Hollow Silica Nanocontainers as Drug Delivery Vehicles

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Designed Fabrication of Silica-Based Nanostructured Particle Systems for Nanomedicine Applications

“…Similarly, Huh and co-workers [103] synthesized a novel hollow silica nanoparticle (HSNP) architecture for drug delivery vehicles using silica-coated magnetic assemblies as templates. The core cavity was obtained by removal of the Fe 3 O 4 seed particle with hydrochloric acid and subsequent calcination of the shell at high temperatures.…”

Poly(ethylene glycol)‐Graft‐Hollow Silica Vesicles for Drug Delivery

“…[18][19][20][21][22] Polylelectrolyte-multilayer-coated hollow silica spheres showed salt-induce drug release, [23] and PEG layers were applied to reduce the ultrasonication-triggered drug release rate from hollow silica spheres. [24] However, hollow silica spheres with suitable polymer stealth layers are not reported. Nevertheless, it is reasonable to expect that vesicles with excellent performances can be obtained by grafting dense polymer brushes onto nanosized hollow silica spheres.…”

Silica and ORMOSIL nanoparticles for gene delivery

“…Later the template will be removed by chemical etching or thermal degradation ( Figure 12). Hollow-sphere NPs are capable of carrying large amounts of payload or filling their cores with other desirable materials such as polymers, gold or silver [30][31][32][33][34][35] along with the gene delivery performance. Figure 13 shows TEM images of hollow SiO2 NPs and illustrates the FTIR of all stages of the synthesis process.…”