Homocysteine is Associated with Exaggerated Morning Blood Pressure Surge in Patients with Acute Ischemic Stroke

Xie, Junchao; Lin, Yingying; Lu, Xiaohui; Zhao, Yichen; Ma, Xiaoxiao; Yu, Jia; Liu, Xueyuan; Zhao, Yanxin

doi:10.1016/j.jstrokecerebrovasdis.2018.05.032

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…Specific targets to increase the availability of methyl donor include acceleration of the conversion from homocysteine to methionine. Abnormally high levels of homocysteine have been reported to be a significant risk factor for the development of a wide range of diseases such as in cerebrovascular diseases [ 241 , 242 , 243 , 244 ], various CVDs [ 245 , 246 , 247 , 248 , 249 ], cognitive impairment including Alzheimer’s disease [ 250 , 251 , 252 ], fractures [ 253 , 254 , 255 ], and mortality [ 256 ]. Deficiencies of vitamin B12, folate, or vitamin B6 seem to play an important role in the occurrence of hyperhomocysteinemia, because they are essential for homocysteine metabolism ( Figure 2 ), and treatment with B-vitamin supplementation (B6, B12, and folate) has been demonstrated to effectively lower homocysteine levels [ 257 , 258 , 259 , 260 , 261 ].…”

Section: Nutrients and Their Metabolites And Enzymes Related To Dnmentioning

confidence: 99%

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Soda

2018

IJMS

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Recent investigations have revealed that changes in DNA methylation status play an important role in aging-associated pathologies and lifespan. The methylation of DNA is regulated by DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) in the presence of S-adenosylmethionine (SAM), which serves as a methyl group donor. Increased availability of SAM enhances DNMT activity, while its metabolites, S-adenosyl-l-homocysteine (SAH) and decarboxylated S-adenosylmethionine (dcSAM), act to inhibit DNMT activity. SAH, which is converted from SAM by adding a methyl group to cytosine residues in DNA, is an intermediate precursor of homocysteine. dcSAM, converted from SAM by the enzymatic activity of adenosylmethionine decarboxylase, provides an aminopropyl group to synthesize the polyamines spermine and spermidine. Increased homocysteine levels are a significant risk factor for the development of a wide range of conditions, including cardiovascular diseases. However, successful homocysteine-lowering treatment by vitamins (B6, B12, and folate) failed to improve these conditions. Long-term increased polyamine intake elevated blood spermine levels and inhibited aging-associated pathologies in mice and humans. Spermine reversed changes (increased dcSAM, decreased DNMT activity, aberrant DNA methylation, and proinflammatory status) induced by the inhibition of ornithine decarboxylase. The relation between polyamine metabolism, one-carbon metabolism, DNA methylation, and the biological mechanism of spermine-induced lifespan extension is discussed.

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Section: Nutrients and Their Metabolites And Enzymes Related To Dnmentioning

confidence: 99%

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Soda

2018

IJMS

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“…Homocysteine (Hcy) has been involved in the pathogenesis of hypertension by producing endothelial injury [3,4], increasing oxidative stress [5], stimulating the proliferation of vascular smooth muscle cells (VSMCs) [6], and altering the elastic properties of the vascular wall [7]. Elevated Hcy and its related genetic variants have been associated with blood pressure [8][9][10][11][12], hypertension [13][14][15], and related vascular complications, e.g., atherosclerosis [16,17], coronary heart disease [18,19], and stroke [20,21], in humans. In the process of Hcy-induced hypertension, the endothelial injury resulting from Hcy promotes platelet consumption and adherence which stimulates the proliferation of VSMCs through releasing mitogenic factors [22], thereby contributing to atherosclerosis, arterial stiffness, and high blood pressure [23,24] Furthermore, platelet activation has been associated with Hcy [25] but also hypertension [26] in population studies.…”

Section: Introductionmentioning

confidence: 99%

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Zhang

Shi

et al. 2020

International Journal of Hypertension

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Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. e association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P � 0.004) in participants with low platelet count (<210 × 10 9 /L) than in those with high platelet count (≥210 × 10 9 /L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P � 0.0001), and the interaction was significant (β = − 0.021, P < 0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. e association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. ese results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation.

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“…Furthermore, they also noted that in order to improve the cure rate, reduce the disability rate and improve the prognosis of stroke patients, the complications should be actively prevented and treated. A previous study revealed that there are certain synergic factors in the process of progressive cerebral infarction caused by hypertension, such as high homocysteine and diabetes (7). The incidence of hypertension is significantly higher in diabetic patients with cerebral infarction than in patients with cerebral infarction alone (8).…”

Section: Discussionmentioning

confidence: 98%

Application of Concomitant Disease Scoring in Acute Cerebral Infarction

Zhao¹,

Li²,

Liu³

et al. 2020

Iran Red Crescent Med J

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Background: Acute cerebral infarction (ACI) is a common cerebrovascular disease that seriously endangers human health. It is very important to carry out disease assessments to rescue patients who may suffer from preventable death. Objectives: This study aimed to explore the predictive value of concomitant disease scoring for the prognosis of patients with ACI. Methods: This is a respective observational study. A total of 399 patients with ACI from the Affiliated Hospital of North China University of Science and Technology, who met the inclusion criteria, were enrolled in the present study. The concomitant disease score was assessed within 24 hours after admission, and the risk degree of death was analyzed. Then, the goodness of fit test and validity analysis were carried out, and the best survival/death cutoff value was determined. Results: The area under the receiver operating characteristic (ROC) curve for the concomitant disease score was 0.700, the distinctiveness was relatively good, and the prediction cutoff value was 10 points. Furthermore, the mortality rate of patients with a higher score was significantly higher compared to patients with a lower score. Conclusions: The concomitant disease score has good predictive value for the prognosis of ACI patients, and is an ideal system for evaluating the condition of cerebral infarction.

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Homocysteine is Associated with Exaggerated Morning Blood Pressure Surge in Patients with Acute Ischemic Stroke

Cited by 4 publications

References 31 publications

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients

Application of Concomitant Disease Scoring in Acute Cerebral Infarction

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