Hodgkin??s Disease Associated With Other Malignant Tumors and Certain Nonneoplastic Diseases

Simultaneous Occurrence of Myeloma and Hodgkin’s Disease

“…It is now well established that there is an increased risk of second neo plasms associated with Hodgkin's disease with an overall incidence of 1.6 to 2.2% [3,9,10]. In a study of 425 patients with Hodgkin's disease, A rseneau el ai.…”

“…[2] observed a 3.5-fold increase in the risk of developing a second malignancy in all patients, with the greatest risk (29-fold) in a group of 35 patients who had received both intensive radiotherapy and intensive chemo therapy. The spectrum of second malignancies in Hodgkin's patients is broad [4,10,13], acute leukemia having been particularly emphasized [5,II,12,14], The increased incidence of second neoplasms in Hodgkin's patients has been attributed to the cellular immune deficiency associated with the disease as well as the immunosuppressive effects of radiotherapy and chemotherapy.…”

Progressive Systemic Sclerosis Complicated with Primary Cerebral Malignant Lymphoma.

“…Although several reports (3)(4)(5)(6)(7)(8) have been published on PSS complicated with malignant lymphoma,none of them has been concerned with primary cerebral malignant lymphoma. Primary cerebral malignant lymphomais a rare disease, but recently it has been increasingly recognized in patients undergoing immunosuppressive therapy after organ transplantation (9) or in AIDS patients (10).…”

Myeloma in a Case of Hodgkin’s Disease

“…In this regard, Hodgkin's disease is probably no exception and the occurr ence of second malignancies in this disease has now been the subject of a number of reports [1,2,4,6,9,10,[12][13][14], For example, the occurrence of leukaemia in Hodgkin's disease is now well documented [15]. Howev er, myeloma in established Hodgkin's disease seems to be rare, and we have been able to find only one previous report of this association, in which 2 patients with Hodgkin's disease treated with radiotherapy alone, developed typical myelomatosis [7].…”