a common risk factor, which was positively correlated with Hcy concentration in all the groups. This positive relationship between Cr and Hcy was present in HHcy patients with or without hypertension (31,32). Another evidence is that Hcy level could be increased in a dose-response effect by Guanidinoacetic acid (GAA), an intermediate in the (34).…”

Section: Discussionmentioning

confidence: 95%

Systemic risk factors correlated with hyperhomocysteinemia for specific MTHFR C677T genotypes and sex in the Chinese population

Xiang

Yan

et al. 2020

Ann Transl Med

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Background: Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine (Hcy) metabolism. A common C677T mutation in the MTHFR gene results in decreased enzyme activity, which contributes to hyperhomocysteinemia (HHcy). Previous studies have shown that HHcy was correlated with various systemic diseases, such as cardiovascular disease, stroke, cancer, renal failure and so on.However, we hypothesized that HHcy in different genotype and sex groups may have different risk factors, which would lead to various pathologic states. Therefore, the aim of this study was to explore systemic information that are correlated with HHcy for specific MTHFR C677T genotypes and sex, which might be useful for predicting and preventing systemic diseases. Methods: This cross-sectional study was performed through November 2017 to July 2019. A total of 4,534 adults aged 20-75 y were selected for this study. All the participants underwent a physical examination, blood tests and MTHFRC677T genotyping. Multivariable linear regression was performed to explore the risk factors for HHcy for each sex and genotype. Results:The average of Hcy level is higher in the TT genotype than CC and CT genotypes (P=0.000).Multiple linear regression analysis identified the common protective factors (folate and Vit B12) and risk factor (Cr) for HHcy. Besides that, each group has its specific risk factors-female-CT (age, SBP, and Hb), female-TT (SBP and AST); male-CC (age, AST and Hb), male-CT (age and AST) and male-TT (SBP, AST, and Hb).Conclusions: HHcy was associated with different risk factors for each specific sex and genotype. These risk factors might be useful for predicting and preventing systemic diseases.

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“…[29] Studies on elderly patients with hypertension in China reported that HHcy can predict a decline of kidney function. [30] Furthermore, CVD may also occur after CKD through various mechanisms such as increased Hcy concentration, oxidative stress, and endothelial dysfunction. [31] However, results on the effect of HHcy on death in advanced CKD patients, are inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Association between homocysteinemia and mortality in CKD: A propensity-score matched analysis using NHANES-National Death Index

et al. 2022

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Hyperhomocysteinemia (HHcy) is considered a risk factor for cardiovascular disease (CVD), including chronic kidney disease (CKD). In this study, we investigated the association between levels of serum homocysteine (Hcy) and mortality, inferred from the presence of CKD. Our study included data of 9895 participants from the 1999 to 2016 National Health and Nutrition Examination Surveys (NHANES). Multivariable-adjusted Cox proportional hazard models using propensity-score, were used to examine doseresponse associations between Hcy level and mortality. A total of 9895 participants, 1025 (10.3%) participants were diagnosed with CKD. In a multivariate Cox regression analysis including all participants, Hcy level was significantly associated with all-cause mortality in the nonCKD group, compared to the 1 st quartile in the fully adjusted model (2 nd quartile: hazard ratio (HR) 1.75, 95% confidence interval (CI) 1.348-2.274, P < .001; 3 rd quartile: HR 2.22, 95% CI 1.726-2.855, P < .001; 4 th quartile: HR 3.77, 95% CI 2.952-4.830, P < .001). However, this finding was not observed in the CKD group. The observed pattern was similar after propensity score matching. In the nonCKD group, overall mortality increased in proportion to Hcy concentration (2 nd quartile:

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Homocysteine level is positively and independently associated with serum creatinine and urea nitrogen levels in old male patients with hypertension

Cited by 15 publications

References 43 publications

Longitudinal Analysis of 1α,25-dihidroxyvitamin D3 and Homocysteine Changes in Colorectal Cancer

Longitudinal Analysis of 1α,25-dihidroxyvitamin D3 and Homocysteine Changes in Colorectal Cancer

Systemic risk factors correlated with hyperhomocysteinemia for specific MTHFR C677T genotypes and sex in the Chinese population

Association between homocysteinemia and mortality in CKD: A propensity-score matched analysis using NHANES-National Death Index

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