Home-Based tDCS: Applications and Approaches, Design, Feasibility, and Safety

Alonzo, Angelo; Charvet, Leigh

doi:10.1007/978-3-030-76136-3_36

Cited by 1 publication

(1 citation statement)

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“…The DiSCoVeR trial is topical due to its development toward home-treatment, providing a remotely supervised domestic intervention beyond institutionalized or clinical care. To date, only few studies have investigated the feasibility and tolerability of remotely applied supervised tDCS at home [ 96 – 101 ]. The self-administered delivery of the intervention in the DiSCoVeR trial is enabled using a novel electrode-positioning algorithm incorporated into the home-application capturing individual facial key points, as well as a marker placed on the cap for control and adjustment of the electrode positioning.…”

Section: Discussionmentioning

confidence: 99%

Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol

Dechantsreiter

Padberg

Morash

et al. 2022

Eur Arch Psychiatry Clin Neurosci

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Enhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompassing transcranial direct current stimulation (tDCS) along with a video game based training of attentional control. The study is designed as a two-arm, double-blind, randomized and placebo-controlled multi-center trial (ClinicalTrials.gov: NCT04953208). At three study sites (Israel, Latvia, and Germany), 114 patients with a primary diagnosis of MDD undergo 6 weeks of intervention (30 × 30 min sessions). Patients assigned to the intervention group receive active tDCS (anode F3 and cathode F4; 2 mA intensity) and an action-like video game, while those assigned to the control group receive sham tDCS along with a control video game. An electrode-positioning algorithm is used to standardize tDCS electrode positioning. Participants perform their designated treatment at the clinical center (sessions 1–5) and continue treatment at home under remote supervision (sessions 6–30). The endpoints are feasibility (primary) and safety, treatment efficacy (secondary, i.e., change of Montgomery-Åsberg Depression Rating Scale (MADRS) scores at week six from baseline, clinical response and remission, measures of social, occupational, and psychological functioning, quality of life, and cognitive control (tertiary). Demonstrating the feasibility, safety, and efficacy of this novel combined intervention could expand the range of available treatments for MDD to neuromodulation enhanced interventions providing cost-effective, easily accessible, and low-risk treatment options.ClinicalTrials.gov: NCT04953208.

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Section: Discussionmentioning

confidence: 99%