Hodgkin Lymphoma–related Vanishing Bile Duct Syndrome Cholestasis Resolved After Chemotherapy

González, Rafael Lazcano; Parmar, Pooja; Hardee, Steven; Chang-Halpenny, C.N.; Titapiwatanakun, Ruetima; Tcheng, Wendy Y.; Yeung, Karla Au; Fernández, Karen S.

doi:10.1097/mph.0000000000002223

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…8 9 Since first described in 1993, 37 cases of VBDS associated cHL have been reported in the English medical literature. [10][11][12][13][14][15][16][17][18][19][20] Including our case, of the cases with known outcomes, 16 of 35 resulted in short interval death with the majority appearing to have died of liver related complications. In contrast, since 2019 only 3 of 11 cases ended in death.…”

Section: Discussionmentioning

confidence: 82%

Hodgkin lymphoma associated vanishing bile duct syndrome treated successfully with a brentuximab based regimen

Morgan,

Weishar,

Kwok

et al. 2023

BMJ Case Rep

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We report a combination therapy to successfully treat a patient with Hodgkin’s lymphoma complicated by vanishing bile duct syndrome. Our patient was in his 20s and presented with jaundice, emesis, B symptoms and diffuse lymphadenopathy along with cholestatic liver injury prompting a liver biopsy, which revealed this diagnosis, after the exclusion of other aetiologies. Our treatment regimen incorporated brentuximab along with other more conventional agents which attempted to maximise therapeutic efficacy while minimising the consequences of hepatotoxicity on the treatment protocol. Although this patient’s treatment course was complicated because of neutropenic infections, the patient achieved a complete metabolic response and is now more than 1 year off therapy.

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Section: Discussionmentioning

confidence: 82%

Hodgkin lymphoma associated vanishing bile duct syndrome treated successfully with a brentuximab based regimen

Morgan,

Weishar,

Kwok

et al. 2023

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…Vanishing bile duct syndrome (VBDS) is a group of genetic and acquired disorders that lead to the progressive disappearance and destruction of intrahepatic bile ducts (ductopenia). 1,2 Although the exact pathogenesis of VBDS is poorly understood, recent studies have reported Hodgkin's lymphoma (HL) as one of the probable causes of VBDS. 2,3 Hodgkin's lymphoma is a type of cancer that lymphocytes grow out of control, causing swollen lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Although the exact pathogenesis of VBDS is poorly understood, recent studies have reported Hodgkin's lymphoma (HL) as one of the probable causes of VBDS. 2,3 Hodgkin's lymphoma is a type of cancer that lymphocytes grow out of control, causing swollen lymph nodes. Hodgkin's lymphoma can also be seen in bone marrow transplant patients.…”

Section: Introductionmentioning

confidence: 99%