HMW-Adiponectin Associates with Triglyceride Concentrations in Type 1 Diabetic Patients

Abstract

Aim:The objective of this study was to investigate the relation between serum high molecular weight (HMW)-adiponectin concentration and fasting and postprandial blood glycemic and lipid parameters in type 1 diabetic patients. Methods: Type 1 diabetic patients treated with short-acting insulin analogs and healthy volunteers were recruited. The subjects were divided into two groups based on the mean HMW-adiponectin value of 12.2 mg/L: low HMW-adiponectin (men/women 7/2) and high HMW-adiponectin (men/ women 3/8). Blood samples were collected after an overnight fast, and 30 − 180 min after consuming white bread (B) or white bread with butter (BB). Results: Type 1 diabetic patients with high HMW-adiponectin had lower triglyceride and remnant like particle (RLP)-triglyceride concentrations than those with low HMW-adiponectin (p 0.01), and had a higher lipoprotein lipase mass (p 0.01) than healthy subjects (men/women 8/6). After B and BB meals, type 1 diabetic patients with high HMW-adiponectin consistently had lower triglyceride and RLP-triglyceride concentrations for up to 180 min than those with low HMW-adiponectin (p 0.01); however, apoB48 did not differ between these two groups. Fasting and postprandial plasma glucose were higher in both diabetic groups than in healthy subjects (p 0.001), with no significant difference between patient groups. Conclusion: HMW-adiponectin is more strongly associated with very low density lipoprotein remnant metabolism than glucose utilization in type 1 diabetic patients receiving short-acting insulin analogs. J Atheroscler

Adiponectin and lipoprotein metabolism

“…This lack of association may be attributed to the small variation in adiponectin concentration in these categories. Triglycerides have also been found to be correlated with serum HMW adiponectin, which is considered the most biologically active fraction of adiponectin (20)(21)(22), and a similar association between adiponectin and VLDL-C has been reported (17,20,56,58). It appears that adiponectin correlates more strongly with the triglyceride content than the obesity reviews Adiponectin and lipoproteins G. A.…”

“…1) Almost all of the studies reported that circulating adiponectin is positively correlated with the serum level of HDL-C (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). HDL-C has also been shown to be positively correlated with high-molecular-weight (HMW) adiponectin, which is considered the most biologically active fraction of adiponectin (5,(20)(21)(22), with quite a high correlation coefficient, and this association was independent of various measures of adiposity and of insulin sensitivity (4,6,7,10,23,24). The results of several studies using transgenic adiponectin-overexpressing mice, adiponectinknockout mice or various cell lines incubated with adiponectin suggest causality in the adiponectin-HDL relationship and indicate that this association is possibly bidirectional.…”

“…With regard to a possible relationship between circulating adiponectin and LDL-C, the majority of studies have shown no association (7,(10)(11)(12)21,24,36,54,58), apart from some that showed a negative relationship between adiponectin levels and LDL-C, but the association was weak and with inconsistency among the various subgroups of the study populations (3,8,13,53). In most of these studies reporting a relationship between adiponectin and LDL-C, the LDL-C was assessed by indirect calculation, using the Friedewald equation [LDL-C = TC − (HDL-C + TRG/5)] (TC: total cholesterol), which is less accurate than direct measurement of LDL-C, especially in subjects with a considerable degree of hypertriglyceridaemia.…”

Fasting remnant lipoproteins can predict postprandial hyperlipidemia

“…Rubin et al demonstrated that postprandial plasma adiponectin values decreased after oral loading with 75 g of glucose or with a high-fat meal (58 g of fat) and that postprandial TG concentrations correlated with fasting adiponectin concentration in a 45- to 65-year-old population including those with metabolic syndrome [16]. Moreover, Maruyama et al found lower TG and RLP-TG concentrations among individuals with type 1 diabetes and a high, rather than a low baseline HMW adiponectin concentration at baseline and at 3 h after test meal loading [17]. The present study demonstrated that fasting adiponectin concentration positively correlated with fasting HDL-C and apoA-I concentrations, and negatively correlated with fasting and postprandial values of TG, RemL-C, RLP-C, RLP-TG, non-HDL-C/HDL-C, LDL-C/HDL-C and TG/apoB.…”

“…Rubin et al demonstrated that postprandial TG concentrations correlate with fasting adiponectin concentrations in 45 - 65-year-old individuals, including those with metabolic syndrome [16]. Maruyama et al reported that serum concentrations of high molecular weight (HMW) adiponectin are associated with those of TG and remnant-like particle-triglyceride (RLP-TG) in individuals with type 1 diabetes before and after test meal loading [17]. …”