Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in the Diagnosis of Insulin Resistance and Prediabetes

Bhosle, Deepak; Sayyed, Asif; Bhagat, Abhijeet; Sheikh, Huzaif; Londhe, Vasundhara

doi:10.18535/jmscr/v4i9.65

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…24,25 Although a continuing increase awareness of diabetes was found in self-reported, the diabetes percentage control in 2017 remained the same stage as in 2013; 26 significant hyperglycemia. 28 HOMA-β index is used to quantifies β-cell function and mass, 29 which was observed that there had no significant difference changes in the four groups of the present study.…”

Section: Discussionmentioning

confidence: 55%

“…HOMA‐IR index is used for evaluation of insulin resistance, which has a great relationship with the results of glucose clamp measurement in subjects without significant hyperglycemia 28 . HOMA‐β index is used to quantifies β‐cell function and mass, 29 which was observed that there had no significant difference changes in the four groups of the present study.…”

Section: Discussionmentioning

confidence: 58%

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Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF‐κB pathway

Zhu,

Li,

et al. 2024

Environmental Toxicology

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The purpose of this study was to explore the effects of combined lead (Pb) and two types of microplastic (MP) (polyvinyl chloride [PVC] and polyethylene [PE]) exposure on glucose metabolism and investigate the role of the nuclear factor erythroid 2‐related factor 2 (Nrf2)/nuclear factor‐kappa B (NF‐κB) signaling pathway in mediating these effects in mice. Adult C57BL/6J mice were randomly divided into four groups: control, Pb (100 mg/L), MPs (containing 10 mg/L PE and PVC), and Pb + MPs, each of which was treated with drinking water. Treatments were conducted for 6 weeks. Co‐exposure to Pb + MPs exhibited increase glycosylated serum protein levels, insulin resistance, and damaged glucose tolerance compared with the control mice. Additionally, treatment with Pb + MPs caused more severe damage to hepatocytes than when exposed to them alone concomitantly, exposed to Pb + MPs exhibited improved the levels of interleukin‐6, tumor necrosis factor‐alpha, and malondialdehyde, but reduced superoxide dismutase, glutathione peroxidase, and catalase assay in livers. Furthermore, they increase the Kelch‐like ECH‐associated protein 1 (Keap1) and phosphorylated p‐NF‐κB protein levels but reduced the protein levels of heme oxygenase‐1 and Nrf2, as well as increased Keap1 mRNA and Nrf2 mRNA. Co‐exposure to Pb + MP impacts glucose metabolism via the Nrf2 /NF‐κB pathway.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 58%

Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF‐κB pathway

Zhu,

Li,

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

Cardiometabolic risk factors in patients with chronic obstructive pulmonary disease and obesity

Овсянников¹,

Авдеев²,

Будневский³

et al. 2019

Profil. med.

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Correction of disorders of carbohydrate and lipid metabolism in patients with infertility during the stage of preparation for in vitro fertilization

Krasnopolskaya¹,

Оразов²,

Sokolova³

et al. 2022

Ross. vestn. akush.-ginekol.

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Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in the Diagnosis of Insulin Resistance and Prediabetes

Abstract: Type 2 diabetes mellitus consists of metabolic disturbances characterised mainly characterized by hyperglycemia which usually result from the combination of resistance to insulin action

Cited by 4 publications

References 18 publications

Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF‐κB pathway

Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF‐κB pathway

Cardiometabolic risk factors in patients with chronic obstructive pulmonary disease and obesity

Correction of disorders of carbohydrate and lipid metabolism in patients with infertility during the stage of preparation for in vitro fertilization

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