Hollow iron oxide nanomaterials: synthesis, functionalization, and biomedical applications

Wei, Ruixue; Xu, Youyun; Xue, Mengzhou

doi:10.1039/d0tb02858d

Cited by 33 publications

(26 citation statements)

References 114 publications

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“…Unfortunately, the chemical exchange between inner iron ions and protons have been blocked by the outershell, resulting in a reduction of the number of effective iron ions in IONP. Hollow structures with two interfaces between nanocrystal and surrounding environment can exceedingly rise the number of exposed magnetic ions, which is beneficial to elevate T 1 contrast of IONP [ [208] , [209] , [210] , [211] ]. Additionally, the hollow structure may disturb the long-range-order of magnetic spin and reduce magnetic moment, lowering the r 2 / r 1 ratio.…”

Section: Ionp As T 1 Camentioning

confidence: 99%

Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging

Zhao

Zeng

et al. 2022

Bioactive Materials

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Section: Ionp As T 1 Camentioning

confidence: 99%

Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging

Zhao

Zeng

et al. 2022

Bioactive Materials

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“…Compared to solid oxide nanoparticles, they have a much more significant spin canting effect, low magnetization, and a large surface‐to‐volume ratio. [ 144 ] They have acted as both T 1 and T 2 contrast agents. Zwitterionic dopamine sulfonate (ZDS)‐functionalized hollow, ultrasmall Fe 3 O 4 nanoparticles showed good T 1 positive contrast.…”

Section: Metal‐based Mri Contrast Agentsmentioning

confidence: 99%

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

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Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

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“…The preparation strategies for high-quality hollow DDSs can be divided into two main categories: (1) sacrificial template-based methods, which exploit a variety of removable nanoparticles as hard templates (e.g., silica, polystyrene and metal-organic frameworks (MOFs)) [ 56 – 61 ] or soft templates (e.g., Pluronic F127/TMB and gas bubbles) [ 62 , 63 ]; and (2) self-templating methods, which employ the transformation of self-generated internal solid nanoparticles to hollow structures during chemical reactions [ 64 – 68 ]. The former approach has been widely applied to produce various hollow nanoparticles with uniform morphology and a tuneable diameter and shell thickness, such as hollow MnO 2 [ 69 , 70 ], hollow polydopamine (PDA) [ 71 , 72 ], hollow carbon [ 73 , 74 ] and hollow mesoporous organosilica nanoparticles (HMON) [ 75 , 76 ], whereas the relatively recently developed latter approach is considered superior owing to the simple synthetic procedures and reduced formation of chemical waste [ 77 ]. For the self-templating method, the nanoscale Kirkendall effect, galvanic replacement reaction and Ostwald ripening process are often used to prepare hollow Cu 7 S 4 nanocrystals [ 78 ], Au−Ag@Au hollow nanostructures [ 79 ] and hollow cuprous oxide@nitrogen-doped carbon dual-shell structures [ 80 ], respectively.…”

Section: Introductionmentioning

confidence: 99%

Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies

et al. 2022

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Theranostic nanoplatforms integrating diagnostic and therapeutic functions have received considerable attention in the past decade. Among them, hollow manganese (Mn)-based nanoplatforms are superior since they combine the advantages of hollow structures and the intrinsic theranostic features of Mn2+. Specifically, the hollow cavity can encapsulate a variety of small-molecule drugs, such as chemotherapeutic agents, photosensitizers and photothermal agents, for chemotherapy, photodynamic therapy (PDT) and photothermal therapy (PTT), respectively. After degradation in the tumor microenvironment (TME), the released Mn2+ is able to act simultaneously as a magnetic resonance (MR) imaging contrast agent (CA) and as a Fenton-like agent for chemodynamic therapy (CDT). More importantly, synergistic treatment outcomes can be realized by reasonable and optimized design of the hollow nanosystems. This review summarizes various Mn-based hollow nanoplatforms, including hollow MnxOy, hollow matrix-supported MnxOy, hollow Mn-doped nanoparticles, hollow Mn complex-based nanoparticles, hollow Mn-cobalt (Co)-based nanoparticles, and hollow Mn-iron (Fe)-based nanoparticles, for MR imaging-guided cancer therapies. Finally, we discuss the potential obstacles and perspectives of these hollow Mn-based nanotheranostics for translational applications. Graphical Abstract Mn-based hollow nanoplatforms such as hollow MnxOy nanoparticles, hollow matrix-supported MnxOy nanoparticles, Mn-doped hollow nanoparticles, Mn complex-based hollow nanoparticles, hollow Mn-Co-based nanoparticles and hollow Mn-Fe-based nanoparticles show great promise in cancer theranostics.

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Hollow iron oxide nanomaterials: synthesis, functionalization, and biomedical applications

Abstract: Hollow iron oxide nanoparticles (NPs) are an attractive class of hollow nanostructures that have received significant attention in the biomedical field due to their low toxicity, good biocompatibility, and intrinsic...

Cited by 33 publications

References 114 publications

Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging

Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies

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