Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis

Salagre, Estela; Vizuete, Adriana Fernanda Kuckartz; Leite, Marina Concli; Brownstein, DJ; McGuinness, Amelia J; Jacka, Felice N.; Dodd, Seetal; Stubbs, Brendon; Köhler, CA; Vieta, Eduard; Carvalho, AF; Berk, Michael; Fernandes, Brisa S.

doi:10.1016/j.eurpsy.2017.02.482

Cited by 37 publications

(24 citation statements)

References 145 publications

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“…In this study, BD patients had significantly higher prevalence of HHcy and greater plasma Hcy levels, which was consistent with the majority of previous studies assessing HHcy (Ezzaher et al, 2011;Permoda-Osip et al, 2013) and detecting Hcy levels in acute bipolar depressive episode (Chiarani et al, 2013;Salagre et al, 2017) and in remission (Chiarani et al, 2013;Dittmann et al, 2007) of BD. Furthermore, we found sex differences in HHcy rates and Hcy concentrations in BD patients, which was in agreement with previous studies showing elevated Hcy levels and HHcy rates in male patients compared with both their corresponding healthy controls and female patients; however, no significant difference was noted between BD women and female controls (Levine, Sela, Osher, & Belmaker, 2005;Osher et al, 2004;Permoda-Osip et al, 2013;Permoda-Osip et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…Peripheral homocysteine (Hcy) has been considered as a potential biomarker for bipolar disorder (BD; Ghanizadeh, Singh, Berk, & Torabi‐Nami, ; Salagre et al, ). BD patients with hyperhomocysteinemia (HHcy) usually show abnormally high levels of Hcy in the blood (Chiarani et al, ; Dittmann et al, ; Osher, Bersudsky, Silver, Sela, & Belmaker, ; Osher, Sela, Levine, & Belmaker, ), which could increase the risk of cardiovascular disease (Chiarani et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder

Lin

Huang

et al. 2020

Human Psychopharmacology

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Objective Sex differences in bipolar disorder are well recognized but little attention has been paid to sex differences in homocysteine or hyperhomocysteinemia in bipolar patients. This study compared gender differences in homocysteine levels and rates of hyperhomocysteinemia in Chinese inpatients with bipolar disorder. Methods A total of 198 BD patients and 84 healthy controls were enrolled. The Young Mania Rating Scale, Hamilton Depression Rating Scale, and the Clinical Global Impressions–Severity scale were used to assess the affective symptomatology. Fasting plasma Hcy levels were measured by high‐performance liquid chromatography. Results Men had higher homocysteine levels than women and the prevalence of hyperhomocysteinemia in male patients was approximately twice that in female patients. Logistic regression analyses showed that HHcy was associated with less frequent use of valproate in males and being overweight in females. Further correlation analysis and multivariate regression analysis demonstrated that Hcy levels were inversely correlated with valproate treatment in men and positively associated with overweight in women. Conclusions In bipolar patients, there are significant differences between sexes in the levels of homocysteine and prevalence of hyperhomocysteinemia. This appears to be associated with lower prevalence of valproate prescribing in men and with being overweight in women.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder

Lin

Huang

et al. 2020

Human Psychopharmacology

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“…The defects in cobalamin metabolism may involve a deficiency of homocysteine metabolism that lead to higher circulating homocysteine . A high plasma homocysteine has been proposed to relate to cardiovascular disease, multiple sclerosis and depression as well as psoriasis . A deficient gene function for iron transporter might be related to a reduced iron uptake.…”

Section: Discussionmentioning

confidence: 99%

Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients

Chen¹,

Tseng

et al. 2018

Experimental Dermatology

121

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Objectives The intestinal microbiota has been known to involve in obesity and host immune response. We aimed to investigate the intestinal microbiota and potential genetic function in relation to clinical presentation in psoriasis patients. Methods Faecal microbiota and predicted genetic function inferred from high‐throughput 16S ribosomal RNA sequencing were analysed between psoriasis (n = 32) and age‐, gender‐ and body mass index (BMI)‐matched non‐psoriasis subjects (n = 64), from a referral medical centre. The correlation between altered microbiota and disease activity, arthritis and systemic anti‐psoriatic drugs was also investigated. Results We observed a distinct faecal microbial community structure in psoriasis patients, with an increased abundance of phylum Firmicutes and decreased abundance of phylum Bacteroidetes, across different subgroup of subjects. Ruminococcus and Megasphaera, of the phylum Firmicutes, were the top‐two genera of discriminant abundance in psoriasis. A number of functional genes and metabolic pathways involving bacterial chemotaxis and carbohydrate transport were predicted over‐represented, whereas genes related to cobalamin and iron transport were predicted under‐represented in faecal microbiota of psoriasis patients. Conclusions The distinct faecal microbial composition in psoriasis might be associated with altered transport of carbohydrate, cobalamin and iron, as well as chemotaxis.

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“…41 A recent meta-analysis has concluded that serum homocysteine levels are elevated in patients with BD even during the euthymic state. 42 These findings suggest that homocysteine is both a trait and state biomarker for patients with BD. In the studies of elderly general population, the serum levels of homocysteine over 11 umol/L were found to be associated with the increased risk of dementia and atrophy of medial temporal lobe.…”

Section: Discussionmentioning

confidence: 90%

Homocysteine, rather than age of onset, is a better predictor for cognitive function in older adults with bipolar disorder

Chen

Liu

et al. 2019

Int J Geriat Psychiatry

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Objectives The association between older‐age bipolar disorder and cognitive impairments may be mediated by vascular burden. The aim of the study was to examine the difference of cognitive function between older people with late‐onset bipolar disorder (LOBD) and early‐onset bipolar disorder (EOBD) by considering rigorous vascular risk burden evaluation, comprehensive cognitive tests, and relevant biochemistry data. Methods We recruited 95 outpatients aged over 55 with a DSM‐IV‐TR diagnosis of bipolar I disorder. Fifty had LOBD, defined by age of onset after 40. Cognitive function was evaluated through a battery of tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility. Vascular risk assessments included individual disorders, 10‐year Framingham cardiovascular risk scores, and serum levels of homocysteine, vitamin B12, folate, and triiodothyronine. Results No differences were observed between LOBD and EOBD on any cognitive test after adjusting for potential confounders. In addition to age and educational years, multiple linear regression analyses indicated significantly negative associations between serum homocysteine levels and cognitive performances in attention, psychomotor speed, verbal memory, and executive function. Conclusions Among older people with bipolar disorder, LOBD is not associated with more cognitive dysfunction in this study. However, higher serum homocysteine levels were significantly associated with worse cognitive performance in this particular group. Clinicians therefore have to pay attention to the cognitive function in older bipolar patients with higher levels of homocysteine.

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Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis

Cited by 37 publications

References 145 publications

Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder

Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder

Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients

Homocysteine, rather than age of onset, is a better predictor for cognitive function in older adults with bipolar disorder

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