Homochiral MOF–Polymer Mixed Matrix Membranes for Efficient Separation of Chiral Molecules

Lu, Yizhihao; Zhang, Huacheng; Chan, Jun Yong; Ou, Ranwen; Zhu, Haijin; Forsyth, Maria; Marijanovic, Emilia M.; Doherty, Cara M.; Marriott, Philip J.; Holl, Mark Banaszak; Wang, Huanting

doi:10.1002/ange.201910408

Cited by 35 publications

(11 citation statements)

References 52 publications

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“…In derivative thermogravimetric (DTG) curves (Figure S7), a significant peak is observed in the temperature range of 253−390 °C for NH 2 -MOFs/TiNM, corresponding to the pyrolysis of His molecules. 24 However, no obvious peak in this range is observed in MOFs/TiNM. From 253 to 390 °C, the weight loss values of NH 2 -MOFs/ TiNM and MOFs/TiNM are 5.69 and 5.37% (Figure 3C).…”

Section: ■ Results and Discussionmentioning

confidence: 98%

“…Thermogravimetric analysis further verifies the incorporated ligands in NH 2 -MOFs/TiNM. In derivative thermogravimetric (DTG) curves (Figure S7), a significant peak is observed in the temperature range of 253–390 °C for NH 2 -MOFs/TiNM, corresponding to the pyrolysis of His molecules . However, no obvious peak in this range is observed in MOFs/TiNM.…”

Section: Results and Discussionmentioning

confidence: 99%

“…22,23 Motivated by this, chiral MOFs are post-synthetically modified with chiral molecules. 24,25 The successful chirality transcription is highly dependent on the rational selection of chiral molecules. Chiral hydroxyl (−OH) groups are widely utilized in enantioselective recognition.…”

mentioning

confidence: 99%

“…The elevated difficulties in seeking for suitable chiral ligands and complicated synthesis restrict the development of the research of chiral MOFs. However, a post-modification strategy admirably copes with these difficulties and realizes an attractive approach to modulating the functions and structures of MOFs. , Motivated by this, chiral MOFs are post-synthetically modified with chiral molecules. , The successful chirality transcription is highly dependent on the rational selection of chiral molecules. Chiral hydroxyl (−OH) groups are widely utilized in enantioselective recognition …”

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confidence: 99%

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Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers

Guo

Zhao

et al. 2023

Anal. Chem.

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Enantioselective identification of chiral molecules is of paramount importance in medical science, biochemistry, and pharmaceutics owing to the configuration-dependent activities of enantiomers. However, the identical physicochemical properties of enantiomers remain challenging in chiral sensing. In this study, inspired by the peroxidase-mimicking activity of Fe(III)-based nanomaterials, an enantioselective artificial architecture is constructed on TiO2 nanochannels. Homochiral Ti-based metal–organic frameworks (MOFs) use a 2,2′-bipyridine-5,5′-dicarboxylic acid ligand as the artificial enzyme skeleton, Fe(III) as peroxidase-mimicking centers, and l-tartaric acid (TA) as a chiral recognition selector. Using l-/d-cystine as model enantiomers, the chiral moieties of l-TA on Ti-MOFs allow stereoselective recognition of guest molecules through hydrogen bonds formed between chiral cystine and the host. In a tris(2-carboxyethyl)phosphine hydrochloride-containing environment, the disulfide bonds in cystine molecules are further cleaved, and the HS-tails react with Fe(III) active sites, causing the loss of peroxidase-like performance of nanochannels. Benefitting from the nanochannel architecture’s current–potential (I–V) properties, the selective recognition of cystine enantiomers is directly monitored through the peroxidase-like activity change-induced ionic current signatures. This study provides a new and universal strategy for distinguishing disulfide- and thiol-containing chiral molecules.

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Section: ■ Results and Discussionmentioning

confidence: 98%

Section: Results and Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers

Guo

Zhao

et al. 2023

Anal. Chem.

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“…These membranes have advantages of providing high surface area, varying functionalities, tunable and pore size. Due to multitude of properties, these are widely used in drug delivery systems, chemical sensors, gas storage and catalysis ( Lu et al, 2019 ).…”

Section: Applicationsmentioning

confidence: 99%

Recent progress in the design, synthesis and applications of chiral metal-organic frameworks

et al. 2022

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Chiral Metal-Organic Frameworks (CMOFs) are unique crystalline and porous class of materials which is composed of organic linkers and metal ions. CMOFs surpass traditional organic and inorganic porous materials because of their tunable shape, size, functional diversity, and selectivity. Specific applications of CMOFs may be exploited by introducing desired functional groups. CMOFs have chiral recognition abilities, making them unique for chiral compound synthesis and separation. The CMOFs can be synthesized through different approaches. Two main approaches have been discussed, i.e., direct and indirect synthesis. Synthetic strategies play an essential role in getting desired properties in MOFs. CMOFs find potential applications in adsorption, asymmetric catalysis, luminescence, degradation, and enantioselective separation. The MOFs’ porosity, stability, and reusability make them an attractive material for these applications. The plethora of applications of CMOFs have motivated chemists to synthesize novel MOFs and number of MOFs have been ever-escalating. Herein, the synthetic methods of CMOFs and their various applications have been discussed.

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Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

et al. 2021

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Chirality has become an important research subject. The research areas associated with chirality are under substantial development. Meanwhile, graphene is a rapidly growing star material and has hard‐wired into diverse disciplines. Rational combination of graphene and chirality undoubtedly creates unprecedented functional materials and may also lead to great findings. This hypothesis has been clearly justified by the sizable number of studies. Unfortunately, there has not been any previous review paper summarizing the scattered studies and advancements on this topic so far. This overview paper attempts to review the progress made in chiral materials developed from graphene and their derivatives, with the hope of providing a systemic knowledge about the construction of chiral graphenes and chiral applications thereof. Recently emerging directions, existing challenges, and future perspectives are also presented. It is hoped this paper will arouse more interest and promote further faster progress in these significant research areas.

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Homochiral MOF–Polymer Mixed Matrix Membranes for Efficient Separation of Chiral Molecules

Cited by 35 publications

References 52 publications

Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers

Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers

Recent progress in the design, synthesis and applications of chiral metal-organic frameworks

Chiral Graphene Hybrid Materials: Structures, Properties, and Chiral Applications

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