Hyperhomocysteinemia and central retinal vein occlusion in Iranian population

Moghimi, Sasan; Najmi, Zahra; Faghihi, Hooshang; Karkhaneh, Reza; Farahvash, Mohammad Sadegh; Maghsoudipour, Maryam

doi:10.1007/s10792-007-9103-4

Cited by 15 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Homocysteine was found to be elevated in various other population-based studies such as the Iranian and the Chinese. They reported it as a risk factor for CRVO 19 20. Similar to our earlier study, Latanzio et al 21 reported that homocysteine was the risk factor for early onset CRVO.…”

Section: Discussionsupporting

confidence: 79%

Homocysteine induces oxidative stress in young adult central retinal vein occlusion

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 79%

Homocysteine induces oxidative stress in young adult central retinal vein occlusion

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The estimates from studies in which control patients had mostly other diseases were fairly homogenous. 18,10,22,24,30,45,58,59,60 The mean tHcy was 1.83 mol/L (95% CI, 1.3-2.3; PϽ0.001) greater in cases than in the controls in this group.…”

Section: Total Homocysteinementioning

confidence: 73%

Homocysteine, Methylenetetrahydrofolate Reductase C677T Polymorphism, and Risk of Retinal Vein Occlusion: A Meta-analysis

McGimpsey¹,

Woodside²,

Cardwell³

et al. 2009

Ophthalmology

View full text Add to dashboard Cite

Objective: To assess the role of plasma total homocysteine (tHcy) concentrations and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T gene as risk factors for retinal vascular occlusive disease.Design: Retinal vein occlusion (RVO) is an important cause of vision loss. Early meta-analyses showed that tHcy was associated with an increased risk of RVO, but a significant number of new studies have been published.Participants and/or Controls: RVO patients and controls. Methods: Data sources included MEDLINE, Web of Science, and PubMed searches and searching reference lists of relevant articles and reviews. Reviewers searched the databases, selected the studies, and then extracted data. Results were pooled quantitatively using meta-analytic methods.Main Outcome Measures: tHcy concentrations and MTHFR genotype.Results: There were 25 case-control studies for tHcy (1533 cases and 1708 controls) and 18 case-control studies for MTHFR (1082 cases and 4706 controls). The mean tHcy was on average 2.8 mol/L (95% confidence interval [CI], 1.8 -3.7) greater in the RVO cases compared with controls, but there was evidence of between-study heterogeneity (PϽ0.001, I2 ϭ 93%). There was funnel plot asymmetry suggesting publication bias. There was no evidence of association between homozygosity for the MTHFR C677T genotype and RVO (odds ratio [OR] 1.20; 95% CI, 0.84 -1.71), but again marked heterogeneity (P ϭ 0.004, I 2 ϭ 53%) was observed. Conclusions: There was some evidence that elevated tHcy was associated with RVO, but not homozygosity for the MTHFR C677T genotype. Both analyses should be interpreted cautiously because of marked heterogeneity between the study estimates and possible effect of publication bias on the tHcy findings.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

show abstract

“…By undertaking a matched pair type of case control study, we could address the confounding effect of age and gender that was noted in different studies in the past. [78910] Hyperhomocysteinemia was a significant independent risk factor for RVO. In view of strict exclusion criteria, our study also ruled out other causes of CRVO affecting the association.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study

Wadani

Khandekar

Salim

et al. 2014

Indian J Ophthalmol

View full text Add to dashboard Cite

Background:We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients.Type of Study:Matched case control type of longitudinal study was conducted in 2006–2007.Materials and Methods:Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia.Results:We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60–47. 86), P = 2.1 × 10−13]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups.Conclusion:Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.

show abstract

Hyperhomocysteinemia and central retinal vein occlusion in Iranian population

Cited by 15 publications

References 35 publications

Homocysteine induces oxidative stress in young adult central retinal vein occlusion

Homocysteine induces oxidative stress in young adult central retinal vein occlusion

Homocysteine, Methylenetetrahydrofolate Reductase C677T Polymorphism, and Risk of Retinal Vein Occlusion: A Meta-analysis

Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study

Contact Info

Product

Resources

About