Hodgkin and non-Hodgkin lymphoma of the head and neck

Weber, Alfred L.; Rahemtullah, Aliyah; Ferry, Judith A.

doi:10.1016/s1052-5149(03)00039-x

Cited by 156 publications

(66 citation statements)

References 54 publications

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“…In patients with thyroid HL women predominate and constitute about 75-80% of reported patients [4,32], while systemic HL has an equal male to female ratio. In the paper describing the largest series of subjects with thyroid HL by Wang et al, an average age of a patient with HL of the thyroid gland was 42 (with range from 18 to 64) and was lower than for NHL (7th decade) [8].…”

Section: Discussionmentioning

confidence: 99%

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Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

et al. 2013

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Lymphomas account for less than 5% of thyroid malignant lesions. Vast majority of them are B-cell non-Hodgkin lymphomas (NHL), while Hodgkin lymphoma (HL) is extremely rare. Here we present two cases of HL, at baseline manifesting as a thyroid lesion. First patient, 29-year-old pregnant female, initially suspected for metastatic medullary thyroid cancer, was eventually diagnosed with mixed cellularity type of thyroid HL. Second patient, 22-year-old woman with suspicion of advanced thyroid cancer, was in the end diagnosed with an extra-lymphatic classical HL of the thyroid. In both cases, despite repeated fine-needle aspiration biopsy, cytological examination gave inconclusive or misleading results. On histopathological examination, thyroid tumor cells were positive for CD15 and CD30 antigen, which is typical for Reed-Sternberg cells. In the report authors also discuss difficulties in management as well as potential importance of novel methods such as FISH, PCR and other molecular techniques in diagnostics of thyroid lymphomas.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2896947559559648

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Section: Discussionmentioning

confidence: 99%

“…Extra-nodal origin is more common in NHL and may reach 33% [3]. On the other hand, HL mainly arises in lymph nodes of the neck and mediastinum, while only approximately 5% develop in extra-nodal sites, including tonsils, nasopharynx, parotid glands, thyroid, parathyroid or nasal antrum, with or without concomitant nodal involvement [4]. …”

Section: Introductionmentioning

confidence: 99%

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

et al. 2013

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“…Therefore, in patients with unilateral SOM, differential diagnosis of any nasopharyngeal tumor is necessary. If tumor-like lesions are found, prompt pathological examination should be performed because malignant tumors, for example nasopharyngeal carcinoma or malignant lymphoma, can arise in this region 10 . Among 78 cases of tumor and tumorlike lesions in the ET reported over the last 123 years, 1 29 (37%) contained malignancy, including melanoma, 6 carcinoma 8 and sarcoma 11 .…”

Section: Discussionmentioning

confidence: 99%

Osseous Hamartoma Arising from the Eustachian Tube

Kawamoto

Katori

Honkura

et al. 2013

Clinics and Practice

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A fairly quite rare case of osseous tumor arising from the Eustachian tube (ET) is described. A 56-year-old man presented with a smooth bulky mass in the nasopharynx and secretory otitis media in the right ear. Computed tomography and magnetic resonance imaging indicated a solid tumor-like region occupying the nasopharynx with apparent extension to the right ET. Transnasal endoscopic surgery demonstrated that the tumor had originated from the ET, and the tumor was partially removed in the area where it had expanded into the nasopharynx. The pathological diagnosis was an osseous hamartoma consisting of bony tissue, fat cells and fibroblasts. To our knowledge, this is the first reported case of osseous hamartoma arising from the ET in the world literature. The patient presented symptoms of nasal obstruction and unilateral aural fullness. Reduction surgery and tympanostomy tube insertion were useful for accurate diagnosis and resolution of the symptoms.

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“…Deguelin can inhibit the growth of HT-29 cells that derives colonel cancer significantly. It can induce apoptosis of malignant broncho-epithelium cells but cannot kill normal cells [3,4]. It has been discovered that it has chemical therapy activity both in vivo and vitro.…”

Section: Discussionmentioning

confidence: 99%

Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro

Cao

Cui

et al. 2009

Int J Hematol

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To investigate the anti-cancer effects and molecular mechanism of deguelin on the human leukemia HL-60 cells, to explore the expression and clinical significance of p-AKT, survivin and Bcl-2 in leukemia cell line HL-60 cell. Cell growth rate was assessed by MTT assay. Apoptotic index was evaluated by TUNEL staining. Apoptosis was detected by Annexin V-FITC Apoptosis Detection Kit and transmission electron microscopy (TEM), expression of p-Akt, Bcl-2 and surviving in HL-60 cells was checked by Western blot. Deguelin presented striking proliferation inhibition potency on HL-60 cells in vitro, with the I(C50) value for 48 h being 20.14 nM, and induced apoptosis in HL-60 in a concentration-time-dependent manner. Apoptotic bodies and cell shrinkage and fragmentation were observed by TUNEL and TEM. Deguelin-induced cells morphological changes and degraded several kinase proteins, including Bcl-2 and survivin (members of lap). The degradation of these kinases blocked PI3K/Akt survival signal pathways, inducing apoptosis. Deguelin may induce HL-60 cell apoptosis through depletion of multiple kinase proteins and blockage of survival signal pathways of HL-60 cells.

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Hodgkin and non-Hodgkin lymphoma of the head and neck

Cited by 156 publications

References 54 publications

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

Osseous Hamartoma Arising from the Eustachian Tube

Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro

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