HoffMann′s syndrome: A rare neurological presentation of hypothyroidism

Praveen, K.; Aslam, Sarfaraz; Tk, Dutta

doi:10.4103/2231-0738.84215

Cited by 9 publications

(15 citation statements)

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“…8 Muscle enlargement (pseudohypertrophy) is very rare and its etiology remains controversial. 9 Calf muscles (gastrocnemius) are commonly involved. 10 The thigh, arm, tongue and forearm muscles are involved to a lesser extent.…”

Section: Discussionmentioning

confidence: 99%

“…10 Postulated mechanisms for muscle pseudohypertrophy include increase deposition of Glycosaminoglycans, increase muscle fiber size and number. 9,10 Hypothyroidism is associated with change in muscle fiber type from fast twitch type II to slow twitch type I and alteration of oxidative muscle enzyme activity with decreased calcium ATPase activity of fast twitch type II fibers leading to delayed relaxation. 7,10 CPK levels are elevated in 70 -90% patients of hypothyroidism, but do not correlate with severity of weakness.…”

Section: Discussionmentioning

confidence: 99%

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Hoffmann’s Syndrome: A Case Report

Ak¹,

Chakraborty²,

Trivedi³

et al. 2014

jemds

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ABSTRACT:The neurological manifestations of hypothyroidism are very unusual to see as initial symptoms and they usually occur late in the course of disease. Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudohypertrophy. We present a case of 27 years old male presenting with features of proximal muscle weakness of both upper and lower limbs with hypertrophy of calf muscles. His TSH and CPK were markedly raised and EMG showed myopathic disorder. We report this case because of its rarity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hoffmann’s Syndrome: A Case Report

Ak¹,

Chakraborty²,

Trivedi³

et al. 2014

jemds

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“…Muscle pseudohypertrophy in HS is probably due to deposition of glycosaminoglycans and increased muscle fibre size [1,2]. The muscles commonly involved are the tongue, arm and leg muscles [2,3]. Calf muscles (gastrocnemius) are usually involved but generalized hypertrophy can occur [2,4].…”

mentioning

confidence: 99%

“…When such an entity occurs in children it is known as Kocher-Debre-Semelaigne syndrome. Differential diagnosis for calf muscle hypertrophy are muscular dystrophy (Duchenne, Becker), sarcoid granulomas, amyloid and focal myositis [2,3,5]. The indexed patient had elevated TSH with pseudohypertrophy of calf muscles so a diagnosis of HS was made.…”

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confidence: 99%

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Hoffmann’s Syndrome- A Rare Form of Hypothyroid Myopathy

Achappa¹

2017

JCDR

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Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature

Sindoni

Rodolico

Pappalardo

et al. 2016

Rev Endocr Metab Disord

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Abnormalities in thyroid function are common endocrine disorders that affect 5-10 % of the general population, with hypothyroidism occurring more frequently than hyperthyroidism. Clinical symptoms and signs are often nonspecific, particularly in hypothyroidism. Muscular symptoms (stiffness, myalgias, cramps, easy fatigability) are mentioned by the majority of patients with frank hypothyroidism. Often underestimated is the fact that muscle symptoms may represent the predominant or the only clinical manifestation of hypothyroidism, raising the issue of a differential diagnosis with other causes of myopathy, which sometimes can be difficult. Elevated serum creatine kinase, which not necessarily correlates with the severity of the myopathic symptoms, is certainly suggestive of muscle impairment, though it does not explain the cause. Rare muscular manifestations, associated with hypothyroidism, are rhabdomyolysis, acute compartment syndrome, Hoffman's syndrome and Kocher-Debré-Sémélaigne syndrome. Though the pathogenesis of hypothyroid myopathy is not entirely known, proposed mechanisms include altered glycogenolytic and oxidative metabolism, altered expression of contractile proteins, and neuro-mediated damage. Correlation studies of haplotype, muscle gene expression and protein characterization, could help understanding the pathophysiological mechanisms of this myopathic presentation of hypothyroidism.

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HoffMann′s syndrome: A rare neurological presentation of hypothyroidism

Cited by 9 publications

References 0 publications

Hoffmann’s Syndrome: A Case Report

Hoffmann’s Syndrome: A Case Report

Hoffmann’s Syndrome- A Rare Form of Hypothyroid Myopathy

Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature

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