Aims To study the risk factors, clinical and angiographic profile of Indian rural youth (under 35yrs) presenting with Premature Coronary Artery Disease (PCAD). Subjects and Methods: The PCAD registry had 1628 patients who were aged below 35 years, of which 681 patients satisfied the entry criteria. The data was analysed by statistical software R version 3.5.0. Results The study enrolled 681 patients after satisfying the entry criteria. The mean age of patients was 30.85 years. There were 405 (59.5%) aged between 30 and 35 yrs, 205 (30.1%) between 25 and 30 yrs, 64 (9.4%) between 20 and 25 yrs and 7 (1.0%) were aged less than 20 yrs. Majority of them were males, 617 (90.6%). Nearly 411 (60.4%) were smokers, 56patients (8.2%) were diabetics and 97 (14.2%) were hypertensives. Around 441 (64.8%) patients had low HDL cholesterol levels and 218 (32.0%) had elevated triglyceride levels. Abdominal obesity was seen in 443 (65.1%) patients. Most common clinical presentation was ST elevation myocardial infarction (STEMI) seen in 536 (78.7%) patients. Around 40% patients had recanalized/non obstructive/thrombotic/normal coronaries on coronary angiogram. Conclusions Conventional risk factors such as smoking, low HDL levels and abdominal obesity play a major role in the causation of premature coronary artery disease among the rural youth. Thrombotic milieu in the coronaries was commonly noted in coronary angiograms. Lack of awareness, combined with urbanisation of rural lifestyle could be responsible for increasing incidence of premature coronary artery disease in rural youth.
ABSTRACT:The neurological manifestations of hypothyroidism are very unusual to see as initial symptoms and they usually occur late in the course of disease. Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudohypertrophy. We present a case of 27 years old male presenting with features of proximal muscle weakness of both upper and lower limbs with hypertrophy of calf muscles. His TSH and CPK were markedly raised and EMG showed myopathic disorder. We report this case because of its rarity.
BACKGROUND Cardiovascular diseases (CVD) are major global health problem and reaching epidemic proportions in the Indian subcontinent and low and middle income countries, accounting for 78% of all deaths. The clinical spectrum, the age and gender-specific differences and the mortality rate in patients with ACS are not systematically studied in Tripura. In this background, a prospective cross sectional study was performed at Tripura Medical College and Dr. BRAM Teaching Hospital. RESULTS A total of 100 patients studied, out of which 75 were male and 25 were female. Mean age at presentation was 63.12±14.10 years. Cigarette smoking, dyslipidemia, obesity were the major risk factors. The prevalence of Hypertension, Diabetes mellitus, smoking, obesity, dyslipidemia and family history of CAD were 53%, 24%, 50%, 43%, 69% and 4% respectively. A significant number of patients (45%) presented late to the hospital after 6 hours' time. CONCLUSION STEMI is the major type of ACS prevalent in our region. The awareness of coronary artery disease in the study population appears to be low. Our study also reinforces the need to address the traditional risk factors to prevent the disease burden.
BACKGROUND: Uncontrolled Hypertension is an established risk factor for development of vascular diseases. Prevalence varies in different communities and as such no such study has been conducted systematically in rural people living in Tripura. The objective of this study was to determine the prevalence, awareness, and control of Hypertension in the community. METHODOLOGY: Population based survey was done in four villages of Tripura. Blood pressure and Anthropometric measurements were done in all subjects >18 yrs of age. Subjects were classified as hypertensive using JNC VII criteria or those on anti -hypertensive drugs. A total of 1600 subjects were examined. RESULTS: The prevalence of hypertension in rural population was 23.1% (370/1600) and this was higher in men. The overall prevalence of hypertension, stage 1 hypertension and stage 2 hypertension were 31.1%, 58.3% and 42.6% respectively. The hypertensive subjects were older and had significantly higher body-mass index compared to the normotensive group. Of these 370 subjects, only 29.3% (108/370) were known hypertensives and only 55 subjects (50.9%) were under antihypertensive therapy. Out of these 55 individuals only 24 (43.6%) had blood pressure under control. CONCLUSION: This study shows that prevalence of hypertension was higher than national average and the awareness and control of hypertension is still inadequate in rural population of Tripura. This study reinforces the need to urgently address the problem of hypertension in our state with established approaches to public and individual health. HOW TO CITE THIS ARTICLE:
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