Homocysteine and lipid peroxidation in haemodialysis: role of folinic acid and vitamin E

Bayés, Beatriz; Pastor, M.C.; Bonal, Jordi; Juncà, Jordi; Romero, R.

doi:10.1093/ndt/16.11.2172

Cited by 46 publications

(28 citation statements)

References 29 publications

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“…Although Brude et al [19] found a negative association between tHcy and ␤ -carotene intake in male smokers, no correlation was detected with either serum ␤ -carotene or serum vitamin E. Moreover, in the study by Mansoor et al [22] , the negative relationship of tHcy with serum ␤ -carotene as depicted by univariate linear regression analysis could not be confirmed in the evaluation by multivariate models. Furthermore, supplementing vitamin E among hemodialysis patients and triathletes [23,25] as well as in an animal study among gerbils [24] did not result in any change in tHcy.…”

Section: Discussionmentioning

confidence: 80%

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Effect of Antioxidant Vitamins on the Plasma Homocysteine Level in a Free-Living Elderly Population

Breilmann

Pons-Kühnemann²,

Brunner³

et al. 2010

Ann Nutr Metab

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Background: The factors influencing total plasma homocysteine levels (tHcy) are of special interest in the attempt to reduce cardiovascular risk. Aim: This investigation aimed to assess the independent effects of antioxidant vitamins on tHcy in elderly people. Methods: Our cross-sectional analysis included data of 184 subjects (≧60 years) from the longitudinal study in an aging population in Giessen (GISELA), Germany. We examined the effects of plasma levels, intake and supplementation of vitamin C, vitamin E, and β-carotene on tHcy. Results: The mean tHcy was within the normal range in this population. Serum folate, the estimated glomerular filtration rate (eGFR), and plasma vitamin C showed a negative association with tHcy in simple regression analysis. In a subsequent multiple regression analysis, eGFR, serum folate, and plasma vitamin C were the relevant independent predictors of tHcy. Intake and supplementation of vitamin C, as well as plasma levels, intake and supplementation of vitamin E, and β-carotene were not associated with tHcy. Conclusion: Vitamin C may be an independent predictor of tHcy in free-living elderly people and, therefore, should be considered in attempts to reduce tHcy.

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Section: Discussionmentioning

confidence: 80%

“…Four studies showed a negative correlation between tHcy and plasma levels or the intake of ␤ -carotene and vitamin C [19][20][21][22] , while several other trials failed to show an association between tHcy and plasma or serum levels or the intake of antioxidant vitamins [23][24][25][26] .…”

mentioning

confidence: 99%

Effect of Antioxidant Vitamins on the Plasma Homocysteine Level in a Free-Living Elderly Population

Breilmann

Pons-Kühnemann²,

Brunner³

et al. 2010

Ann Nutr Metab

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“…In the nephrological fields, many studies employ LOOH to evaluate oxidative stress in end-stage renal failure, uremia and hemodialysis (HD). Most of these studies identified an increase of LOOH because of increased oxidative stress [2,6,7,8,9,10]. LOOH is commonly treated as the end-product of an oxidative reaction intermediated by reactive oxygen species (ROS) or reactive nitrogen species.…”

Section: Introductionmentioning

confidence: 99%

Elimination of Lipid Peroxide during Hemodialysis

Obara

Hirayama²,

Gotoh³

et al. 2007

Nephron Clin Pract

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Background/Aims: This study is aimed to show the antioxidative effect of hemodialysis (HD) by demonstrating the elimination of toxic lipid peroxides. Methods: Blood samples were obtained from patients on regular maintenance HD before and 15, 30, 60, 120 and 240 min after the start of each HD session. Plasma cholesteryl ester hydroperoxide (CE-OOH), phosphatidylcholine hydroperoxide (PC-OOH), and eliminators of lipid peroxides (LOOH) such as apolipoprotein A-I (apoA-I) and lecithin:cholesterol acyltransferase (LCAT) were investigated. The hydroxyl radical scavenging activity was measured for the evaluation of the pro-oxidative side. Results: CE-OOH and PC-OOH were elevated in patients with chronic kidney disease both on and not on HD, while these values were much higher in HD patients. CE-OOH quickly dropped during the first 30 min of HD, then gradually decreased until 240 min. CE-OOH concentrations were related to those of apoA-I. In contrast, PC-OOH showed an increase 30 min after the start of HD, a change which resembled that of LCAT and was the reverse of the hydroxyl radical scavenging activity. Conclusion: These results demonstrate the antioxidative action through CE-OOH elimination involving apoA-I. The pro- and antioxidative effects of HD on LOOH are not uniform but PC-OOH is mainly influenced prooxidatively.

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“…Thus, the role of oxidative stress in life span determination remains unclear (Muller et al 2007). Antioxidant activities of FA as reported by several researchers (Bayés et al 2001;Joshi et al 2001;Racek et al 2005) motivated us to study the stressmodulating effects of FA in C. elegans. Our findings indicate a positive correlation between life span and oxidative stress tolerance, as FA-treated worms showed increased resistance to juglone-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

Rathor

Akhoon

Pandey

et al. 2015

AGE

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Folic acid (FA) is an essential nutrient that the human body needs but cannot be synthesized on its own. Fortified foods and plant food sources such as green leafy vegetables, beans, fruits, and juices are good sources of FA to meet the daily requirements of the body. The aim was to evaluate the effect of dietary FA levels on the longevity of well-known experimental aging model Caenorhabditis elegans. Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/ insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress-and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments.

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Homocysteine and lipid peroxidation in haemodialysis: role of folinic acid and vitamin E

Abstract: Treatment with folinic acid lowers plasma homocysteine levels and, like vitamin E, affords antioxidant protection, which prevents lipid peroxidation. This lowering of lipid peroxidation may reduce the risk of atherosclerosis and prevent or delay cardiovascular complications in HD patients.

Cited by 46 publications

References 29 publications

Effect of Antioxidant Vitamins on the Plasma Homocysteine Level in a Free-Living Elderly Population

Effect of Antioxidant Vitamins on the Plasma Homocysteine Level in a Free-Living Elderly Population

Elimination of Lipid Peroxide during Hemodialysis

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

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