Home use of binocular dichoptic video content device for treatment of amblyopia: a pilot study

Mezad-Koursh, Daphna; Rosenblatt, Amir; Newman, Hadas; Stolovitch, Chaim

doi:10.1016/j.jaapos.2017.12.012

Cited by 25 publications

(34 citation statements)

References 27 publications

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“…Therefore, binocular training strategies have emerged, focusing on treating the primary binocular disorder [25–37]. These are based on dichoptic image presentation that the subject needs to binocularly combine to have full information content of a global motion stimulus [24], a video game [27, 28, 38], a movie [36, 39, 40], or an altered reality device [25, 41]. Binocular fusion only occurs if the contrast of the image seen by the nonamblyopic eye is reduced sufficiently to address the interocular imbalance resulting from suppression.…”

Section: Introductionmentioning

confidence: 99%

“…These procedures are based on the presentation of complementary images in the two eyes. Passive dichoptic movie watching resulted in benefits for visual acuity in children [36, 39] but has not been tested on adults yet. In principle, this method could be applied to the passive viewing of any video content such as sporting programs, movies, or children's animations [40].…”

Section: Introductionmentioning

confidence: 99%

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Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period

et al. 2019

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Dichoptic movie viewing has been shown to significantly improve visual acuity in amblyopia in children. Moreover, short-term occlusion of the amblyopic eye can transiently increase its contribution to binocular fusion in adults. In this study, we first asked whether dichoptic movie viewing could improve the visual function of amblyopic subjects beyond the critical period. Secondly, we tested if this effect could be enhanced by short-term monocular occlusion of the amblyopic eye. 17 subjects presenting stable functional amblyopia participated in this study. 10 subjects followed 6 sessions of 1.5 hour of dichoptic movie viewing (nonpatched group), and 7 subjects, prior to each of these sessions, had to wear an occluding patch over the amblyopic eye for two hours (patched group). Best-corrected visual acuity, monocular contrast sensitivity, interocular balance, and stereoacuity were measured before and after the training. For the nonpatched group, mean amblyopic eye visual acuity significantly improved from 0.54 to 0.46 logMAR (p<0.05). For the patched group, mean amblyopic eye visual acuity significantly improved from 0.62 to 0.43 logMAR (p<0.05). Stereoacuity improved significantly when the data of both groups were combined. No significant improvement was observed for the other visual functions tested. Our training procedure combines modern video technologies and recent fundamental findings in human plasticity: (i) long-term plasticity induced by dichoptic movie viewing and (ii) short-term adaptation induced by temporary monocular occlusion. This passive dichoptic movie training approach is shown to significantly improve visual acuity of subjects beyond the critical period. The addition of a short-term monocular occlusion to the dichoptic training shows promising trends but was not significant for the sample size used here. The passive movie approach combined with interocular contrast balancing even over such a short period as 2 weeks has potential as a clinical therapy to treat amblyopia in older children and adults.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period

et al. 2019

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“…In 2018, preliminary results were reported of a level III study of BinoVision, a binocular, head-mounted video goggle system designed for dichoptic stimulation connected to a personal computer that stored children's television shows and movies. 37 This study enrolled children aged 4 to 8 years and assigned them to the dichoptic study group (n ¼ 19) for 8 to 12 weeks or a sham group (n ¼ 8) for 4 weeks. All patients were instructed to watch animated programs at home for 60 minutes per day, 6 days per week.…”

Section: Amblyopic Eye Visual Acuitymentioning

confidence: 99%

“…In these 7 subjects, the median stereoacuity improved from 170 arc seconds (interquartile 230 arc seconds) to 85 arc seconds (interquartile 30 arc seconds) (P ¼ 0.0215). In the level III study of BinoVision by Mezad-Koursh et al, 37 the 2 patients with stereoacuity present at enrollment maintained stereopsis and 3 additional patients obtained stereoacuity of 400 arc seconds or better.…”

Section: Binocularity and Sensory Outcomes Such As Stereopsismentioning

confidence: 99%

Binocular Treatment of Amblyopia

Pineles¹,

Aakalu

Hutchinson

et al. 2020

Ophthalmology

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Purpose: To review the published literature assessing the efficacy of binocular therapy for the treatment of amblyopia compared with standard treatments.Methods: Literature searches with no date restrictions and limited to the English language were conducted in January 2018 and updated in April 2019 in the PubMed database and the Cochrane Library database with no restrictions. The search yielded 286 citations, and the full text of 50 articles was reviewed. Twenty articles met the inclusion criteria for this assessment and were assigned a level of evidence rating by the panel methodologist. Six studies were rated level I, 1 study was rated level II, and 13 studies were rated level III because of the impact on the development and popularization of this technology.Results: Two of the level I and II studies reviewed described a significant improvement in visual acuity in the binocular group versus standard patching standard treatment (the total number of patients in these 2 studies was 147). However, the 5 studies that failed to show a visual improvement from binocular therapy compared with standard treatments were larger and more rigorously designed (the total number of patients in these 5 studies was 813). Level I and II studies also failed to show a significant improvement over baseline in sensory status, including depth of suppression and stereopsis of those treated with binocular therapy. Several smaller level III case series (total number of patients in these 13 studies was 163) revealed more promising results than the binocular treatments studied in the level I and II studies, especially using treatments that are more engaging and are associated with better compliance.Conclusions: There is no level I evidence to support the use of binocular treatment as a substitute for current therapies for amblyopia (including patching and optical treatment). Furthermore, 2 large randomized controlled trials showed inferior performance compared with standard patching treatment. On the basis of this review of the published literature, binocular therapy cannot be recommended as a replacement for standard amblyopia therapy. However, more research is needed to determine the potential benefits of proposed binocular treatments in the future. Ophthalmology 2020;127:261-272 ª 2019 by the American Academy of OphthalmologyThe American Academy of Ophthalmology prepares Ophthalmic Technology Assessments to evaluate new and existing procedures, drugs, and diagnostic and screening tests. The goal of an Ophthalmic Technology Assessment is to systematically review the available research for clinical efficacy, effectiveness, and safety. After review by members of the Ophthalmic Technology Assessment Committee, other assessments by Academy committees, relevant subspecialty societies, and legal counsel are submitted to the Academy's Board of Trustees for consideration as official Academy statements. The purpose of this assessment by the Ophthalmic Technology Assessment Committee Pediatric Ophthalmology/Strabismus Panel was to review the publis...

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“…Das Stereosehen verbesserte sich in beiden Gruppen ähnlich um 0,06 log arcsec zu 0,07 log arcsec. Eine Pilotstudie aus dem gleichen Jahr mit 27 Kindern zwischen 8 und 12 Jahren zeigte nach Durchführung eines dichoptischen Programms einen Visusanstieg von 0,25 LogMAR nach einem Zeitraum von 12 Wochen [43].…”

Section: Dichoptisches Trainingunclassified

Digital and Technical Developments in the Amblyopia Therapy

Schramm

Wenner

2020

Klin Monbl Augenheilkd

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The digital media becomes more and more common in our everyday lives. So it is not surprising that technical progress is also leaving its mark on amblyopia therapy. New media and technologies can be used both in the actual amblyopia therapy or therapy monitoring. In particular in this review shutter glasses, therapy monitoring and analysis using microsensors and newer video programs for amblyopia therapy are presented and critically discussed. Currently, these cannot yet replace classic amblyopia therapy. They represent interesting options that will occupy us even more in the future.

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Home use of binocular dichoptic video content device for treatment of amblyopia: a pilot study

Cited by 25 publications

References 27 publications

Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period

Contribution of Short-Time Occlusion of the Amblyopic Eye to a Passive Dichoptic Video Treatment for Amblyopia beyond the Critical Period

Binocular Treatment of Amblyopia

Digital and Technical Developments in the Amblyopia Therapy

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