Hollow hydroxyapatite microspheres/chitosan composite as a sustained delivery vehicle for rhBMP-2 in the treatment of bone defects

Yao, Aihua; Li, Xudong; Xiong, Lei; Zeng, Jing; Xu, Jun; Wang, Deping

doi:10.1007/s10856-014-5336-8

Cited by 19 publications

(10 citation statements)

References 47 publications

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“…[52][53][54] For instance, microspheres of HA have been studied by many research teams for bioengineering applications due to their potential as local drug and protein delivery systems. [50,55,64,65,[56][57][58][59][60][61][62][63] On the other hand, few studies have investigated the incorporation of HA microspheres within polymeric matrices produced via AM. [65,66] Figure 3.…”

Section: Hydroxyapatitementioning

confidence: 99%

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Additive Manufacturing Approaches for Hydroxyapatite‐Reinforced Composites

Milazzo

Negrini

Scialla

et al. 2019

Adv Funct Materials

133

113

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Additive manufacturing (AM) techniques have gained interest in the tissue engineering field, thanks to their versatility and unique possibilities of producing constructs with complex macroscopic geometries and defined patterns. Recently, composite materials-namely, heterogeneous biomaterials identified as continuous phase (matrix) and reinforcement (filler)-have been proposed as inks that can be processed by AM to obtain scaffolds with improved biomimetic and bioactive properties. Significant efforts have been dedicated to hydroxyapatite (HA)-reinforced composites, especially targeting bone tissue engineering, thanks to the chemical similarities of HA with respect to mineral components of native mineralized tissues. Herein, applications of AM techniques to process HA-reinforced composites and biocomposites for the production of scaffolds with biological matrices, including cellular tissues, are reviewed. The primary outcomes of recent investigations in terms of morphological, structural, and in vitro and in vivo biological properties of the materials are discussed. The approaches based on the nature of the matrices employed to embed the HA reinforcements and produce the tissue substitutes are classified, and a critical discussion is provided on the presented state of the art as well as the future perspectives, to offer a comprehensive picture of the strategies investigated as well as challenges in this emerging field of materiomics.

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Section: Hydroxyapatitementioning

confidence: 99%

“…[50,55,64,65,[56][57][58][59][60][61][62][63] On the other hand, few studies have investigated the incorporation of HA microspheres within polymeric matrices produced via AM. [65,66] Figure 3. Hexagonal crystallographic structure of the hydroxyapatite crystal.…”

Section: Hydroxyapatitementioning

confidence: 99%

Additive Manufacturing Approaches for Hydroxyapatite‐Reinforced Composites

Milazzo

Negrini

Scialla

et al. 2019

Adv Funct Materials

133

113

View full text Add to dashboard Cite

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“…In view of the information mentioned above, the hydrogels/GMs+rhBMP2 scaffolds were the optimal delivery systems of rhBMP2 in the current study. Subsequent animal studies illustrated that the hydrogels/GMs+rhBMP2 did possess osteoinductive properties, and the rhBMP2 releasing from the scaffolds still maintained their bioactivity [28].…”

Section: Discussionmentioning

confidence: 99%

Bone morphogenetic protein-2 sustained delivery by hydrogels with microspheres repairs rabbit mandibular defects

Song

Liu

et al. 2016

Tissue Eng Regen Med

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Mandible defect is a difficult issue in dental surgery owing to limited therapeutic options. Recombinant human bone morphogenetic protein-2 (rhBMP2) is osteoinductive in bone regeneration. This article prepared chitosan/collagen hydrogels with rhBMP2-incorporated gelatin microsphere (GMs) for a sustained release of rhBMP2 to induce bone regeneration in rabbits. In experiments, mandibular defects of 8 mm in diameter and 3 mm in depth were surgically prepared on the right cheek of 27 rabbits. Either chitosan/collagen hydrogels alone, rhBMP2-incorporated hydrogels, or hydrogels with rhBMP2-incorporated GMs were implanted to the defect sites. The animals were euthanized at 2, 6, 12 weeks following surgery. In results, scanning electronic microscope images revealled spherical GMs. The complex delivery systems, hydrogels with rhBMP2-incorporated GMs, exhibited ideal release profiles in vitro. The complex delivery systems resulted in apparent new bone formation within 12 weeks, as evidenced by computed tomography and histological observations. All these results demonstrated that the chitosan/collagen hydrogels with rhBMP2-incorporated GMs had a better capacity to heal mandible defects than other two hydrogel scaffolds. Chitosan/collagen hydrogels with rhBMP2-incorporated GMs might be potential carriers of rhBMP2 for accelerating the repair of mandibular defects.

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“…An animal study identified that combining HAp with polymers improved the resorption rate of Hap 141 . Meanwhile, adding HAp onto several types of scaffolds has improved their bone regeneration potential 142–144 . Polymer/HAp composites have produced resorbable membranes for GBR applications 145 .…”

Section: Classificationmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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Hollow hydroxyapatite microspheres/chitosan composite as a sustained delivery vehicle for rhBMP-2 in the treatment of bone defects

Cited by 19 publications

References 47 publications

Additive Manufacturing Approaches for Hydroxyapatite‐Reinforced Composites

Additive Manufacturing Approaches for Hydroxyapatite‐Reinforced Composites

Bone morphogenetic protein-2 sustained delivery by hydrogels with microspheres repairs rabbit mandibular defects

A novel classification of bone graft materials

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