Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula

Abstract

Two new sesquiterpenoids, homalolides CD (1-2), were co-isolated from the rhizomes of Homalomena pendula collected in Vietnam with five known ones, aromadendrane-4α,10αdiol (3), bullatantriol (4), 1β,4β,6α-trihydroxy-eudesmane (5), 1β,4β,6β-trihydroxyeudesmane (6), and 1β,4β,7α-trihydroxy-eudesmane (7). The structures and relative configuration of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature. Homalolide C presented an unprecedented skeleton with the 4/8 bicyclic system. All isolates did not exhibit appreciable inhibitory effects on LPS-induced NO production in the RAW 264.7 macrophage cell line and on the growth of human lung cancer cell line (SK-LU-1).

Volatile Components and Biological Activities of n-Hexane Extract From Rhizomes of Homalomena cochinchinensis

“…6,7 Investigating the composition and biological activities of H cochinchinensis rhizomes is important for clarifying the role of this plant in folk medicine. As part of an ongoing investigation of bioactive metabolites from plants of the Homalomena genus collected in Vietnam, [8][9][10] we report herein the composition of volatile components from H cochinchinensis rhizomes. We also investigated the extract's cytotoxic activity against SK-LU-1 (human lung adenocarcinoma), HepG2 (human hepatocellular carcinoma), and MCF7 (human breast cancer) cell lines; its inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells; and its capacity for acetylcholinesterase (AChE) inhibition.…”