Hole–Shell Microparticles from Controllably Evolved Double Emulsions

Wang, Wei; Zhang, Maojie; Xie, Rui; Ju, Xiao‐Jie; Yang, Chao; Mou, Chuan‐Lin; Weitz, David A.; Chu, Liang‐Yin

doi:10.1002/anie.201301590

Cited by 126 publications

(101 citation statements)

References 38 publications

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“…Recent progress in microfluidic fabrication of multiple emulsions has been summarized elsewhere . Monodisperse emulsions made with glass capillary‐based devices have been used in the synthesis of porous organic and inorganic microparticles, liquid crystal, and colloidal shells, patchy emulsions, and polyhedral microgels . These unique and highly ordered structures have found wide range of uses in pharmaceuticals, optical sensing and energy applications …”

Section: Introductionmentioning

confidence: 99%

Capillary‐Based Microfluidics—Coflow, Flow‐Focusing, Electro‐Coflow, Drops, Jets, and Instabilities

Guerrero

Chang

Fragkopoulos

et al. 2019

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Capillary‐based microfluidics is a great technique to produce monodisperse and complex emulsions and particulate suspensions. In this review, the current understanding of drop and jet formation in capillary‐based microfluidic devices for two primary flow configurations, coflow and flow‐focusing is summarized. The experimental and theoretical description of fluid instabilities is discussed and conditions for controlled drop breakup in different modes of drop generation are provided. Current challenges in drop breakup with low interfacial tension systems and recent progress in overcoming drop size limitations using electro‐coflow are addressed. In each scenario, the physical mechanisms for drop breakup are revisited, and simple scaling arguments proposed in the literature are introduced.

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Section: Introductionmentioning

confidence: 99%

Capillary‐Based Microfluidics—Coflow, Flow‐Focusing, Electro‐Coflow, Drops, Jets, and Instabilities

Guerrero

Chang

Fragkopoulos

et al. 2019

Small

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“…Monodisperse single droplets were generated in a fi rst droplet-formation junction, and were injected into a second level of single drops at a second dropletformation junction. [123][124][125][126][127] Water-in-oil-in-water (W/O/W) double-emulsion droplets could be prepared using the sequential emulsifi cation by modifying the microfl uidic channel surfaces to be hydrophobic in the fi rst junction and hydrophilic in the second junction, to avoid wetting problems. The opposite modifi cation of the microfl uidic channel surfaces is required for preparing the inverse oil-in-waterin-oil (O/W/O) double-emulsion droplets.…”

Section: Barcode Particles From Multiple Emulsionsmentioning

confidence: 99%

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Zhao

Cheng

Shang

et al. 2014

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The increasing use of high-throughput assays in biomedical applications, including drug discovery and clinical diagnostics, demands effective strategies for multiplexing. One promising strategy is the use of barcode particles that encode information about their specific compositions and enable simple identification. Various encoding mechanisms, including spectroscopic, graphical, electronic, and physical encoding, have been proposed for the provision of sufficient identification codes for the barcode particles. These particles are synthesized in various ways. Microfluidics is an effective approach that has created exciting avenues of scientific research in barcode particle synthesis. The resultant particles have found important application in the detection of multiple biological species as they have properties of high flexibility, fast reaction times, less reagent consumption, and good repeatability. In this paper, research progress in the microfluidic synthesis of barcode particles for multiplex assays is discussed. After introducing the general developing strategies of the barcode particles, the focus is on studies of microfluidics, including their design, fabrication, and application in the generation of barcode particles. Applications of the achieved barcode particles in multiplex assays will be described and emphasized. The prospects for future development of these barcode particles are also presented.

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“…[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71] In 2008, Weitz's group presented a monodisperse water-in-oil-in-water (W/O/W) double Pickering emulsion produced by using glass capillary microfluidic devices. 72 The reported microfluidic device combines a flow focusing and co-flowing geometry, which results in hydrodynamic flow focusing on three different fluid streams at the orifice of the collection tube and leads to the formation of double emulsion droplets.…”

Section: Microcapillary Devicementioning

confidence: 99%