Poly(ethylene glycol)‐Graft‐Hollow Silica Vesicles for Drug Delivery

Lay, Chee Leng; Liu, Hui Qi; Wu, Decheng; Liu, Ye

doi:10.1002/chem.200903291

Cited by 46 publications

(33 citation statements)

References 38 publications

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“…The IBU-loaded magnetite particle carriers (20 mg) were added into a dialysis tube (cut-off M n = 5000) with buffer solutions (3 mL) with different pH values and immersed into 27 mL of the same solution at 37 8C under gentle stirring. [39,40] Aliquots (3 mL) were taken out from the solution periodically. After each sampling, the volume of the solution in a cuvette was put back into the vessel.…”

Section: Methodsmentioning

confidence: 99%

Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

Dong

Guo

Bae

et al. 2011

Chemistry A European J

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Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141 m(2) g(-1). Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF-7 cell and in vitro constant drug release behavior combined with the high drug loading efficiency and high saturation magnetization values demonstrated the potential of the as-synthesized magnetite materials in targeted drug release systems.

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Section: Methodsmentioning

confidence: 99%

Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

Dong

Guo

Bae

et al. 2011

Chemistry A European J

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“…The former strategy involves the preparation of silica NPs with hollow structures, into which drugs are loaded after NP formation (Fig. 3b); this is one of the methods for encapsulation [46, 51–54, 83–85]. This process results in a non-covalent binding between drug and silica matrix, which is similar to that used for adsorption of drugs in meso pores of mesoporous silica NPs.…”

Section: Silica Nps For Drug Deliverymentioning

confidence: 99%

Nonporous silica nanoparticles for nanomedicine application

2013

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Summary Nanomedicine, the use of nanotechnology for biomedical applications, has potential to change the landscape of the diagnosis and therapy of many diseases. In the past several decades, the advancement in nanotechnology and material science has resulted in a large number of organic and inorganic nanomedicine platforms. Silica nanoparticles (NPs), which exhibit many unique properties, offer a promising drug delivery platform to realize the potential of nanomedicine. Mesoporous silica NPs have been extensively reviewed previously. Here we review the current state of the development and application of nonporous silica NPs for drug delivery and molecular imaging.

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“…[18][19][20][21][22][23] Recently we suggested that it is promising to prepare vesicles with excellent performances by grafting dense polymer brushes to nanosized hollow silica spheres. [24] The porous …”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Poly(methacrylic acid)‐Grafted Hollow Silica Vesicles

Lay

Tan

et al. 2011

Chemistry A European J

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Poly(methacrylic acid)-grafted hollow silica vesicles (PMAA-g-hollow silica vesicles) were obtained through a grafting-from approach. PMAA brushes were formed by performing atom-transfer radical polymerisation of sodium methacrylate with an initiator attached to the hollow silica spheres. PMAA-g-hollow silica vesicles were characterised by using TEM, thermogravimetric analysis (TGA) and FTIR spectroscopy. pH-dependent ξ potential and (1)H NMR spectra of PMAA-g-hollow silica vesicles were measured, and the results indicated that MAA brushes in PMAA-g-hollow silica vesicles had a lower ionisation degree and low solubility in acidic aqueous solution, for example, pH 3.4, but a higher ionisation degree and high solubility when the pH was higher than 7. Also it was demonstrated that calcein blue and fluorescein isothiocyanate (FITC) labelled dextran (M(n):10 kDa) could be encapsulated in the interiors of the PMAA-g-hollow silica vesicles with a negligible amount in PMAA brushes at pH 2, and pH-triggered release of calcein blue and FITC-labelled dextran from PMAA-g-hollow silica vesicles was observed at pH 7.4.

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Poly(ethylene glycol)‐Graft‐Hollow Silica Vesicles for Drug Delivery

Cited by 46 publications

References 38 publications

Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

Nonporous silica nanoparticles for nanomedicine application

pH‐Responsive Poly(methacrylic acid)‐Grafted Hollow Silica Vesicles

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