Hollow fiber liquid-phase microextraction combined with supercritical fluid chromatography coupled to mass spectrometry for multiclass emerging contaminant quantification in water samples

Salvatierra-Stamp, Vilma Del Carmen; Ceballos‐Magaña, Silvia G.; Pano-Farias, Norma S.; Leyva-Morales, José Belisario; Pineda‐Urbina, Kayim; Muñiz‐Valencia, Roberto

doi:10.1007/s00216-021-03202-0

Cited by 6 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmaceuticals can have different sources�mostly related to household discharge, but also hospital wastewater can contribute significantly. 29 In this study, especially antihypertensions (7), antibiotics (6), and antidepressants (5) were frequently detected. Ten compounds were detected in the class of potential drugs of abuse, as active ingredients or drug TPs.…”

Section: Resultsmentioning

confidence: 55%

“…Finally, due to decreased viscosity of the mobile phase, the kinetic efficiency improves, resulting in higher separation efficiency or faster analysis times. 7 However, the application of SFC in environmental analysis is still in its infancy. 4,8,9 Recent studies show especially the ability of detecting more polar compounds and their transformation products (TPs) in surface water and drinking water treatment systems by SFC.…”

Section: Introductionmentioning

confidence: 99%

“…(2022) observed that the sensitivity for compounds retained in both RP-LC and SFC was often higher in SFC–MS. Finally, due to decreased viscosity of the mobile phase, the kinetic efficiency improves, resulting in higher separation efficiency or faster analysis times . However, the application of SFC in environmental analysis is still in its infancy. ,, Recent studies show especially the ability of detecting more polar compounds and their transformation products (TPs) in surface water and drinking water treatment systems by SFC. , The detection of an increasing number of so far yet-undetected micropollutants in the environment increases the need to conduct a risk assessment of the samples by collecting exposure and toxicity data of the newly identified compounds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Supercritical Fluid Chromatography Coupled to High-Resolution Mass Spectrometry Reveals Persistent Mobile Organic Compounds with Unknown Toxicity in Wastewater Effluents

Tisler

Savvidou

Jørgensen³

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Broad screening approaches for monitoring wastewater are normally based on reversed-phase liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). This method is not sufficient for the very polar micropollutants, neglected in the past due to a lack of suitable analytical methods. In this study, we used supercritical fluid chromatography (SFC) to detect very polar and yet-undetected micropollutants in wastewater effluents. We tentatively identified 85 compounds, whereas 18 have only rarely been detected and 11 have not previously been detected in wastewater effluents such as 17α-hydroxypregnenolone, a likely transformation product (TP) of steroids, and 1H-indole-3-carboxamide, a likely TP from new synthetic cannabinoids. Suspect screening of 25 effluent wastewater samples from 8 wastewater treatment plants revealed several distinct potential pollution sources such as a pharmaceutical company and a golf court. The analysis of the same samples with LC−HRMS showed clearly how SFC increases the ionization efficiency for low-molecular-weight micropollutants (m/z < 300 Da) by a factor 2 to 87 times, which significantly improved the mass spectra for identifying very polar compounds. In order to assess which micropollutants might be of environmental concern, literature and toxicological databases were screened. There was a lack of available hazard and bio-activity data for regulatory-relevant in vitro and in vivo assays for >50% of the micropollutants. Especially, 70% of the data were lacking for the whole organism (in vivo) tests.

show abstract

Section: Resultsmentioning

confidence: 55%