Hodgkin–Huxley model based on ionic transport in axoplasmic fluid

Bhatia, Suman; Singh, Phool; Sharma, Prabha

doi:10.3233/jin-170029

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Bhatia et al [2], have extended the H-H model to define neuronal excitation in terms of axoplasmic fluid parameters. The parameters taken in the model are density, mass fraction of ions, rate of addition of ions, longitudinal diffusivity and axoplasmic fluid viscosity along with temperature which has already been considered in the H-H model [5].…”

Section: Description Of the Modelmentioning

confidence: 99%

“…Cytoplasm present in the axon of the neuronal cell is termed as axoplasm. Axoplasm comprises 87 percent of water and hence axoplasm has been treated as fluid in [2].…”

Section: Introductionmentioning

confidence: 99%

“…Impact of temperature has been studied on membrane voltage [8] and ionic conductance [13] using the H-H model. The model proposed in [2] for neuronal excitation based on axoplasmic fluid properties has investigated the impact of temperature on action potential propagation velocity and axoplasmic fluid viscosity. Their model incorporates other parameters namely: density, the mass fraction of ions, the rate of addition of ions and temperature dependent longitudinal diffusivity.…”

Section: Introductionmentioning

confidence: 99%

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Analyzing the Impact of Temperature on Axoplasmic Fluid Properties Defining Neuronal Excitation

Bhatia

Sharma

Singh

et al. 2020

Journal of Thermal Engineering

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Axoplasmic fluid properties for neuronal excitation have been investigated with respect to temperature. Density, the mass fraction of ions and rate of addition of ions are the parameters considered for characterizing axoplasmic fluid properties. The behavior of these parameters has been analyzed with respect to the changes in temperature ranging from -5 degree Celsius to 35 degree Celsius. The temperature has been defined using Q10of3 coefficient as done in the Hodgkin-Huxley model. The trend of these parameters at different temperatures has been depicted along the axonal length represented through x-axis of the graphs. The conduction velocities of the above said parameters have also been recorded at different temperatures. The range [−5, 35] degree Celsius has been increased by 20 degrees, 10 degree on the lower side and 10 degree on the upper side of the range [−5, 25] degree Celsius and it is found that temperature dependency using Q10of3 coefficient for said parameters is valid only in the temperature ranging from 5 degree Celsius to 25 degree Celsius as it is for membrane voltage in the Hodgkin-Huxley model. These findings strongly support the obtained results and also suggest obtaining the temperature coefficient value which is applicable for a wider range of temperatures impacting neuronal excitation.

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Section: Description Of the Modelmentioning

confidence: 99%

“…Cytoplasm present in the axon of the neuronal cell is termed as axoplasm. Axoplasm comprises 87 percent of water and hence axoplasm has been treated as fluid in [2].…”

Section: Introductionmentioning

confidence: 99%