Homocysteine and hemostatic disorder as a risk factor for myocardial infarction at a young age

Ogawa, Masanori; Abe, Satoshi; Saigo, Masahiko; Biro, Sadatoshi; Toda, Hitoshi; Matsuoka, Takahisa; Torii, Hiroyuki; Minagoe, Shinichi; Maruyama, Ikuro; Tei, Chuwa

doi:10.1016/s0049-3848(03)00242-1

Cited by 28 publications

(22 citation statements)

References 48 publications

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“…Although some previous studies failed to demonstrate an association between homocysteinemia and fibrinogenemia (39,40), in the present work their correlation was significant (r=0.31, p=0.013), as it was in the studies by De Luis et al (16) (42), and the association between homocysteinemia and fibrinogenemia in our study concurs with previous findings indicating activity of the coagulation system in the setting of HHcy (43)(44)(45).…”

Section: Discussionsupporting

confidence: 91%

Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy

Čabarkapa¹,

Đerić²,

Stosić³

et al. 2013

Journal of Medical Biochemistry

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Summary Background: One of the leading causes of terminal renal failure is diabetic nephropathy. The aim of this study was to determine the relationship between homocysteine levels and the biomarkers of renal function, inflammation and oxidative stress, as well as the incidence of macrovascular complications in patients with diabetic nephropathy. Methods: Sixty-four patients with diabetic nephropathy were included in this study. They were divided according to their homocysteine levels into two groups: hyperhomocysteinemic (HHcy, n=47) and normohomocysteinemic patients (NHCy, n=17). The re sults were compared to a control group (n=20) with normal renal function and without diabetes. Besides homocysteine, cystatine C, creatinine, urea, albuminuria, creatinine clearance, lipid status parameters, apolipoprotein A-I and B, lipo protein (a), CRP, fibrinogen, oxidative LDL were determined using appropriate methods. The incidence of macro vascular diabetic complications was also determined. Results: The results indicate that the level of renal dysfunction is greater in HHcy than in NHcy patients (p<0.05). In HHcy patients levels of oxLDL were also higher compared to NHcy patients (119.3±140.4 vs. 71.4±50.8 ng/mL, disp< 0.05) as well as fibrinogen levels (4.3±1.3 vs. 3.7±0.8 g/L, p<0.05). The in cidence of macrovascular complications is more frequent in HHcy than in NHcy patients (55.3. vs. 35.3 %, p>0.05), and in patients with macroalbuminuria compared to patients with microalbuminuria (65% vs. 39%, p<0.05). Conclusions: It can be concluded that HHcy is significantly present in patients with diabetic nephropathy, especially if there is greater reduction of renal function. Besides that, significantly higher concentrations of inflammatory (fibrinogen) and oxidative stress (oxLDL) markers were present in HHcy patients with diabetic nephropathy compared to NHcy patients.Therefore in diabetic nephropathy patients it is useful to regularly monitor the levels of homocysteine, as well as inflammatory and markers of oxidative stress.

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Section: Discussionsupporting

confidence: 91%

Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy

Čabarkapa¹,

Đerić²,

Stosić³

et al. 2013

Journal of Medical Biochemistry

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“…The cardiovascular risk factors, the extent of coronary artery disease and clinical outcome after ACS might be different from those of older patients. [5][6][7][8] Acute coronary syndrome is not uncommon in the young population as previously thought. Undersuspicion of the diagnosis and mostly attributing chest pain or epigastric pain to either acid peptic disorder or alternative musculoskeletal causes leads to misdiagnosis and mismanagement of the patients.…”

Section: Introductionmentioning

confidence: 99%

Acute coronary syndrome in the young Nepalese population with their angiographic characteristics

Laudari

Dhungel

Dubey

et al. 2017

J Coll Med Sci-Nepal

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Background & Objectives: Acute cor onar y syndr ome (ACS) is an emerging cardiac problem in the young population in Asia and Nepalese population is not an exception to this. Early ACS in young age imparts huge familial and social economic burden. Early identification and proper management strategy is still a challenging problem in developing countries like Nepal where there are limited coronary intervention centers. The study was conducted with objective to study the clinical spectrum, etiologies, coronary angiographic characteristics and their clinical outcomes. Materials & Methods: This is a cross-sectional study carried out in a tertiary hospital in central Nepal. Forty patients with acute coronary syndrome with age less than 40 years were enrolled in the study. Results: Majority of the patients were males with male: female=1.8:1. Twenty six (65%) patients were having ST segment elevation myocardial infarction followed by non-ST elevation myocardial infarction in nine (22.50%) patients and unstable angina in five (12.50%). patients. The most common risk factors were smoking, systemic hypertension, diabetes mellitus and dyslipidemia. Majority were having single vessel disease. Twenty (50%) patients had undergone primary angioplasty followed by thrombolysis in seven patients and the rest were managed medically because of late presentation. In-hospital major adverse cardiac events and mortality were higher among STEMI than NSTEMI and unstable angina. Conclusion: Acute coronary syndrome in the young is increasing in the Nepalese population. This group of population should be well educated and made aware of the potential coronary risk factors and their modification.

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“…It is now well documented that elevation of total plasma homocysteine level in a fasting state is associated with an increased risk of cardiovascular disease; such as myocardial infarction [9,10], stroke [11,12], and carotid intimal-medial wall thickening [13]. Extensive research of recent decade has been shown that, it is an independent risk factor for vascular disease similar to smoking or hyperlipidemia [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Extensive research of recent decade has been shown that, it is an independent risk factor for vascular disease similar to smoking or hyperlipidemia [9,10].…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia and central retinal vein occlusion in Iranian population

et al. 2007

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Homocysteine and hemostatic disorder as a risk factor for myocardial infarction at a young age

Cited by 28 publications

References 48 publications

Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy

Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy

Acute coronary syndrome in the young Nepalese population with their angiographic characteristics

Hyperhomocysteinemia and central retinal vein occlusion in Iranian population

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