Homeopathic Symphytum officinale increases removal torque and radiographic bone density around titanium implants in rats

Abstract

We conclude that S. officinale 6cH enhances, principally at the early stages of osseointegration, bone formation around titanium implants in rats' tibiae, based on radiographic and mechanical analysis.

Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants

“…Torque removal analysis is a test commonly performed to evaluate the strength of the bone‐implant interface . It has been demonstrated that ALN therapy significantly increases the values of implant torque removal .…”

Integrative approach to fracture healing: A review

“…These cases included a delayed union case of a fracture of os naviculare, a fatigue fracture case and a case of posttraumatic pseudarthrosis of sternum. Similarly, in 2008 and in 2010, Sakakura and colleagues showed that Symphytum officinale enhances osseointegration and bone formation around the titanium implants of tibiae of rats [13,14].…”

The impact of medication on osseointegration and implant anchorage in bone determined using removal torque—A review

“… Tibia 28 −32.3 - ( Tekin et al., 2021b ) ± Propranolol h.d. 0.0 - Solcoseryl Systemic Rabbit, JW CCEF ± solcoseryl Femur 14 5.6 30.0 ( Ochi et al., 2003 ) Collagen-CS Local Rat, Wistar OVX ± Collagen-CS Tibia 14 22.6 30.7 ( Stadlinger et al., 2013 ) 28 21.4 39.3 Fibrinogen Local Rat, SD ± Fibrinogen Tibia 14 −52.3 - ( Wermelin et al., 2008 ) S. officinale Systemic Rat, Holtzman ± S. officinale Tibia 7 18.6 - ( Spin-Neto et al., 2010 ) 14 33.3 - 28 −12.1 - 56 −22.2 - ASU Systemic Rat, Wistar ± ASU Tibia 60 6.0 24.0 ( de Oliveira et al., 2014 ) ASU Systemic Rat, Holtzman Arthritis ± ASU Tibia 14 −20.4 14.6 ( de Paula et al., 2018 ) 30 ...…”