Background: Children with cerebral palsy (CP) may have significant difficulties while dealing with daily environmental requests. Telerehabilitation (TR) may be a valid way to improve their quality of life and promote their independence. Objectives: The objectives of the study were to assess the use of TR in children with CP, to evaluate their feasibility, effectiveness, and suitability in their daily life, and to examine its effects on both caregivers and families' burden. Methods: A mini review on the newest empirical evidence available was carried out. Some significant contributions we emphasized. Some useful insights were highlighted. Some helpful guidelines were evidenced. Results: Data demonstrated the usability and the validity of TR in children with CP. Their quality of life was relevantly enhanced and caregivers' burden reduced. Conclusion: TR may be considered a valid way to improve the quality of life of children with CP by improving their self-determination and decreasing families' burden.