Homocysteine as a prognostic marker of atrial remodeling and clinical picture in patients with paroxysmal and persistent forms of atrial fibrillation

Snezhitsky, V. A.; Yatskevich, Ekaterina Sergeewna; Дорошенко, Е. М.; Smirnov, V. Yu.; Dolgoshey, T. S.; Rubinsky, A. Yu.

doi:10.18821/0023-2149-2016-94-1-16-22

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Гипергомоцистеинемия ассоциирована с увеличением риска прогрессирования ФП. Уровень гомоцистеина более 11 мкмоль/л -предиктор частого рецидивирования аритмии у пациентов с ФП [16].…”

Section: н в буквальная л в якубова в а снежицкий гродненский государ...unclassified

Risk Stratification of Atrial Fibrillation Progression in Patients With Arterial Hypertension and the Ways of Secondary Prevention

Bukvalnaya¹,

Yakubava²,

Snezhitskiy³

2023

Journal GrGMU

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Progression of atrial fibrillation (AF) is a process of steady development of arrhythmia from short paroxysms to the permanent form. Arterial hypertension (AH) is the most common cause of AF. The aim of this review is to highlight the role of possible predictors of AF progression in hypertensive patients. The role of general risk factors in the maintenance of arrhythmia, the significance of high blood pressure and its individual characteristics in the progression of AF are analyzed. Echocardiographic predictors of arrhythmia recurrence and the transition of AF to a permanent form in hypertension are described. Various existing scales for assessing the risk of AF progression are presented. The ways of secondary prevention of arrhythmia in AH are considered.

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Section: н в буквальная л в якубова в а снежицкий гродненский государ...unclassified

Risk Stratification of Atrial Fibrillation Progression in Patients With Arterial Hypertension and the Ways of Secondary Prevention

Bukvalnaya¹,

Yakubava²,

Snezhitskiy³

2023

Journal GrGMU

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“…However, only several studies have addressed the association between Hcy and AF risk ( Schnabel et al, 2010 ). Although these studies have reported an association of elevated plasma Hcy levels with increased AF risk, it is difficult to distinguish causal association from spurious association in observational studies ( Snezhitsky et al, 2016 ; Wei et al, 2017 ; Yao et al, 2017a ). Further studies are warranted to clarify the causative relationship between Hcy and AF.…”

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confidence: 99%

Appraising the Causal Association of Plasma Homocysteine Levels With Atrial Fibrillation Risk: A Two-Sample Mendelian Randomization Study

Chen

Yang

et al. 2021

Front. Genet.

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BackgroundAlthough several observational studies have suggested an association of elevated plasma homocysteine (Hcy) levels with increased risk of atrial fibrillation (AF), it remains unclear whether this association reflects causality. In this study, we aimed to investigate the causal association of plasma Hcy levels with AF risk.MethodsA two-sample Mendelian randomization (MR) study was designed to investigate the causal association of Hcy with AF. Summary data on association of single nucleotide polymorphisms (SNPs) with Hcy were extracted from the hitherto largest genome-wide association study (GWAS) with up to 44,147 individuals, and statistics data on association of SNPs with AF were obtained from another recently published GWAS with up to 1,030,836 individuals. SNPs were selected at a genome-wide significance threshold (p < 5 × 10–8). Fixed-effect inverse variance weighting (IVW) method was used to calculate the causal estimate. Other statistical methods and leave-one-out analysis were applied in the follow-up sensitivity analyses. MR-Egger intercept test was conducted to detect the potential directional pleiotropy.ResultsIn total, nine SNPs were identified as valid instrumental variables in our two-sample MR analysis. Fixed-effect IVW analysis indicated no evidence of causal association of genetically predicted Hcy with AF. The odds ratio (OR) and 95% confidence interval (CI) of AF per standard deviation (SD) increase in Hcy were 1.077 (0.993, 1.168), p = 0.075. Similar results were observed in the sensitivity analyses. MR-Egger intercept test suggested no evidence of potential horizonal pleiotropy.ConclusionsThis two-sample MR analysis found no evidence to support causal association of Hcy with AF.

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Homocysteine and atrial fibrillation: novel evidences and insights

Іванов

Smereka²,

Rasputin³

et al. 2022

Monaldi Arch Chest Dis

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Atrial fibrillation (AF) is one of the most prevalent rhythm disorders worldwide, with around 37.574 million cases around the globe (0.51 % global population). Different studies showed a high informative value of different biomarkers, including such related to the systemic inflammation, biomechanical stress and fibrosis. In this review article we aimed to study only the relation of homocysteine to the AF development. Homocysteine is a sulfur-containing amino acid, that is produced in the process of methionine metabolism. Which is a non-canonical amino acid, that is derived from the food proteins. From the scientific point of view there is a relation between hyperhomocysteinemia and myocardial fibrosis, but these mechanisms are complicated and not sufficiently studied. Homocysteine regulates activity of the ion channels through their redox state. Elevated homocysteine level can condition electrical remodeling of the cardiomyocytes through the increase of sodium current and change in the function of rapid sodium channels, increase of inwards potassium current and decrease in amount of rapid potassium channels. High homocysteine concentration also leads to the shortening of the action potential, loss of the rate adaptation of the action potential and persistent circulation of the re-entry waves. In a series of experimental studies on mice there was an association found between the homocysteine level and activity of vascular inflammation. Elevation of homocysteine level is an independent factor of the thromboembolic events and AF relapses. Population studies showed, that homocysteine is an independent risk factor for AF. So, homocysteine is an interesting target for up-stream therapy.

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Homocysteine as a prognostic marker of atrial remodeling and clinical picture in patients with paroxysmal and persistent forms of atrial fibrillation

Cited by 5 publications

References 10 publications

Risk Stratification of Atrial Fibrillation Progression in Patients With Arterial Hypertension and the Ways of Secondary Prevention

Risk Stratification of Atrial Fibrillation Progression in Patients With Arterial Hypertension and the Ways of Secondary Prevention

Appraising the Causal Association of Plasma Homocysteine Levels With Atrial Fibrillation Risk: A Two-Sample Mendelian Randomization Study

Homocysteine and atrial fibrillation: novel evidences and insights

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